Minimal impact of a de novo-expressed beta-cell autoantigen on spontaneous diabetes development in NOD mice.
about
Genetic-induced variations in the GAD65 T-cell repertoire governs efficacy of anti-CD3/GAD65 combination therapy in new-onset type 1 diabetes.Beta-cell specific production of IL6 in conjunction with a mainly intracellular but not mainly surface viral protein causes diabetes.Expression level of a pancreatic neo-antigen in beta cells determines degree of diabetes pathogenesis.Viral infection prevents diabetes by inducing regulatory T cells through NKT cell-plasmacytoid dendritic cell interplay.Nonviral delivery of small interfering RNA into pancreas-associated immune cells prevents autoimmune diabetes.Immunoregulatory mechanisms triggered by viral infections protect from type 1 diabetes in miceViruses and cytotoxic T lymphocytes in type 1 diabetes.Mechanisms of diabetic autoimmunity: I--the inductive interface between islets and the immune system at onset of inflammation.Interleukin-21 receptor-mediated signals control autoreactive T cell infiltration in pancreatic islets.99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: viruses, autoimmunity and immunoregulation.
P2860
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P2860
Minimal impact of a de novo-expressed beta-cell autoantigen on spontaneous diabetes development in NOD mice.
description
2007 nî lūn-bûn
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name
Minimal impact of a de novo-ex ...... betes development in NOD mice.
@en
Minimal impact of a de novo-ex ...... betes development in NOD mice.
@nl
type
label
Minimal impact of a de novo-ex ...... betes development in NOD mice.
@en
Minimal impact of a de novo-ex ...... betes development in NOD mice.
@nl
prefLabel
Minimal impact of a de novo-ex ...... betes development in NOD mice.
@en
Minimal impact of a de novo-ex ...... betes development in NOD mice.
@nl
P2093
P356
P1433
P1476
Minimal impact of a de novo-ex ...... abetes development in NOD mice
@en
P2093
Amy E Juedes
Christoph Huber
Damien Bresson
Eleanor Ling
Kresten Skak
Lisa Togher
Marianne M Martinic
Matthias G von Herrath
Mette Ejrnaes
P304
P356
10.2337/DB05-0062
P407
P577
2007-04-01T00:00:00Z