Gene therapy for prostate cancer delivered by ovine adenovirus and mediated by purine nucleoside phosphorylase and fludarabine in mouse models.
about
Circumventing antivector immunity: potential use of nonhuman adenoviral vectorsStructure of a mutant human purine nucleoside phosphorylase with the prodrug, 2-fluoro-2′-deoxyadenosine and the cytotoxic drug, 2-fluoroadenineProgress and problems with the use of suicide genes for targeted cancer therapyPurine Nucleoside Phosphorylase mediated molecular chemotherapy and conventional chemotherapy: a tangible union against chemoresistant cancerEnhanced efficiency of prodrug activation therapy by tumor-selective replicating retrovirus vectors armed with the Escherichia coli purine nucleoside phosphorylase gene.Targeted enzyme prodrug therapy for metastatic prostate cancer - a comparative study of L-methioninase, purine nucleoside phosphorylase, and cytosine deaminaseOvine atadenovirus: a review of its biology, biosafety profile and application as a gene delivery vector.Development of nonhuman adenoviruses as vaccine vectors.Genetically engineered murine models of prostate cancer: insights into mechanisms of tumorigenesis and potential utility.Novel gene-directed enzyme prodrug therapies against prostate cancer.Therapeutic potential of stem cells expressing suicide genes that selectively target human breast cancer cells: evidence that they exert tumoricidal effects via tumor tropism (review).Construction, rescue, and characterization of vectors derived from ovine atadenovirus.Humanized ADEPT comprised of an engineered human purine nucleoside phosphorylase and a tumor targeting peptide for treatment of cancerDevelopment of gene therapy in association with clinically used cytotoxic deoxynucleoside analogues.PRE-CLINICAL AND CLINICAL VALIDATION OF AN ANTI-CANCER MODALITY THAT ABLATES REFRACTORY, LOW GROWTH FRACTION TUMORS.Targeted expression of Escherichia coli purine nucleoside phosphorylase and Fludara® for prostate cancer therapy.Chick embryo lethal orphan virus can be polymer-coated and retargeted to infect mammalian cells.Gene transfer to mouse testes by electroporation and its influence on spermatogenesis.Preclinical evaluation of a prostate-targeted gene-directed enzyme prodrug therapy delivered by ovine atadenovirus.Prostate cancer transfection by acoustic energy using pEGFP-N1 as reporter gene in the solid Dunning R-3327-MatLu tumor.Efficient Fludarabine-Activating PNP From Archaea as a Guidance for Redesign the Active Site of E. Coli PNP.Delivery of replication-competent retrovirus expressing Escherichia coli purine nucleoside phosphorylase increases the metabolism of the prodrug, fludarabine phosphate and suppresses the growth of bladder tumor xenografts.
P2860
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P2860
Gene therapy for prostate cancer delivered by ovine adenovirus and mediated by purine nucleoside phosphorylase and fludarabine in mouse models.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
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2002年學術文章
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2002年學術文章
@zh-hant
name
Gene therapy for prostate canc ...... d fludarabine in mouse models.
@en
Gene therapy for prostate canc ...... d fludarabine in mouse models.
@nl
type
label
Gene therapy for prostate canc ...... d fludarabine in mouse models.
@en
Gene therapy for prostate canc ...... d fludarabine in mouse models.
@nl
prefLabel
Gene therapy for prostate canc ...... d fludarabine in mouse models.
@en
Gene therapy for prostate canc ...... d fludarabine in mouse models.
@nl
P2093
P2860
P356
P1433
P1476
Gene therapy for prostate canc ...... d fludarabine in mouse models.
@en
P2093
E Bennetts
R Martiniello-Wilks
P2860
P2888
P304
P356
10.1038/SJ.GT.3301698
P577
2002-06-01T00:00:00Z
P5875
P6179
1048174066