Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular g-quadruplex.
about
Vertebrate telomere repeat DNAs favor external loop propeller quadruplex structures in the presence of high concentrations of potassium.Identification of mixed di-cation forms of G-quadruplex in solutionPreferential binding of a G-quadruplex ligand to human chromosome ends.Facilitation of a structural transition in the polypurine/polypyrimidine tract within the proximal promoter region of the human VEGF gene by the presence of potassium and G-quadruplex-interactive agents.Telomere and Telomerase Therapeutics in CancerTherapeutic targeting of replicative immortalityTelomerase as a Cancer Target. Development of New MoleculesG-quadruplexes in pathogens: a common route to virulence control?Distance measurements between paramagnetic ligands bound to parallel stranded guanine quadruplexesTelomestatin-induced telomere uncapping is modulated by POT1 through G-overhang extension in HT1080 human tumor cells.Quadruplex ligands may act as molecular chaperones for tetramolecular quadruplex formationTargeting human telomerase for cancer therapeutics.The G-quadruplex ligand telomestatin impairs binding of topoisomerase IIIalpha to G-quadruplex-forming oligonucleotides and uncaps telomeres in ALT cellsIn vitro footprinting of promoter regions within supercoiled plasmid DNA.Mechanistic insight into ligand binding to G-quadruplex DNAChemistry in human telomere biology: structure, function and targeting of telomere DNA/RNA.Macrocyclic pyridyl polyoxazoles: selective RNA and DNA G-quadruplex ligands as antitumor agents.Identification of novel quadruplex ligands from small molecule libraries by FRET-based high-throughput screening.Structural insights into G-quadruplexes: towards new anticancer drugs.Cyclo[n]pyrroles: size and site-specific binding to G-quadruplexes.Stabilization of a G-Quadruplex from Unfolding by Replication Protein A Using Potassium and the Porphyrin TMPyP4Formation of pseudosymmetrical G-quadruplex and i-motif structures in the proximal promoter region of the RET oncogene.The proximal promoter region of the human vascular endothelial growth factor gene has a G-quadruplex structure that can be targeted by G-quadruplex-interactive agents.Cation involvement in telomestatin binding to g-quadruplex DNA.Synthesis of Macrocyclic Hexaoxazole (6OTD) Dimers, Containing Guanidine and Amine Functionalized Side Chains, and an Evaluation of Their Telomeric G4 Stabilizing Properties.A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands."One ring to bind them all"-part I: the efficiency of the macrocyclic scaffold for g-quadruplex DNA recognition.RTEL1: an essential helicase for telomere maintenance and the regulation of homologous recombination.Interaction of pyrrolobenzodiazepine (PBD) ligands with parallel intermolecular G-quadruplex complex using spectroscopy and ESI-MS.The guanine-quadruplex structure in the human c-myc gene's promoter is converted into B-DNA form by the human poly(ADP-ribose)polymerase-1.A small molecule inhibitor of Pot1 binding to telomeric DNA.Telomere maintenance as a target for anticancer drug discovery.Formation of a unique cluster of G-quadruplex structures in the HIV-1 Nef coding region: implications for antiviral activity.G-quadruplexes: from guanine gels to chemotherapeuticsA Personal History of Quadruplex-Small Molecule Targeting.Defining the mode, energetics and specificity with which a macrocyclic hexaoxazole binds to human telomeric G-quadruplex DNAHit Identification of a Novel Dual Binder for h-telo/c-myc G-Quadruplex by a Combination of Pharmacophore Structure-Based Virtual Screening and Docking Refinement.Reevaluation of telomerase inhibition by quadruplex ligands and their mechanisms of actionTelomerase: a potential therapeutic target for cancer.Telomerase and its potential for therapeutic intervention.
P2860
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P2860
Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular g-quadruplex.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh-hant
name
Telomestatin, a potent telomer ...... c intramolecular g-quadruplex.
@en
Telomestatin, a potent telomer ...... c intramolecular g-quadruplex.
@nl
type
label
Telomestatin, a potent telomer ...... c intramolecular g-quadruplex.
@en
Telomestatin, a potent telomer ...... c intramolecular g-quadruplex.
@nl
prefLabel
Telomestatin, a potent telomer ...... c intramolecular g-quadruplex.
@en
Telomestatin, a potent telomer ...... c intramolecular g-quadruplex.
@nl
P2093
P356
P1476
Telomestatin, a potent telomer ...... c intramolecular g-quadruplex.
@en
P2093
Hariprasad Vankayalapati
Kazuo Shin-Ya
Konstanty Wierzba
Laurence H Hurley
Mu-Yong Kim
P304
P356
10.1021/JA017308Q
P407
P577
2002-03-01T00:00:00Z