about
Polyamine homoeostasis as a drug target in pathogenic protozoa: peculiarities and possibilitiesComparative properties of a three-dimensional model of Plasmodium falciparum ornithine decarboxylase.Savignygrin, a platelet aggregation inhibitor from the soft tick Ornithodoros savignyi, presents the RGD integrin recognition motif on the Kunitz-BPTI fold.Integration and mining of malaria molecular, functional and pharmacological data: how far are we from a chemogenomic knowledge space?Neuropathogenic properties of Argas (Persicargas) walkerae larval homogenates.MADIBA: a web server toolkit for biological interpretation of Plasmodium and plant gene clustersPlasmodium falciparum spermidine synthase inhibition results in unique perturbation-specific effects observed on transcript, protein and metabolite levels.Pathogenic mechanisms of sand tampan toxicoses induced by the tick, Ornithodoros savignyi.A novel inhibitor of Plasmodium falciparum spermidine synthase: a twist in the tailDeletion mutagenesis of large areas in Plasmodium falciparum genes: a comparative study.Heterologous expression of plasmodial proteins for structural studies and functional annotation.Anthracene-polyamine conjugates inhibit in vitro proliferation of intraerythrocytic Plasmodium falciparum parasitesCo-inhibition of Plasmodium falciparum S-adenosylmethionine decarboxylase/ornithine decarboxylase reveals perturbation-specific compensatory mechanisms by transcriptome, proteome, and metabolome analyses.Novel S-adenosyl-L-methionine decarboxylase inhibitors as potent antiproliferative agents against intraerythrocytic Plasmodium falciparum parasites.Functional consequences of perturbing polyamine metabolism in the malaria parasite, Plasmodium falciparum.Resisting resistance: is there a solution for malaria?Exploring inhibition of Pdx1, a component of the PLP synthase complex of the human malaria parasite Plasmodium falciparum.In vitro antiplasmodial activity and cytotoxicity of ethnobotanically selected South African plants.Proteomic profiling of Plasmodium falciparum through improved, semiquantitative two-dimensional gel electrophoresis.Mutational analysis of the hexose transporter of Plasmodium falciparum and development of a three-dimensional model.Amino acid sequence and structure modeling of savignin, a thrombin inhibitor from the tick, Ornithodoros savignyi.Polyamine uptake by the intraerythrocytic malaria parasite, Plasmodium falciparum.In vitro inhibition of Plasmodium falciparum early and late stage gametocyte viability by extracts from eight traditionally used South African plant species.Biochemical characterisation and novel classification of monofunctional S-adenosylmethionine decarboxylase of Plasmodium falciparum.The major tick salivary gland proteins and toxins from the soft tick, Ornithodoros savignyi, are part of the tick Lipocalin family: implications for the origins of tick toxicoses.Plasmodium falciparum: a comparison of synchronisation methods for in vitro cultures.Kinetics of erythrocyte lysis by snake venom cardiotoxins.Cloning, nucleotide sequence and expression of the gene encoding factor Xa inhibitor from the salivary glands of the tick, Ornithodoros savignyi.Structural and mechanistic insights into the action of Plasmodium falciparum spermidine synthase.Novel properties of malarial S-adenosylmethionine decarboxylase as revealed by structural modelling.Detection and micro-scale isolation of a low molecular mass paralysis toxin from the tick, Argas (Persicargas) walkerae.Disaggregation of aggregated platelets by apyrase from the tick, Ornithodoros savignyi (Acari: Argasidae).Similar mechanisms regulate protein exocytosis from the salivary glands of ixodid and argasid ticks.A reassessment of argasid tick salivary gland ultrastructure from an immuno-cytochemical perspective.Transcriptional responses of Plasmodium falciparum to alpha-difluoromethylornithine-induced polyamine depletion.The synergism of cardiotoxin and phospholipase A2 in hemolysis.The influence of tick behavior, biotope and host specificity on concerted evolution of the platelet aggregation inhibitor savignygrin, from the soft tick Ornithodoros savignyi.Structure-based inhibitor screening: a family of sulfonated dye inhibitors for malaria parasite triosephosphate isomerase.The binding of snake venom cardiotoxins to heart cell membranes.Disaggregation of aggregated platelets by savignygrin, a alphaIIbeta3 antagonist from Ornithodoros savignyi.
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description
hulumtues
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հետազոտող
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Abraham I. Louw
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Abraham I. Louw
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Abraham I. Louw
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Abraham I. Louw
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Abraham I. Louw
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Abraham I. Louw
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Abraham I. Louw
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Abraham I. Louw
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Abraham I. Louw
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Abraham I. Louw
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Abraham I. Louw
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Abraham I. Louw
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P106
P1153
7005051103
P21
P31
P496
0000-0002-8036-1513