The new phosphodiesterase 4 inhibitor roflumilast is efficacious in exercise-induced asthma and leads to suppression of LPS-stimulated TNF-alpha ex vivo.
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Molecular cloning and subcellular distribution of the novel PDE4B4 cAMP-specific phosphodiesterase isoformDeletion of phosphodiesterase 4D in mice shortens alpha(2)-adrenoceptor-mediated anesthesia, a behavioral correlate of emesisPDE4 inhibitors: current statusThe inhaled phosphodiesterase 4 inhibitor GSK256066 reduces allergen challenge responses in asthma.Aging-related hyperinflammation in endotoxemia is mediated by the alpha2A-adrenoceptor and CD14/TLR4 pathways.The effect of the novel phosphodiesterase-4 inhibitor MEM 1414 on the allergen induced responses in mild asthmaChronic obstructive pulmonary disease * 12: New treatments for COPDNew strategies in the treatment and prevention of allergic diseases.Lack of a pharmacokinetic interaction between steady-state roflumilast and single-dose midazolam in healthy subjects.New anti-inflammatory therapies and targets for asthma and chronic obstructive pulmonary disease.PDE4 inhibition suppresses IL-17-associated immunity in dry eye diseaseTaming the neutrophil: calcium clearance and influx mechanisms as novel targets for pharmacological control.Cyclic nucleotide phosphodiesterases as targets for treatment of haematological malignancies.Handle with care: targeting neutrophils in chronic obstructive pulmonary disease and severe asthma?The potential role of roflumilast: the new phosphodiesterase-4 inhibitor.Roflumilast: a phosphodiesterase-4 inhibitor for the treatment of respiratory disease.Population PK-PD Model for Tolerance Evaluation to the p38 MAP Kinase Inhibitor BCT197.Nasal cytotoxic and carcinogenic activities of systemically distributed organic chemicals.Treating COPD with PDE 4 inhibitors.Phosphodiesterase 4 inhibition but not beta-adrenergic stimulation suppresses tumor necrosis factor-alpha release in peripheral blood mononuclear cells in septic shock.Phosphodiesterase 4 inhibitors augment levels of glucocorticoid receptor in B cell chronic lymphocytic leukemia but not in normal circulating hematopoietic cellsTreatment of chronic obstructive pulmonary disease with roflumilast, a new phosphodiesterase 4 inhibitor.Effects of asthma treatment: the present and future.Roflumilast: first phosphodiesterase 4 inhibitor approved for treatment of COPD.Phosphodiesterase-4 inhibitor therapy for lung diseases.Pharmacotherapy of critical asthma syndrome: current and emerging therapies.PDE inhibitors currently in early clinical trials for the treatment of asthma.Roles of roflumilast, a selective phosphodiesterase 4 inhibitor, in airway diseases.Novel anti-inflammatory treatments for asthma.Phosphodiesterase 4 inhibitor GPD-1116 markedly attenuates the development of cigarette smoke-induced emphysema in senescence-accelerated mice P1 strain.Cilomilast, an orally active phosphodiesterase 4 inhibitor for the treatment of COPD.Treatment of obstructive airway diseases with roflumilast, a novel phosphodiesterase 4 inhibitor.Phosphodiesterase 4 inhibitors: antiinflammatory therapy for chronic obstructive pulmonary disease at last?The targeted oral, once-daily phosphodiesterase 4 inhibitor roflumilast and the leukotriene receptor antagonist montelukast do not exhibit significant pharmacokinetic interactions.Phosphodiesterase 4 inhibition with roflumilast: a new approach to pulmonary disease.Roflumilast: an oral, once-daily selective PDE-4 inhibitor for the management of COPD and asthmaPharmacological mechanism of roflumilast in the treatment of asthma-COPD overlap
P2860
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P2860
The new phosphodiesterase 4 inhibitor roflumilast is efficacious in exercise-induced asthma and leads to suppression of LPS-stimulated TNF-alpha ex vivo.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh-hant
name
The new phosphodiesterase 4 in ...... -stimulated TNF-alpha ex vivo.
@en
The new phosphodiesterase 4 in ...... -stimulated TNF-alpha ex vivo.
@nl
type
label
The new phosphodiesterase 4 in ...... -stimulated TNF-alpha ex vivo.
@en
The new phosphodiesterase 4 in ...... -stimulated TNF-alpha ex vivo.
@nl
prefLabel
The new phosphodiesterase 4 in ...... -stimulated TNF-alpha ex vivo.
@en
The new phosphodiesterase 4 in ...... -stimulated TNF-alpha ex vivo.
@nl
P2093
P2860
P1476
The new phosphodiesterase 4 in ...... -stimulated TNF-alpha ex vivo.
@en
P2093
Armin Hatzelmann
Guillaume Birraux
Markus Neuhäuser
Thomas Bethke
Violette Leclerc
Wilhelm Wurst
Wolfgang Timmer
P2860
P304
P356
10.1177/00912700222011328
P577
2002-03-01T00:00:00Z