Recognition of specific ubiquitin conjugates is important for the proteolytic functions of the ubiquitin-associated domain proteins Dsk2 and Rad23.
about
Rad23 ubiquitin-associated domains (UBA) inhibit 26 S proteasome-catalyzed proteolysis by sequestering lysine 48-linked polyubiquitin chainsUbiquitin-independent proteasomal degradation of endoplasmic reticulum-localized connexin43 mediated by CIP75A complex between peptide:N-glycanase and two proteasome-linked proteins suggests a mechanism for the degradation of misfolded glycoproteinsNEDD8 ultimate buster-1L interacts with the ubiquitin-like protein FAT10 and accelerates its degradationUbiquitin receptor proteins hHR23a and hPLIC2 interactThe UBA domains of NUB1L are required for binding but not for accelerated degradation of the ubiquitin-like modifier FAT10Role of the UBL-UBA protein KPC2 in degradation of p27 at G1 phase of the cell cycle.Histone deacetylase 6 binds polyubiquitin through its zinc finger (PAZ domain) and copurifies with deubiquitinating enzymesInvolvement of the DNA repair protein hHR23 in p53 degradationDiversity of degradation signals in the ubiquitin-proteasome systemThe ubiquitin-associated domain of hPLIC-2 interacts with the proteasomeDimerization of ubiquilin is dependent upon the central region of the protein: evidence that the monomer, but not the dimer, is involved in binding presenilinsA novel regulation mechanism of DNA repair by damage-induced and RAD23-dependent stabilization of xeroderma pigmentosum group C proteinAtaxin-3 interactions with rad23 and valosin-containing protein and its associations with ubiquitin chains and the proteasome are consistent with a role in ubiquitin-mediated proteolysisStructural determinants for the binding of ubiquitin-like domains to the proteasomeA method to identify p62’s UBA domain interacting proteinsThe recognition of ubiquitinated proteins by the proteasomeBinding surface mapping of intra- and interdomain interactions among hHR23B, ubiquitin, and polyubiquitin binding site 2 of S5aAffinity Makes the Difference: Nonselective Interaction of the UBA Domain of Ubiquilin-1 with Monomeric Ubiquitin and Polyubiquitin ChainsStructure of Rpn10 and Its Interactions with Polyubiquitin Chains and the Proteasome Subunit Rpn12Proteasome subunit Rpn1 binds ubiquitin-like protein domains.Multiple interactions of rad23 suggest a mechanism for ubiquitylated substrate delivery important in proteolysisYeast Pth2 is a UBL domain-binding protein that participates in the ubiquitin-proteasome pathway.Analysis of polyubiquitin conjugates reveals that the Rpn10 substrate receptor contributes to the turnover of multiple proteasome targets.Rad23 and Rpn10 serve as alternative ubiquitin receptors for the proteasome.The Rsp5 ubiquitin ligase is coupled to and antagonized by the Ubp2 deubiquitinating enzyme.Rad4 regulates protein turnover at a postubiquitylation step.A genomic screen identifies Dsk2p and Rad23p as essential components of ER-associated degradationCentrin/Cdc31 is a novel regulator of protein degradation.Rpn13p and Rpn14p are involved in the recognition of ubiquitinated Gcn4p by the 26S proteasome.Targeting proteins for degradationProteotoxic stress increases nuclear localization of ataxin-3A genome-wide synthetic dosage lethality screen reveals multiple pathways that require the functioning of ubiquitin-binding proteins Rad23 and Dsk2A novel connexin43-interacting protein, CIP75, which belongs to the UbL-UBA protein family, regulates the turnover of connexin43.Components of the ubiquitin-proteasome pathway compete for surfaces on Rad23 family proteins.Proteasome-mediated degradation of cotranslationally damaged proteins involves translation elongation factor 1A.Rad23 escapes degradation because it lacks a proteasome initiation regionDelivery of ubiquitinated substrates to protein-unfolding machines.Rad23 promotes the targeting of proteolytic substrates to the proteasome.Werner helicase-interacting protein 1 binds polyubiquitin via its zinc finger domain.
P2860
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P2860
Recognition of specific ubiquitin conjugates is important for the proteolytic functions of the ubiquitin-associated domain proteins Dsk2 and Rad23.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh-hant
name
Recognition of specific ubiqui ...... omain proteins Dsk2 and Rad23.
@en
Recognition of specific ubiqui ...... omain proteins Dsk2 and Rad23.
@nl
type
label
Recognition of specific ubiqui ...... omain proteins Dsk2 and Rad23.
@en
Recognition of specific ubiqui ...... omain proteins Dsk2 and Rad23.
@nl
prefLabel
Recognition of specific ubiqui ...... omain proteins Dsk2 and Rad23.
@en
Recognition of specific ubiqui ...... omain proteins Dsk2 and Rad23.
@nl
P2860
P356
P1476
Recognition of specific ubiqui ...... omain proteins Dsk2 and Rad23.
@en
P2093
Ashwani Sastry
P2860
P304
11691-11695
P356
10.1074/JBC.M200245200
P407
P577
2002-01-22T00:00:00Z