Herpes simplex virus helicase-primase inhibitors are active in animal models of human disease.
about
The Epstein-Barr virus replication protein BBLF2/3 provides an origin-tethering function through interaction with the zinc finger DNA binding protein ZBRK1 and the KAP-1 corepressorMechanism and evolution of DNA primasesThe DNA helicase-primase complex as a target for herpes viral infectionCurrent and potential treatments for ubiquitous but neglected herpesvirus infectionsRole of RNA helicases in HIV-1 replicationRing Expanded Nucleoside Analogues Inhibit RNA Helicase and Intracellular Human Immunodeficiency Virus Type 1 ReplicationNovel agents and strategies to treat herpes simplex virus infections.Agents and strategies in development for improved management of herpes simplex virus infection and disease.Helicase-primase inhibitors for herpes simplex virus: looking to the future of non-nucleoside inhibitors for treating herpes virus infections.The ATPases: a new family for a family-based drug design approach.Emerging drugs for varicella-zoster virus infections.A cutting-edge view on the current state of antiviral drug development.Unique helicase determinants in the essential conjugative TraI factor from Salmonella enterica serovar Typhimurium plasmid pCU1.Resistance of herpes simplex viruses to nucleoside analogues: mechanisms, prevalence, and managementSevere acute respiratory syndrome coronavirus replication inhibitor that interferes with the nucleic acid unwinding of the viral helicaseIdentification and analysis of hepatitis C virus NS3 helicase inhibitors using nucleic acid binding assaysNoninvasive bioluminescence imaging of herpes simplex virus type 1 infection and therapy in living mice.Cooperative translocation enhances the unwinding of duplex DNA by SARS coronavirus helicase nsP13.Amino acid changes within conserved region III of the herpes simplex virus and human cytomegalovirus DNA polymerases confer resistance to 4-oxo-dihydroquinolines, a novel class of herpesvirus antiviral agentsMechanisms of helicases.The hepatitis C virus NS3 protein: a model RNA helicase and potential drug targetOral bioavailability and in vivo efficacy of the helicase-primase inhibitor BILS 45 BS against acyclovir-resistant herpes simplex virus type 1.Helicases as antiviral drug targets.Discovering new medicines targeting helicases: challenges and recent progress.Benzothiazole and Pyrrolone Flavivirus Inhibitors Targeting the Viral Helicase.Development of new antivirals for herpesviruses.Helicase primase: targeting the Achilles heel of herpes simplex viruses.Antivirals and antiviral strategies.Resistance of herpes simplex virus infections to nucleoside analogues in HIV-infected patients.A mutation in the human herpes simplex virus type 1 UL52 zinc finger motif results in defective primase activity but can recruit viral polymerase and support viral replication efficiently.Emerging therapies for herpes viral infections (types 1 - 8).Update on new antivirals under development for the treatment of double-stranded DNA virus infectionsMain adult herpes virus infections of the CNS.Targeting human papillomavirus genome replication for antiviral drug discoveryUnderstanding helicases as a means of virus control.Identification and analysis of inhibitors targeting the hepatitis C virus NS3 helicasePharmacokinetics and pharmacodynamics of ASP2151, a helicase-primase inhibitor, in a murine model of herpes simplex virus infection.Advances in the antiviral therapy of herpes virus infection in children.Emodin is a novel alkaline nuclease inhibitor that suppresses herpes simplex virus type 1 yields in cell cultures.Interaction of herpes primase with the sugar of a NTP.
P2860
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P2860
Herpes simplex virus helicase-primase inhibitors are active in animal models of human disease.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh
2002年學術文章
@zh-hant
name
Herpes simplex virus helicase- ...... nimal models of human disease.
@en
Herpes simplex virus helicase- ...... nimal models of human disease.
@nl
type
label
Herpes simplex virus helicase- ...... nimal models of human disease.
@en
Herpes simplex virus helicase- ...... nimal models of human disease.
@nl
prefLabel
Herpes simplex virus helicase- ...... nimal models of human disease.
@en
Herpes simplex virus helicase- ...... nimal models of human disease.
@nl
P2093
P2860
P356
P1433
P1476
Herpes simplex virus helicase- ...... nimal models of human disease.
@en
P2093
Anne-Marie Faucher
Bruno Simoneau
Christine A Grygon
Gordon Bolger
James J Crute
Karl D Hargrave
Michael G Cordingley
Michel Liuzzi
Philip Kibler
P2860
P2888
P304
P356
10.1038/NM0402-386
P407
P577
2002-04-01T00:00:00Z