Evidence that accumulation of ceramides and cholesterol esters mediates oxidative stress-induced death of motor neurons in amyotrophic lateral sclerosis. - Wikidata - awgldk - TriplyDB

Evidence that accumulation of ceramides and cholesterol esters mediates oxidative stress-induced death of motor neurons in amyotrophic lateral sclerosis.

Evidence that accumulation of ceramides and cholesterol esters mediates oxidative stress-induced death of motor neurons in amyotrophic lateral sclerosis.

http://www.wikidata.org/entity/Q44153760

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Cholesterol homeostasis: a key to prevent or slow down neurodegeneration A galactosylceramide binding domain is involved in trafficking of CLN3 from Golgi to rafts via recycling endosomes Plumbagin, a novel Nrf2/ARE activator, protects against cerebral ischemia Proteomic profiling of cerebrospinal fluid identifies biomarkers for amyotrophic lateral sclerosis ALS-associated mutant SOD1G93A causes mitochondrial vacuolation by expansion of the intermembrane space and by involvement of SOD1 aggregation and peroxisomes Assessment of multifunctional contrast agent probes in neuroimaging: Implications of nanopharmaceutical therapeutic interventions Redox regulation in amyotrophic lateral sclerosis The GARP complex is required for cellular sphingolipid homeostasis.Inactivation of liver X receptor beta leads to adult-onset motor neuron degeneration in male mice Cellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disorders Mitochondrial lipids in neurodegeneration Cambinol, a novel inhibitor of neutral sphingomyelinase 2 shows neuroprotective properties Tumor necrosis factor-alpha-induced neutral sphingomyelinase-2 modulates synaptic plasticity by controlling the membrane insertion of NMDA receptors.Minireview: liver X receptor beta: emerging roles in physiology and diseases.Mammalian sphingosine kinase (SphK) isoenzymes and isoform expression: challenges for SphK as an oncotarget.Loss of ATF2 function leads to cranial motoneuron degeneration during embryonic mouse development Knockdown of FABP5 mRNA decreases cellular cholesterol levels and results in decreased apoB100 secretion and triglyceride accumulation in ARPE-19 cells Detection and characterization of the product of hydroethidine and intracellular superoxide by HPLC and limitations of fluorescence Shared mechanisms between Drosophila peripheral nervous system development and human neurodegenerative diseases Plasma membrane sphingomyelin hydrolysis increases hippocampal neuron excitability by sphingosine-1-phosphate mediated mechanisms.Involvement of ceramide in ethanol-induced apoptotic neurodegeneration in the neonatal mouse brain Are there roles for brain cell senescence in aging and neurodegenerative disorders?Sphingolipid metabolism regulates development and lifespan in Caenorhabditis elegans.Targeting cholesterol homeostasis to fight hearing loss: a new perspective.Alterations of the sphingolipid pathway in Alzheimer's disease: new biomarkers and treatment targets?Disturbance in cerebral spinal fluid sphingolipid content is associated with memory impairment in subjects infected with the human immunodeficiency virus Associative and predictive biomarkers of dementia in HIV-1-infected patients Glycosphingolipids are modulators of disease pathogenesis in amyotrophic lateral sclerosis Lysosomal and phagocytic activity is increased in astrocytes during disease progression in the SOD1 (G93A) mouse model of amyotrophic lateral sclerosis.Aberrant upregulation of astroglial ceramide potentiates oligodendrocyte injury.The mitochondrial uncoupler DNP triggers brain cell mTOR signaling network reprogramming and CREB pathway up-regulation Dysregulated expression of death, stress and mitochondrion related genes in the sciatic nerve of presymptomatic SOD1(G93A) mouse model of Amyotrophic Lateral Sclerosis.Molecular signatures of amyotrophic lateral sclerosis disease progression in hind and forelimb muscles of an SOD1(G93A) mouse model Ageing and neuronal vulnerability.Biomarkers for amyotrophic lateral sclerosis.Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease VAMP-associated Proteins (VAP) as Receptors That Couple Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Proteostasis with Lipid Homeostasis.Could plasma sphingolipids be diagnostic or prognostic biomarkers for Alzheimer's disease?Inhibition of serine palmitoyltransferase reduces Aβ and tau hyperphosphorylation in a murine model: a safe therapeutic strategy for Alzheimer's disease Liver X receptor beta (LXRbeta): a link between beta-sitosterol and amyotrophic lateral sclerosis-Parkinson's dementia

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Evidence that accumulation of ceramides and cholesterol esters mediates oxidative stress-induced death of motor neurons in amyotrophic lateral sclerosis.

http://www.wikidata.org/entity/Q44153760

description

2002 nî lūn-bûn

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2002年学术文章

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2002年學術文章

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name

Evidence that accumulation of ...... amyotrophic lateral sclerosis.

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Evidence that accumulation of ...... amyotrophic lateral sclerosis.

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Evidence that accumulation of ...... amyotrophic lateral sclerosis.

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Evidence that accumulation of ...... amyotrophic lateral sclerosis.

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Evidence that accumulation of ...... amyotrophic lateral sclerosis.

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Evidence that accumulation of ...... amyotrophic lateral sclerosis.

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Annals of Neurology

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Evidence that accumulation of ...... amyotrophic lateral sclerosis.

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Jeffrey D Rothstein

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Roy G Cutler

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Ward A Pedersen

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P2860

p53-dependent ceramide response to genotoxic stress

Mutations in SPTLC1, encoding serine palmitoyltransferase, long chain base subunit-1, cause hereditary sensory neuropathy type I

Epidemiology of mutations in superoxide dismutase in amyotrophic lateral sclerosis

Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1/myriocin

Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

Structural determination of glycosphingolipids as lithiated adducts by electrospray ionization mass spectrometry using low-energy collisional-activated dissociation on a triple stage quadrupole instrument.

Involvement of sphingomyelinases in TNF signaling pathways.

Plasma membrane redox system in the control of stress-induced apoptosis.

Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis.

Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo.

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448-457

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10.1002/ANA.10312

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4

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52

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Simonetta Camandola

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2002-10-01T00:00:00Z

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12325074

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amyotrophic lateral sclerosis