Metabolism and disposition of oral dabrafenib in cancer patients: proposed participation of aryl nitrogen in carbon-carbon bond cleavage via decarboxylation following enzymatic oxidation.

Metabolism and disposition of oral dabrafenib in cancer patients: proposed participation of aryl nitrogen in carbon-carbon bond cleavage via decarboxylation following enzymatic oxidation.

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http://www.wikidata.org/entity/Q43887093
Safe handling of oral antineoplastic medications: focus on targeted therapeutics in the home settingSimple and cost-effective liquid chromatography-mass spectrometry method to measure dabrafenib quantitatively and six metabolites semi-quantitatively in human plasmaImaging MS in Toxicology: An Investigation of Juvenile Rat Nephrotoxicity Associated with Dabrafenib Administration.Dabrafenib in combination with trametinib for the treatment of metastatic melanoma.Carbon-carbon bond cleavage and formation reactions in drug metabolism and the role of metabolic enzymes.Regulatory aspects of human radiolabeled mass balance studies in oncology: concise review.Dabrafenib plus Trametinib: a Review in Advanced Melanoma with a BRAF (V600) Mutation.Pharmacokinetics of dabrafenib in a patient with metastatic melanoma undergoing haemodialysis.Dabrafenib for the treatment of melanoma.Practical Recommendations for Therapeutic Drug Monitoring of Kinase Inhibitors in Oncology.Human absorption, distribution, metabolism and excretion properties of drug molecules: a plethora of approachesEvaluation of the effect of dabrafenib and metabolites on QTc interval in patients with BRAF V600-mutant tumours.Assessment of the drug interaction potential and single- and repeat-dose pharmacokinetics of the BRAF inhibitor dabrafenib.Population pharmacokinetics of dabrafenib, a BRAF inhibitor: effect of dose, time, covariates, and relationship with its metabolites.
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Metabolism and disposition of oral dabrafenib in cancer patients: proposed participation of aryl nitrogen in carbon-carbon bond cleavage via decarboxylation following enzymatic oxidation.

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http://www.wikidata.org/entity/Q43887093
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2013 nî lūn-bûn
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2013年の論文
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2013年学术文章
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name
Metabolism and disposition of ...... following enzymatic oxidation.
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Metabolism and disposition of ...... following enzymatic oxidation.
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Metabolism and disposition of ...... following enzymatic oxidation.
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Metabolism and disposition of ...... following enzymatic oxidation.
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Metabolism and disposition of ...... following enzymatic oxidation.
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Metabolism and disposition of ...... following enzymatic oxidation.
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Metabolism and disposition of ...... following enzymatic oxidation.
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P2093
P304
P31
P356
P433
P478
P50
P577
P5875
P698