Inactivation of the 2-oxo acid dehydrogenase complexes upon generation of intrinsic radical species.
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How mitochondria produce reactive oxygen speciesAn update on the role of mitochondrial α-ketoglutarate dehydrogenase in oxidative stressThiamin diphosphate-dependent enzymes: from enzymology to metabolic regulation, drug design and disease modelsThe determination and analysis of site-specific rates of mitochondrial reactive oxygen species production.Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release.Alpha-ketoglutarate dehydrogenase: a target and generator of oxidative stressα-Ketoglutarate dehydrogenase: a mitochondrial redox sensorGlutathionylation of α-ketoglutarate dehydrogenase: the chemical nature and relative susceptibility of the cofactor lipoic acid to modification.Calcium and mitochondrial reactive oxygen species generation: how to read the facts.Behavioral impact of the regulation of the brain 2-oxoglutarate dehydrogenase complex by synthetic phosphonate analog of 2-oxoglutarate: implications into the role of the complex in neurodegenerative diseases.Human 2-oxoglutarate dehydrogenase complex E1 component forms a thiamin-derived radical by aerobic oxidation of the enamine intermediate.Brain pyruvate and 2-oxoglutarate dehydrogenase complexes are mitochondrial targets of the CoA ester of the Refsum disease marker phytanic acid.A mitocentric view of Alzheimer's disease suggests multi-faceted treatmentsMetabolic control exerted by the 2-oxoglutarate dehydrogenase reaction: a cross-kingdom comparison of the crossroad between energy production and nitrogen assimilation.The role of mitochondrial function and cellular bioenergetics in ageing and disease2-Oxo acid dehydrogenase complexes in redox regulation.Cerebrometabolic abnormalities in Alzheimer's disease.Alpha-ketoglutarate dehydrogenase complex-dependent succinylation of proteins in neurons and neuronal cell lines.Interactions between mitochondrial reactive oxygen species and cellular glucose metabolism.Molecular mechanisms of the non-coenzyme action of thiamin in brain: biochemical, structural and pathway analysis.Mitochondrial complex II can generate reactive oxygen species at high rates in both the forward and reverse reactionsElectrophilic aldehydes generated by sperm metabolism activate mitochondrial reactive oxygen species generation and apoptosis by targeting succinate dehydrogenase.Native rates of superoxide production from multiple sites in isolated mitochondria measured using endogenous reporters.A survey of oxidative paracatalytic reactions catalyzed by enzymes that generate carbanionic intermediates: implications for ROS production, cancer etiology, and neurodegenerative diseases.Aging: a shift from redox regulation to oxidative damage.Sites of reactive oxygen species generation by mitochondria oxidizing different substratesInhibition of mitochondrial 2-oxoglutarate dehydrogenase impairs viability of cancer cells in a cell-specific metabolism-dependent manner.The 2-oxoacid dehydrogenase complexes in mitochondria can produce superoxide/hydrogen peroxide at much higher rates than complex IMitochondrial glutathione depletion reveals a novel role for the pyruvate dehydrogenase complex as a key H2O2-emitting source under conditions of nutrient overload.Inhibitors of succinate: quinone reductase/Complex II regulate production of mitochondrial reactive oxygen species and protect normal cells from ischemic damage but induce specific cancer cell death.Lipoic acid and lipoic acid analogs in cancer metabolism and chemotherapy.Induction of mitochondrial reactive oxygen species production by GSH mediated S-glutathionylation of 2-oxoglutarate dehydrogenase.Pyruvate dehydrogenase complex and nicotinamide nucleotide transhydrogenase constitute an energy-consuming redox circuit.Accumulation of electrophilic aldehydes during postovulatory aging of mouse oocytes causes reduced fertility, oxidative stress, and apoptosis.Pyocyanin alters redox homeostasis and carbon flux through central metabolic pathways in Pseudomonas aeruginosa PA14.Formation of reactive oxygen species by human and bacterial pyruvate and 2-oxoglutarate dehydrogenase multienzyme complexes reconstituted from recombinant components.Lipoic acid metabolism and mitochondrial redox regulation.Blue light induces mitochondrial DNA damage and free radical production in epithelial cells.Characteristics of alpha-glycerophosphate-evoked H2O2 generation in brain mitochondria.Reactive oxygen species and energy machinery: an integrated dynamic model.
P2860
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P2860
Inactivation of the 2-oxo acid dehydrogenase complexes upon generation of intrinsic radical species.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh-hant
name
Inactivation of the 2-oxo acid ...... of intrinsic radical species.
@en
Inactivation of the 2-oxo acid ...... of intrinsic radical species.
@nl
type
label
Inactivation of the 2-oxo acid ...... of intrinsic radical species.
@en
Inactivation of the 2-oxo acid ...... of intrinsic radical species.
@nl
prefLabel
Inactivation of the 2-oxo acid ...... of intrinsic radical species.
@en
Inactivation of the 2-oxo acid ...... of intrinsic radical species.
@nl
P2860
P1433
P1476
Inactivation of the 2-oxo acid ...... of intrinsic radical species.
@en
P2093
Christian Sievers
Victoria I Bunik
P2860
P304
P356
10.1046/J.1432-1033.2002.03204.X
P407
P577
2002-10-01T00:00:00Z