Arg(362) and Tyr(365) of the botulinum neurotoxin type a light chain are involved in transition state stabilization.
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Structure- and substrate-based inhibitor design for Clostridium botulinum neurotoxin serotype ASubstrate Binding Mode and Its Implication on Drug Design for Botulinum Neurotoxin AA Potent Peptidomimetic Inhibitor of Botulinum Neurotoxin Serotype A Has a Very Different Conformation than SNAP-25 SubstrateIterative Structure-Based Peptide-Like Inhibitor Design against the Botulinum Neurotoxin Serotype AStructural Framework for Covalent Inhibition of Clostridium botulinum Neurotoxin A by Targeting Cys165Botulinum Neurotoxin Is Shielded by NTNHA in an Interlocked ComplexIdentification of the synaptic vesicle glycoprotein 2 receptor binding site in botulinum neurotoxin ALight chain separated from the rest of the type a botulinum neurotoxin molecule is the most catalytically active form.Structural insight into exosite binding and discovery of novel exosite inhibitors of botulinum neurotoxin serotype A through in silico screening.Tetanus neurotoxin utilizes two sequential membrane interactions for channel formation.The closed structure of presequence protease PreP forms a unique 10,000 Angstroms3 chamber for proteolysis.Presynaptic enzymatic neurotoxins.Association of botulinum neurotoxin serotype A light chain with plasma membrane-bound SNAP-25Isolation and functional characterization of the novel Clostridium botulinum neurotoxin A8 subtype.The zinc-dependent protease activity of the botulinum neurotoxinsCleavage of SNAP25 and its shorter versions by the protease domain of serotype A botulinum neurotoxin.Recombinant holotoxoid vaccine against botulism.Receptor and substrate interactions of clostridial neurotoxins.Electrophysiological Characterization of the Antarease Metalloprotease from Tityus serrulatus Venom.Molecular structures and functional relationships in clostridial neurotoxins.Clostridial neurotoxins: mechanism of SNARE cleavage and outlook on potential substrate specificity reengineering.Assembly and function of the botulinum neurotoxin progenitor complexThe blockade of the neurotransmitter release apparatus by botulinum neurotoxins.In Vivo Toxicity and Immunological Characterization of Detoxified Recombinant Botulinum Neurotoxin Type A.Vaccines against Botulism.Botulinum neurotoxin C mutants reveal different effects of syntaxin or SNAP-25 proteolysis on neuromuscular transmission.Identification and characterization of a novel botulinum neurotoxin.The structure of the tetanus toxin reveals pH-mediated domain dynamics.Insights into the different catalytic activities of Clostridium neurotoxinsThe first non Clostridial botulinum-like toxin cleaves VAMP within the juxtamembrane domain.A mouse model for ricin poisoning and for evaluating protective effects of antiricin antibodies.Design and synthesis of substrate-based inhibitors of botulinum neurotoxin type B metalloprotease.Substrate recognition strategy for botulinum neurotoxin serotype A.Structural characterisation of the catalytic domain of botulinum neurotoxin X - high activity and unique substrate specificity.Mechanism of substrate recognition by botulinum neurotoxin serotype A.Multiple Pocket Recognition of SNAP25 by Botulinum Neurotoxin Serotype E
P2860
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P2860
Arg(362) and Tyr(365) of the botulinum neurotoxin type a light chain are involved in transition state stabilization.
description
2002 nî lūn-bûn
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2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
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2002年學術文章
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2002年學術文章
@zh-hant
name
Arg(362) and Tyr(365) of the b ...... ransition state stabilization.
@en
type
label
Arg(362) and Tyr(365) of the b ...... ransition state stabilization.
@en
prefLabel
Arg(362) and Tyr(365) of the b ...... ransition state stabilization.
@en
P2093
P356
P1433
P1476
Arg(362) and Tyr(365) of the b ...... ransition state stabilization.
@en
P2093
Astrid Kollewe
Jürgen Alves
Steffen Bade
Thomas Binz
P304
P356
10.1021/BI0157969
P407
P577
2002-02-01T00:00:00Z