Molecular principle of topotecan resistance by topoisomerase I mutations through molecular modeling approaches.
about
P-loop conformation governed crizotinib resistance in G2032R-mutated ROS1 tyrosine kinase: clues from free energy landscapeRevealing the favorable dissociation pathway of type II kinase inhibitors via enhanced sampling simulations and two-end-state calculations.Pharmacogenomics of second-line drugs used for treatment of unresponsive or relapsed osteosarcoma patients.Topoisomerases: Resistance versus Sensitivity, How Far We Can Go?Exploring resistance mechanisms of HCV NS3/4A protease mutations to MK5172: insight from molecular dynamics simulations and free energy calculations.How Does the L884P Mutation Confer Resistance to Type-II Inhibitors of JAK2 Kinase: A Comprehensive Molecular Modeling Study.Importance of protein flexibility on molecular recognition: modeling binding mechanisms of aminopyrazine inhibitors to Nek2.Theoretical studies on the selective mechanisms of GSK3β and CDK2 by molecular dynamics simulations and free energy calculations.Substitutions in Spodoptera exigua topoisomerase I modulate its relaxation activity and camptothecin sensitivity.Molecular principle of the cyclin-dependent kinase selectivity of 4-(thiazol-5-yl)-2-(phenylamino) pyrimidine-5-carbonitrile derivatives revealed by molecular modeling studies.
P2860
Q28540825-4E60262B-BFD2-468B-B1F3-5D620CA47FD6Q35080674-3382A57D-FA03-47B4-B479-0E78569C3C15Q38791215-797E507A-F586-437B-8675-B06162F13487Q38968355-AA42D506-C99C-4DD1-AE53-4048AD8B7F87Q40685694-53BEAF44-DE3F-490D-A742-F747E769E0C1Q41490661-55FB3FD2-7835-4B56-8BD9-6BB58AA0F3DBQ47225930-D5CBCDCC-1358-431A-B3FA-769D270D6779Q48930138-E79107A6-D3DE-41AE-936E-F02A19418630Q52857650-7CDC9777-8CDD-45CF-A902-58A20C814A34Q55033883-9A9E1E84-8143-485D-BE48-2D8F6DF8E2C1
P2860
Molecular principle of topotecan resistance by topoisomerase I mutations through molecular modeling approaches.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年学术文章
@wuu
2013年学术文章
@zh
2013年学术文章
@zh-cn
2013年学术文章
@zh-hans
2013年学术文章
@zh-my
2013年学术文章
@zh-sg
2013年學術文章
@yue
2013年學術文章
@zh-hant
name
Molecular principle of topotec ...... molecular modeling approaches.
@en
Molecular principle of topotec ...... molecular modeling approaches.
@nl
type
label
Molecular principle of topotec ...... molecular modeling approaches.
@en
Molecular principle of topotec ...... molecular modeling approaches.
@nl
prefLabel
Molecular principle of topotec ...... molecular modeling approaches.
@en
Molecular principle of topotec ...... molecular modeling approaches.
@nl
P2093
P356
P1476
Molecular principle of topotec ...... molecular modeling approaches.
@en
P2093
Huidong Yu
Huiyong Sun
Peichen Pan
P304
P356
10.1021/CI400066X
P577
2013-04-03T00:00:00Z