Herpes simplex virus helicase-primase inhibitors are active in animal models of human disease. - Wikidata - awgldk - TriplyDB

Herpes simplex virus helicase-primase inhibitors are active in animal models of human disease.

Herpes simplex virus helicase-primase inhibitors are active in animal models of human disease.

http://www.wikidata.org/entity/Q43943693

about

The Epstein-Barr virus replication protein BBLF2/3 provides an origin-tethering function through interaction with the zinc finger DNA binding protein ZBRK1 and the KAP-1 corepressor Mechanism and evolution of DNA primases The DNA helicase-primase complex as a target for herpes viral infection Current and potential treatments for ubiquitous but neglected herpesvirus infections Role of RNA helicases in HIV-1 replication Ring Expanded Nucleoside Analogues Inhibit RNA Helicase and Intracellular Human Immunodeficiency Virus Type 1 Replication Novel agents and strategies to treat herpes simplex virus infections.Agents and strategies in development for improved management of herpes simplex virus infection and disease.Helicase-primase inhibitors for herpes simplex virus: looking to the future of non-nucleoside inhibitors for treating herpes virus infections.The ATPases: a new family for a family-based drug design approach.Emerging drugs for varicella-zoster virus infections.A cutting-edge view on the current state of antiviral drug development.Unique helicase determinants in the essential conjugative TraI factor from Salmonella enterica serovar Typhimurium plasmid pCU1.Resistance of herpes simplex viruses to nucleoside analogues: mechanisms, prevalence, and management Severe acute respiratory syndrome coronavirus replication inhibitor that interferes with the nucleic acid unwinding of the viral helicase Identification and analysis of hepatitis C virus NS3 helicase inhibitors using nucleic acid binding assays Noninvasive bioluminescence imaging of herpes simplex virus type 1 infection and therapy in living mice.Cooperative translocation enhances the unwinding of duplex DNA by SARS coronavirus helicase nsP13.Amino acid changes within conserved region III of the herpes simplex virus and human cytomegalovirus DNA polymerases confer resistance to 4-oxo-dihydroquinolines, a novel class of herpesvirus antiviral agents Mechanisms of helicases.The hepatitis C virus NS3 protein: a model RNA helicase and potential drug target Oral bioavailability and in vivo efficacy of the helicase-primase inhibitor BILS 45 BS against acyclovir-resistant herpes simplex virus type 1.Helicases as antiviral drug targets.Discovering new medicines targeting helicases: challenges and recent progress.Benzothiazole and Pyrrolone Flavivirus Inhibitors Targeting the Viral Helicase.Development of new antivirals for herpesviruses.Helicase primase: targeting the Achilles heel of herpes simplex viruses.Antivirals and antiviral strategies.Resistance of herpes simplex virus infections to nucleoside analogues in HIV-infected patients.A mutation in the human herpes simplex virus type 1 UL52 zinc finger motif results in defective primase activity but can recruit viral polymerase and support viral replication efficiently.Emerging therapies for herpes viral infections (types 1 - 8).Update on new antivirals under development for the treatment of double-stranded DNA virus infections Main adult herpes virus infections of the CNS.Targeting human papillomavirus genome replication for antiviral drug discovery Understanding helicases as a means of virus control.Identification and analysis of inhibitors targeting the hepatitis C virus NS3 helicase Pharmacokinetics and pharmacodynamics of ASP2151, a helicase-primase inhibitor, in a murine model of herpes simplex virus infection.Advances in the antiviral therapy of herpes virus infection in children.Emodin is a novel alkaline nuclease inhibitor that suppresses herpes simplex virus type 1 yields in cell cultures.Interaction of herpes primase with the sugar of a NTP.

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P2860

Herpes simplex virus helicase-primase inhibitors are active in animal models of human disease.

http://www.wikidata.org/entity/Q43943693

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Nature Medicine

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Anne-Marie Faucher

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Bruno Simoneau

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Christine A Grygon

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Gordon Bolger

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James J Crute

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Karl D Hargrave

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Michael G Cordingley

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Michel Liuzzi

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Philip Kibler

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P2860

Differential effects of famciclovir and valaciclovir on the pathogenesis of herpes simplex virus in a murine infection model including reactivation from latency

An improved assay for nanomole amounts of inorganic phosphate

Replication of herpes simplex virus DNA.

Valaciclovir. A review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy in herpesvirus infections.

Resistance of herpesviruses to antiviral drugs

A DNA helicase induced by herpes simplex virus type 1

Sequence-dependent primer synthesis by the herpes simplex virus helicase-primase complex.

Frequency of acyclovir-resistant herpes simplex virus in clinical specimens and laboratory isolates.

Antiviral resistance in clinical practice.

The structure and function of the HSV DNA replication proteins: defining novel antiviral targets.

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10.1038/NM0402-386

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11927945

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