Impact of incorporating the 2C5 crystal structure into comparative models of cytochrome P450 2D6.
about
Crystal structure of human cytochrome P450 2D6Integrated structure- and ligand-based in silico approach to predict inhibition of cytochrome P450 2D6.New insights into the structural characteristics and functional relevance of the human cytochrome P450 2D6 enzyme.Insights into drug metabolism by cytochromes P450 from modelling studies of CYP2D6-drug interactions.Modeling kinetics of subcellular disposition of chemicals.Mechanism-based inactivation of CYP2B1 and its F-helix mutant by two tert-butyl acetylenic compounds: covalent modification of prosthetic heme versus apoprotein.State-of-the-art tools for computational site of metabolism predictions: comparative analysis, mechanistical insights, and future applications.IDSite: An accurate approach to predict P450-mediated drug metabolism.Phe120 contributes to the regiospecificity of cytochrome P450 2D6: mutation leads to the formation of a novel dextromethorphan metabolite.Role of conserved Asp293 of cytochrome P450 2C9 in substrate recognition and catalytic activity.Residues glutamate 216 and aspartate 301 are key determinants of substrate specificity and product regioselectivity in cytochrome P450 2D6.CYP isoform specificity toward drug metabolism: analysis using common feature hypothesis.Why is quinidine an inhibitor of cytochrome P450 2D6? The role of key active-site residues in quinidine binding.AmineDB: large scale docking of amines with CYP2D6 and scoring for druglike properties--towards defining the scope of the chemical defense against foreign amines in humans.
P2860
Q24298673-EC5DBCBA-506B-4AF2-BFA9-ED0F360E4286Q30378479-F67FE743-8E28-42F3-9ABE-C9116BAB609CQ34994964-B0746FAA-B0C7-4B56-9E47-2E928BE86631Q36497020-D8A3970F-F24B-4BB0-B68C-27A565775906Q37194304-975C4E76-750F-49DD-A137-B9E46671FB37Q37416467-459FA773-1B06-4AFF-A182-77F92F204D60Q40233237-F4B4FE0C-A390-4092-BA2D-6FC70E92F638Q40257000-A3DCF5A1-0737-4C30-988C-B31FD0B9F9DCQ42103895-1FC0C872-82FF-4174-AF94-72AA1C8470F1Q43002752-500599F0-9330-4BCF-8290-B95631670FF0Q44226094-B130B364-5E68-434A-80EF-7B7C0A8B7D2FQ44784776-8D1A2315-BA91-4666-97F8-B31A8F95DD11Q46703082-3CE5E41F-0A7D-4478-8182-DC5FD8879E45Q51910625-A921CC36-2322-40C1-8442-F7B211DF6304
P2860
Impact of incorporating the 2C5 crystal structure into comparative models of cytochrome P450 2D6.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh
2002年學術文章
@zh-hant
name
Impact of incorporating the 2C ...... models of cytochrome P450 2D6.
@en
Impact of incorporating the 2C ...... models of cytochrome P450 2D6.
@nl
type
label
Impact of incorporating the 2C ...... models of cytochrome P450 2D6.
@en
Impact of incorporating the 2C ...... models of cytochrome P450 2D6.
@nl
prefLabel
Impact of incorporating the 2C ...... models of cytochrome P450 2D6.
@en
Impact of incorporating the 2C ...... models of cytochrome P450 2D6.
@nl
P2093
P2860
P356
P1433
P1476
Impact of incorporating the 2C ...... models of cytochrome P450 2D6
@en
P2093
Carol A Kemp
Nicholas P Tomkinson
Steven St-Gallay
P2860
P304
P356
10.1002/PROT.10192
P407
P577
2002-11-01T00:00:00Z