Differential activation of individual subunits in heteromeric kainate receptors.
about
Functional insights from glutamate receptor ion channel structuresFull Domain Closure of the Ligand-binding Core of the Ionotropic Glutamate Receptor iGluR5 Induced by the High Affinity Agonist Dysiherbaine and the Functional Antagonist 8,9-DideoxyneodysiherbaineGlutamate receptor ion channels: structure, regulation, and functionA gain-of-function mutation in the GRIK2 gene causes neurodevelopmental deficitsAssembly stoichiometry of the GluK2/GluK5 kainate receptor complex.Novel analogs and stereoisomers of the marine toxin neodysiherbaine with specificity for kainate receptorsPharmacological activity of C10-substituted analogs of the high-affinity kainate receptor agonist dysiherbaine.Tethered ligands reveal glutamate receptor desensitization depends on subunit occupancy.Structure of the kainate receptor subunit GluR6 agonist-binding domain complexed with domoic acidThe neurotoxin domoate causes long-lasting inhibition of the kainate receptor GluK5 subunitLigands for ionotropic glutamate receptorsChannel-opening kinetic mechanism of wild-type GluK1 kainate receptors and a C-terminal mutant.Contributions of different kainate receptor subunits to the properties of recombinant homomeric and heteromeric receptors.Channel-opening kinetic mechanism for human wild-type GluK2 and the M867I mutant kainate receptor.Distinct functions of kainate receptors in the brain are determined by the auxiliary subunit Neto1.Synthesis of the dysiherbaine tetrahydropyran core utilizing improved tethered aminohydroxylation conditions.Distinct functional roles of subunits within the heteromeric kainate receptor.Synthesis of the dysiherbaine tetrahydropyran core employing a tethered aminohydroxylation reaction.Recent progress in neuroactive marine natural products.From toxins targeting ligand gated ion channels to therapeutic molecules.Crosslinking the ligand-binding domain dimer interface locks kainate receptors out of the main open state.Concanavalin-A reports agonist-induced conformational changes in the intact GluR6 kainate receptor.Identification of critical functional determinants of kainate receptor modulation by auxiliary protein Neto2.Improved synthesis and in vitro/in vivo activities of natural product-inspired, artificial glutamate analogs.Expression of GluK1c underlies the developmental switch in presynaptic kainate receptor function.Subunit-specific desensitization of heteromeric kainate receptors.Modulation of homomeric and heteromeric kainate receptors by the auxiliary subunit Neto1.
P2860
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P2860
Differential activation of individual subunits in heteromeric kainate receptors.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh
2002年學術文章
@zh-hant
name
Differential activation of individual subunits in heteromeric kainate receptors.
@en
Differential activation of individual subunits in heteromeric kainate receptors.
@nl
type
label
Differential activation of individual subunits in heteromeric kainate receptors.
@en
Differential activation of individual subunits in heteromeric kainate receptors.
@nl
prefLabel
Differential activation of individual subunits in heteromeric kainate receptors.
@en
Differential activation of individual subunits in heteromeric kainate receptors.
@nl
P2093
P1433
P1476
Differential activation of individual subunits in heteromeric kainate receptors.
@en
P2093
Geoffrey T Swanson
Hisao Kamiya
Ryuichi Sakai
Stephen F Heinemann
Wesley Che
P304
P356
10.1016/S0896-6273(02)00676-1
P407
P577
2002-05-01T00:00:00Z