High resolution, high-throughput amide deuterium exchange-mass spectrometry (DXMS) determination of protein binding site structure and dynamics: utility in pharmaceutical design.
about
Molecular basis for substrate recognition by MTMR2, a myotubularin family phosphoinositide phosphatase.Mass spectrometry-based methods to study protein architecture and dynamicsMolecular Mimicry in Innate Immunity: CRYSTAL STRUCTURE OF A BACTERIAL TIR DOMAINInsights into the molecular activation mechanism of the RhoA-specific guanine nucleotide exchange factor, PDZRhoGEF.A Conserved Glu–Arg Salt Bridge Connects Coevolved Motifs That Define the Eukaryotic Protein Kinase FoldB-Cell Epitopes in GroEL of Francisella tularensisHydrogen exchange mass spectrometry: are we out of the quicksand?Distal loop flexibility of a regulatory domain modulates dynamics and activity of C-terminal SRC kinase (csk)Protein structure change studied by hydrogen-deuterium exchange, functional labeling, and mass spectrometry.Construct optimization for protein NMR structure analysis using amide hydrogen/deuterium exchange mass spectrometry.Controlling hydrogen scrambling in multiply charged protein ions during collisional activation: implications for top-down hydrogen/deuterium exchange MS utilizing collisional activation in the gas phase.The high-throughput protein sample production platform of the Northeast Structural Genomics Consortium.Future directions of structural mass spectrometry using hydroxyl radical footprinting.Preparation of protein samples for NMR structure, function, and small-molecule screening studiesAdvanced mass spectrometry-based methods for the analysis of conformational integrity of biopharmaceutical productsLigand-induced global transitions in the catalytic domain of protein kinase A.The Deuterator: software for the determination of backbone amide deuterium levels from H/D exchange MS data.Quantifying protein interface footprinting by hydroxyl radical oxidation and molecular dynamics simulation: application to galectin-1.Automated data reduction for hydrogen/deuterium exchange experiments, enabled by high-resolution Fourier transform ion cyclotron resonance mass spectrometry.A microscale protein NMR sample screening pipeline.Conformation and dynamics of biopharmaceuticals: transition of mass spectrometry-based tools from academe to industry.Ebola virus glycoprotein needs an additional trigger, beyond proteolytic priming for membrane fusionProbing the conformation of a prion protein fibril with hydrogen exchange.HDX workbench: software for the analysis of H/D exchange MS data.Fourier transform mass spectrometry to monitor hyaluronan-protein interactions: use of hydrogen/deuterium amide exchangeApoE: In Vitro Studies of a Small Molecule Effector.Emerging mass spectrometry-based approaches to probe protein-receptor interactions: focus on overcoming physiological barriersResolving isotopic fine structure to detect and quantify natural abundance- and hydrogen/deuterium exchange-derived isotopomers.The amino terminus of cGMP-dependent protein kinase Iβ increases the dynamics of the protein's cGMP-binding pocketsDifferential hydrogen/deuterium exchange mass spectrometry analysis of protein-ligand interactionsEpitope mapping of a 95 kDa antigen in complex with antibody by solution-phase amide backbone hydrogen/deuterium exchange monitored by Fourier transform ion cyclotron resonance mass spectrometry.Advances and challenges in analytical characterization of biotechnology products: mass spectrometry-based approaches to study properties and behavior of protein therapeuticsRapid refinement of crystallographic protein construct definition employing enhanced hydrogen/deuterium exchange MS.High Resolution Mapping of Bactericidal Monoclonal Antibody Binding Epitopes on Staphylococcus aureus Antigen MntC.Scope and utility of hydrogen exchange as a tool for mapping landscapesStructural basis of specific interactions of Lp-PLA2 with HDL revealed by hydrogen deuterium exchange mass spectrometryOn the use of DXMS to produce more crystallizable proteins: structures of the T. maritima proteins TM0160 and TM1171.Dissecting interdomain communication within cAPK regulatory subunit type IIbeta using enhanced amide hydrogen/deuterium exchange mass spectrometry (DXMS)Apolipoprotein A-I is a selective target for myeloperoxidase-catalyzed oxidation and functional impairment in subjects with cardiovascular disease.Discovery of protective B-cell epitopes for development of antimicrobial vaccines and antibody therapeutics.
P2860
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P2860
High resolution, high-throughput amide deuterium exchange-mass spectrometry (DXMS) determination of protein binding site structure and dynamics: utility in pharmaceutical design.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh-hant
name
High resolution, high-throughp ...... lity in pharmaceutical design.
@en
High resolution, high-throughp ...... lity in pharmaceutical design.
@nl
type
label
High resolution, high-throughp ...... lity in pharmaceutical design.
@en
High resolution, high-throughp ...... lity in pharmaceutical design.
@nl
prefLabel
High resolution, high-throughp ...... lity in pharmaceutical design.
@en
High resolution, high-throughp ...... lity in pharmaceutical design.
@nl
P356
P1476
High resolution, high-throughp ...... ility in pharmaceutical design
@en
P2093
P356
10.1002/JCB.10069
P478
P577
2001-01-01T00:00:00Z