The EBNA-3 gene family proteins disrupt the G2/M checkpoint.
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Role of EBNA-3 Family Proteins in EBV Associated B-cell LymphomagenesisCyclin A/cdk2 coordinates centrosomal and nuclear mitotic eventsKaposi sarcoma herpes virus latency associated nuclear antigen protein release the G2/M cell cycle blocks by modulating ATM/ATR mediated checkpoint pathwayEpstein-Barr virus nuclear antigen 2 (EBNA2) gene deletion is consistently linked with EBNA3A, -3B, and -3C expression in Burkitt's lymphoma cells and with increased resistance to apoptosis.Upregulation of the cell-cycle regulator RGC-32 in Epstein-Barr virus-immortalized cells.Epstein-Barr virus Latent Membrane Protein LMP1 reduces p53 protein levels independent of the PI3K-Akt pathway.Epstein-Barr virus nuclear antigen 3A promotes cellular proliferation by repression of the cyclin-dependent kinase inhibitor p21WAF1/CIP1.Modulation of enhancer looping and differential gene targeting by Epstein-Barr virus transcription factors directs cellular reprogramming.The ATM/ATR signaling effector Chk2 is targeted by Epstein-Barr virus nuclear antigen 3C to release the G2/M cell cycle blockViral manipulation of DNA repair and cell cycle checkpointsNucleoside diphosphate kinase/Nm23 and Epstein-Barr virus.How does Epstein-Barr virus (EBV) complement the activation of Myc in the pathogenesis of Burkitt's lymphoma?Histone deacetylase inhibitors in the generation of the anti-tumour immune response.Deregulation of the cell cycle machinery by Epstein-Barr virus nuclear antigen 3C.Epstein-Barr virus EBNA-3C is targeted to and regulates expression from the bidirectional LMP-1/2B promoter.Downregulation of integrin receptor-signaling genes by Epstein-Barr virus EBNA 3C via promoter-proximal and -distal binding elementsEpstein-barr virus-induced resistance to drugs that activate the mitotic spindle assembly checkpoint in Burkitt's lymphoma cells.Inhibition of S/G2 phase CDK4 reduces mitotic fidelity.Epstein-Barr virus selectively deregulates DNA damage responses in normal B cells but has no detectable effect on regulation of the tumor suppressor p53.Epstein-Barr virus lytic replication elicits ATM checkpoint signal transduction while providing an S-phase-like cellular environment.Defective cell cycle checkpoints as targets for anti-cancer therapies.Gene variations of Epstein-Barr virus nuclear antigen 3A in nasopharyngeal carcinomas, gastric carcinomas and healthy carriers in northern China.Therapeutic Strategies against Epstein-Barr Virus-Associated Cancers Using Proteasome Inhibitors.Pumilio directs deadenylation-associated translational repression of the cyclin-dependent kinase 1 activator RGC-32.Counteracting survival functions of EBNA3C in Epstein-Barr virus (EBV)-driven lymphoproliferative diseases by combination of SAHA and bortezomib.
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P2860
The EBNA-3 gene family proteins disrupt the G2/M checkpoint.
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2004 nî lūn-bûn
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2004年の論文
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2004年学术文章
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2004年学术文章
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The EBNA-3 gene family proteins disrupt the G2/M checkpoint.
@en
The EBNA-3 gene family proteins disrupt the G2/M checkpoint.
@nl
type
label
The EBNA-3 gene family proteins disrupt the G2/M checkpoint.
@en
The EBNA-3 gene family proteins disrupt the G2/M checkpoint.
@nl
prefLabel
The EBNA-3 gene family proteins disrupt the G2/M checkpoint.
@en
The EBNA-3 gene family proteins disrupt the G2/M checkpoint.
@nl
P2093
P2860
P356
P1433
P1476
The EBNA-3 gene family proteins disrupt the G2/M checkpoint.
@en
P2093
Brian Gabrielli
James Flanagan
Kenia G Krauer
Marion Buck
Tom B Sculley
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P2888
P304
P356
10.1038/SJ.ONC.1207253
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P577
2004-02-01T00:00:00Z