Cutting Edge: Targeting Epithelial ORMDL3 Increases, Rather than Reduces, Airway Responsiveness and Is Associated with Increased Sphingosine-1-Phosphate.

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Orosomucoid-like 3 (ORMDL3) upregulates airway smooth muscle proliferation, contraction, and Ca2+ oscillations in asthma.Lessons from ten years of genome-wide association studies of asthma.A decade of research on the 17q12-21 asthma locus: Piecing together the puzzle.

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P2860

Cutting Edge: Targeting Epithelial ORMDL3 Increases, Rather than Reduces, Airway Responsiveness and Is Associated with Increased Sphingosine-1-Phosphate.

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2017 nî lūn-bûn

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2017年の論文

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年學術文章

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Cutting Edge: Targeting Epithe ...... eased Sphingosine-1-Phosphate.

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Cutting Edge: Targeting Epithe ...... eased Sphingosine-1-Phosphate.

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Cutting Edge: Targeting Epithe ...... eased Sphingosine-1-Phosphate.

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Cutting Edge: Targeting Epithe ...... eased Sphingosine-1-Phosphate.

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Cutting Edge: Targeting Epithe ...... eased Sphingosine-1-Phosphate.

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Cutting Edge: Targeting Epithe ...... eased Sphingosine-1-Phosphate.

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P1476

Cutting Edge: Targeting Epithe ...... reased Sphingosine-1-Phosphate

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P2093

Andrew Beppu

http://www.w3.org/2001/XMLSchema#string

Arvin B Tam

http://www.w3.org/2001/XMLSchema#string

Christine Vuong

http://www.w3.org/2001/XMLSchema#string

David H Broide

http://www.w3.org/2001/XMLSchema#string

Hal M Hoffman

http://www.w3.org/2001/XMLSchema#string

James L Mueller

http://www.w3.org/2001/XMLSchema#string

Maho Niwa

http://www.w3.org/2001/XMLSchema#string

Marina Miller

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Matthew D McGeough

http://www.w3.org/2001/XMLSchema#string

Peter Rosenthal

http://www.w3.org/2001/XMLSchema#string

P2860

ORMDL3 is an inducible lung epithelial gene regulating metalloproteases, chemokines, OAS, and ATF6

ORMDL proteins are a conserved new family of endoplasmic reticulum membrane proteins

Orm family proteins mediate sphingolipid homeostasis

Pulmonary ORMDL3 is critical for induction of Alternaria-induced allergic airways disease.

Functional variants of the sphingosine-1-phosphate receptor 1 gene associate with asthma susceptibility

A specific sphingosine kinase 1 inhibitor attenuates airway hyperresponsiveness and inflammation in a mast cell-dependent murine model of allergic asthma

Fstl1 Promotes Asthmatic Airway Remodeling by Inducing Oncostatin M.

Targeted overexpression of parathyroid hormone-related peptide in chondrocytes causes chondrodysplasia and delayed endochondral bone formation.

ORMDL3 transgenic mice have increased airway remodeling and airway responsiveness characteristic of asthma.

Sphingosine 1-phosphate modulates human airway smooth muscle cell functions that promote inflammation and airway remodeling in asthma.

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3017-3022

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scholarly article

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10.4049/JIMMUNOL.1601848

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English

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198

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Taylor A Doherty

Ruth Gordillo

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2017-03-08T00:00:00Z

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28275141

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Cutting Edge: Targeting Epithelial ORMDL3 Increases, Rather than Reduces, Airway Responsiveness and Is Associated with Increased Sphingosine-1-Phosphate.

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P2860

P2860

Cutting Edge: Targeting Epithelial ORMDL3 Increases, Rather than Reduces, Airway Responsiveness and Is Associated with Increased Sphingosine-1-Phosphate.

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