Overexpression of activation-induced cytidine deaminase in B cells is associated with production of highly pathogenic autoantibodies.
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Regulation of Aicda expression and AID activityImmunology of neuromyelitis optica during pregnancyAltered pattern of immunoglobulin hypermutation in mice deficient in Slip-GC proteinCD27(-) B-cells produce class switched and somatically hyper-mutated antibodies during chronic HIV-1 infectionMarginal zone precursor B cells as cellular agents for type I IFN-promoted antigen transport in autoimmunity.IL-17 activates the canonical NF-kappaB signaling pathway in autoimmune B cells of BXD2 mice to upregulate the expression of regulators of G-protein signaling 16.Lupus-prone MRL/faslpr/lpr mice display increased AID expression and extensive DNA lesions, comprising deletions and insertions, in the immunoglobulin locus: concurrent upregulation of somatic hypermutation and class switch DNA recombination.Regulation of autoimmune germinal center reactions in lupus-prone BXD2 mice by follicular helper T cellsTetramers reveal IL-17-secreting CD4+ T cells that are specific for U1-70 in lupus and mixed connective tissue disease.T cell subsets and their signature cytokines in autoimmune and inflammatory diseases.General Approach for Tetramer-Based Identification of Autoantigen-Reactive B Cells: Characterization of La- and snRNP-Reactive B Cells in Autoimmune BXD2 MiceCytokine regulation of B-cell migratory behavior favors formation of germinal centers in autoimmune disease.Type I interferon-dependent CD86(high) marginal zone precursor B cells are potent T cell costimulators in miceHSP90 inhibitors decrease AID levels and activity in mice and in human cells.Abatacept decreases disease activity in a absence of CD4(+) T cells in a collagen-induced arthritis model.Interferon-induced mechanosensing defects impede apoptotic cell clearance in lupus.Inhibition of the catalytic function of activation-induced cytidine deaminase promotes apoptosis of germinal center B cells in BXD2 mice.Critical role of activation induced cytidine deaminase in experimental autoimmune encephalomyelitis.Increased expression of activation-induced cytidine deaminase is associated with anti-CCP and rheumatoid factor in rheumatoid arthritis.Estrogen directly activates AID transcription and functionWomen, autoimmunity, and cancer: a dangerous liaison between estrogen and activation-induced deaminase?AID dysregulation in lupus-prone MRL/Fas(lpr/lpr) mice increases class switch DNA recombination and promotes interchromosomal c-Myc/IgH loci translocations: modulation by HoxC4BALB/c mice genetically susceptible to proteoglycan-induced arthritis and spondylitis show colony-dependent differences in disease penetrance.Novel Diagnosis of Lyme Disease: Potential for CAM Intervention.Toll-like receptors in autoimmunity.Activation-induced cytidine deaminase expression and activity in the absence of germinal centers: insights into hyper-IgM syndrome.Interleukin-17 and systemic lupus erythematosus: current concepts.The multi-faceted influences of estrogen on lymphocytes: toward novel immuno-interventions strategies for autoimmunity management.Signals that influence T follicular helper cell differentiation and function.Extension of the germinal center stage of B cell development promotes autoantibodies in BXD2 mice.Multiple checkpoints keep follicular helper T cells under control to prevent autoimmunity.IL-17 in systemic lupus erythematosusInterleukin-17 and its target genes: mechanisms of interleukin-17 function in disease.Activation-induced cytidine deaminase and aberrant germinal center selection in the development of humoral autoimmunitiesHormones and AID: balancing immunity and autoimmunity.Functions and Malfunctions of Mammalian DNA-Cytosine DeaminasesBoth CpG methylation and activation-induced deaminase are required for the fragility of the human bcl-2 major breakpoint region: implications for the timing of the breaks in the t(14;18) translocation.Cutting Edge: defective follicular exclusion of apoptotic antigens due to marginal zone macrophage defects in autoimmune BXD2 mice.Expression of activation-induced cytidine deaminase gene in B lymphocytes of patients with common variable immunodeficiency.Antibodies as predictors of complex autoimmune diseases and cancer.
P2860
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P2860
Overexpression of activation-induced cytidine deaminase in B cells is associated with production of highly pathogenic autoantibodies.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh-hant
name
Overexpression of activation-i ...... hly pathogenic autoantibodies.
@en
Overexpression of activation-i ...... hly pathogenic autoantibodies.
@nl
type
label
Overexpression of activation-i ...... hly pathogenic autoantibodies.
@en
Overexpression of activation-i ...... hly pathogenic autoantibodies.
@nl
prefLabel
Overexpression of activation-i ...... hly pathogenic autoantibodies.
@en
Overexpression of activation-i ...... hly pathogenic autoantibodies.
@nl
P2093
P1476
Overexpression of activation-i ...... hly pathogenic autoantibodies.
@en
P2093
Godwin Job
Hui-Chen Hsu
John D Mountz
Mary Ann V Accavitti-Loper
Pingar Yang
Robert H Carter
William E Grizzle
P304
P356
10.4049/JIMMUNOL.178.8.5357
P407
P577
2007-04-01T00:00:00Z