Genotype effects and epistasis in type 1 diabetes and HLA-DQ trans dimer associations with disease. - Wikidata - awgldk - TriplyDB

Genotype effects and epistasis in type 1 diabetes and HLA-DQ trans dimer associations with disease.

Genotype effects and epistasis in type 1 diabetes and HLA-DQ trans dimer associations with disease.

http://www.wikidata.org/entity/Q43903756

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Screening for coeliac disease in adult patients with type 1 diabetes mellitus: myths, facts and controversy Structural and Functional Studies of trans -Encoded HLA-DQ2.3 (DQA1*03:01/DQB1*02:01) Protein Molecule Widespread non-additive and interaction effects within HLA loci modulate the risk of autoimmune diseases Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families The MHC locus and genetic susceptibility to autoimmune and infectious diseases.The Clinical Course of Patients with Preschool Manifestation of Type 1 Diabetes Is Independent of the HLA DR-DQ Genotype HLA-DQ2 and -DQ8 signatures of gluten T cell epitopes in celiac disease HLA-DRB1-DQB1 haplotypes confer susceptibility and resistance to multiple sclerosis in Sardinia.Conditional meta-analysis stratifying on detailed HLA genotypes identifies a novel type 1 diabetes locus around TCF19 in the MHC Relative predispositional effects of HLA class II DRB1-DQB1 haplotypes and genotypes on type 1 diabetes: a meta-analysis.Co-occurrence of type 1 diabetes mellitus and celiac disease Type I diabetes mellitus: genetic factors and presumptive enteroviral etiology or protection.Trans heterodimer between two non-arthritis-associated HLA alleles can predispose to arthritis in humanized mice Evidence that HLA class I and II associations with type 1 diabetes, autoantibodies to GAD and autoantibodies to IA-2, are distinct.Cell-surface MHC density profiling reveals instability of autoimmunity-associated HLA.Recursive organizer (ROR): an analytic framework for sequence-based association analysis.Human MHC architecture and evolution: implications for disease association studies.Epistasis among HLA-DRB1, HLA-DQA1, and HLA-DQB1 loci determines multiple sclerosis susceptibility Synergy Disequilibrium Plots: graphical visualization of pairwise synergies and redundancies of SNPs with respect to a phenotype.No association of multiple type 2 diabetes loci with type 1 diabetes.DQB1 locus alone explains most of the risk and protection in narcolepsy with cataplexy in Europe.Multiple HLA epitopes contribute to type 1 diabetes susceptibility Structural Characteristics of HLA-DQ that May Impact DM Editing and Susceptibility to Type-1 Diabetes.The beta-cell in type 1 diabetes: What have we learned from proteomic studies?Impact of disease heterogeneity on treatment efficacy of immunotherapy in Type 1 diabetes: different shades of gray.Associations of human leukocyte antigens with autoimmune diseases: challenges in identifying the mechanism.Type 1 diabetes-associated HLA-DQ8 transdimer accommodates a unique peptide repertoire.Gene-gene interaction between tuberculosis candidate genes in a South African population.HLA-DRB1 the notorious gene in the mosaic of autoimmunity.Association between polymorphisms of the swine MHC-DQA gene and diarrhoea in three Chinese native piglets.HLA-DQ allele competition in narcolepsy: a comment on Tafti et al. DQB1 locus alone explains most of the risk and protection in narcolepsy with cataplexy in Europe.Progression to type 1 diabetes and autoantibody positivity in relation to HLA-risk genotypes in children participating in the ABIS study.Dendritic Cells Guide Islet Autoimmunity through a Restricted and Uniquely Processed Peptidome Presented by High-Risk HLA-DR.Human islets and dendritic cells generate post-translationally modified islet autoantigens.HLA dosage effect in narcolepsy with cataplexy.HLA class II susceptibility pattern for type 1 diabetes (T1D) in an Iranian population.HLA Class II molecules on haplotypes associated with type 1 diabetes exhibit similar patterns of binding affinities for coxsackievirus P2C peptides.Does a central MHC gene in linkage disequilibrium with HLA-DRB1*0401 affect susceptibility to type 1 diabetes?High-risk genotypes HLA-DR3-DQ2/DR3-DQ2 and DR3-DQ2/DR4-DQ8 in co-occurrence of type 1 diabetes and celiac disease.

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Genotype effects and epistasis in type 1 diabetes and HLA-DQ trans dimer associations with disease.

http://www.wikidata.org/entity/Q43903756

description

2004 nî lūn-bûn

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年學術文章

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2004年學術文章

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Genotype effects and epistasis ...... mer associations with disease.

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Genotype effects and epistasis ...... mer associations with disease.

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type

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Genotype effects and epistasis ...... mer associations with disease.

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Genotype effects and epistasis ...... mer associations with disease.

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prefLabel

Genotype effects and epistasis ...... mer associations with disease.

@en

Genotype effects and epistasis ...... mer associations with disease.

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Genes and Immunity

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Genotype effects and epistasis ...... mer associations with disease.

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P2860

The HLA-DQ2 gene dose effect in celiac disease is directly related to the magnitude and breadth of gluten-specific T cell responses

A correlation between the relative predisposition of MHC class II alleles to type 1 diabetes and the structure of their proteins.

A unified stepwise regression procedure for evaluating the relative effects of polymorphisms within a gene using case/control or family data: application to HLA in type 1 diabetes

Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups

Adaptation of the extended transmission/disequilibrium test to distinguish disease associations of multiple loci: the Conditional Extended Transmission/Disequilibrium Test.

HLA-encoded genetic predisposition in IDDM: DR4 subtypes may be associated with different degrees of protection.

A diabetes-susceptible HLA haplotype is best defined by a combination of HLA-DR and -DQ alleles

MHC-peptide ligand interactions establish a functional threshold for antigen-specific T cell recognition.

Impaired binding of a DQ2 and DQ8-binding HSV VP16 peptide to a DQA1*0501/DQB1*0302 trans class II heterodimer.

Susceptibility to type I diabetes: HLA-DQ and DR revisited.

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type-1 diabetes