Sildenafil (Viagra) induces powerful cardioprotective effect via opening of mitochondrial K(ATP) channels in rabbits.
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Sildenafil and cardiomyocyte-specific cGMP signaling prevent cardiomyopathic changes associated with dystrophin deficiencySildenafil citrate increases myocardial cGMP content in rat heart, decreases its hypertrophic response to isoproterenol and decreases myocardial leak of creatine kinase and troponin TThe pleiotropic effects of phosphodiesterase 5 inhibitors on function and safety in patients with cardiovascular disease and hypertensionTherapeutic potential of PDE modulation in treating heart diseasePriming the proteasome by protein kinase G: a novel cardioprotective mechanism of sildenafilSirtuin 1 (SIRT1) activation mediates sildenafil induced delayed cardioprotection against ischemia-reperfusion injury in micePretreatment of sildenafil attenuates ischemia-reperfusion renal injury in ratsFiber type-specific nitric oxide protects oxidative myofibers against cachectic stimuliPivotal effects of phosphodiesterase inhibitors on myocyte contractility and viability in normal and ischemic hearts.PDE5 inhibitors enhance the lethality of standard of care chemotherapy in pediatric CNS tumor cells.Phosphodiesterase-5 inhibition mimics intermittent reoxygenation and improves cardioprotection in the hypoxic myocardium.Neuroprotective effects of tadalafil on gerbil dopaminergic neurons following cerebral ischemiaLong-acting phosphodiesterase-5 inhibitor tadalafil attenuates doxorubicin-induced cardiomyopathy without interfering with chemotherapeutic effect.Understanding of chest pain in microvascular disease proved by cardiac magnetic resonance image (UMPIRE): study protocol for a randomized controlled trial.Phospholemman Ser69 phosphorylation contributes to sildenafil-induced cardioprotection against reperfusion injury.Chronic treatment with long acting phosphodiesterase-5 inhibitor tadalafil alters proteomic changes associated with cytoskeletal rearrangement and redox regulation in Type 2 diabetic hearts.Sildenafil increases chemotherapeutic efficacy of doxorubicin in prostate cancer and ameliorates cardiac dysfunction.cGMP-dependent protein kinases and cGMP phosphodiesterases in nitric oxide and cGMP action.Targeting cyclic nucleotide phosphodiesterase in the heart: therapeutic implications.Cyclic guanosine monophosphate signaling and phosphodiesterase-5 inhibitors in cardioprotection.Anti-inflammatory and cardioprotective effects of tadalafil in diabetic miceRole of microRNAs in cardiac preconditioningAdenosine A(1) receptor mediates delayed cardioprotective effect of sildenafil in mouse.Phosphodiesterase-5 inhibitor, tadalafil, protects against myocardial ischemia/reperfusion through protein-kinase g-dependent generation of hydrogen sulfideDevelopment of Therapeutics That Induce Mitochondrial Biogenesis for the Treatment of Acute and Chronic Degenerative Diseases.Sildenafil and vardenafil but not nitroglycerin limit myocardial infarction through opening of mitochondrial K(ATP) channels when administered at reperfusion following ischemia in rabbitsThe protective effects of a phosphodiesterase 5 inhibitor, sildenafil, on postresuscitation cardiac dysfunction of cardiac arrest: metabolic evidence from microdialysis.Attenuation of Doxorubicin-induced Cardiotoxicity by Tadalafil: A Long Acting Phosphodiesterase-5 Inhibitor.Mitigation of the progression of heart failure with sildenafil involves inhibition of RhoA/Rho-kinase pathwayThe effects of tadalafil on renal ischemia reperfusion injury: an experimental study.Emerging new uses of phosphodiesterase-5 inhibitors in cardiovascular diseases.Targeted disruption of PDE3B, but not PDE3A, protects murine heart from ischemia/reperfusion injury.Evidence for mitochondrial K+ channels and their role in cardioprotection.PDE5 inhibitors as therapeutics for heart disease, diabetes and cancerCinaciguat, a novel activator of soluble guanylate cyclase, protects against ischemia/reperfusion injury: role of hydrogen sulfide.Impact of Mitochondrial Ca2+-Sensitive Potassium (mBKCa) Channels in Sildenafil-Induced Cardioprotection in Rats.Cardiac role of cyclic-GMP hydrolyzing phosphodiesterase type 5: from experimental models to clinical trials.Past, present, and future: a 7-year update of Viagra (sildenafil citrate).Cyclic GMP and protein kinase-G in myocardial ischaemia-reperfusion: opportunities and obstacles for survival signaling.Cardioprotective actions of cyclic GMP: lessons from genetic animal models.
P2860
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P2860
Sildenafil (Viagra) induces powerful cardioprotective effect via opening of mitochondrial K(ATP) channels in rabbits.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh-hant
name
Sildenafil (Viagra) induces po ...... al K(ATP) channels in rabbits.
@en
type
label
Sildenafil (Viagra) induces po ...... al K(ATP) channels in rabbits.
@en
prefLabel
Sildenafil (Viagra) induces po ...... al K(ATP) channels in rabbits.
@en
P2093
P2860
P1476
Sildenafil (Viagra) induces po ...... al K(ATP) channels in rabbits.
@en
P2093
Fadi Salloum
John Hawkins
Rakesh C Kukreja
Ramzi Ockaili
P2860
P304
P356
10.1152/AJPHEART.00324.2002
P577
2002-09-01T00:00:00Z