cAMP-activated protein kinase-independent potentiation of insulin secretion by cAMP is impaired in SUR1 null islets.
about
Structure-guided design of selective Epac1 and Epac2 agonistsRegulation of glucose homeostasis by GLP-1Epac: A new cAMP-binding protein in support of glucagon-like peptide-1 receptor-mediated signal transduction in the pancreatic beta-cellcAMP sensor Epac as a determinant of ATP-sensitive potassium channel activity in human pancreatic beta cells and rat INS-1 cells.Cell physiology of cAMP sensor Epac.Beta-cell-targeted overexpression of phosphodiesterase 3B in mice causes impaired insulin secretion, glucose intolerance, and deranged islet morphologyPKA-dependent potentiation of glucose-stimulated insulin secretion by Epac activator 8-pCPT-2'-O-Me-cAMP-AM in human islets of Langerhans.New insights concerning the glucose-dependent insulin secretagogue action of glucagon-like peptide-1 in pancreatic beta-cells.Regulation of sodium-proton exchanger isoform 3 (NHE3) by PKA and exchange protein directly activated by cAMP (EPAC).Epac2-dependent rap1 activation and the control of islet insulin secretion by glucagon-like peptide-1.PKA-dependent and PKA-independent pathways for cAMP-regulated exocytosis.The role of incretins in glucose homeostasis and diabetes treatment.The adenylyl cyclase inhibitor MDL-12,330A potentiates insulin secretion via blockade of voltage-dependent K(+) channels in pancreatic beta cellsActivation of the GLP-1 receptor signalling pathway: a relevant strategy to repair a deficient beta-cell massNADPH oxidase NOX2 defines a new antagonistic role for reactive oxygen species and cAMP/PKA in the regulation of insulin secretion.SUR1 regulates PKA-independent cAMP-induced granule priming in mouse pancreatic B-cellsNovel de novo mutation in sulfonylurea receptor 1 presenting as hyperinsulinism in infancy followed by overt diabetes in early adolescenceA mouse model of human hyperinsulinism produced by the E1506K mutation in the sulphonylurea receptor SUR1.Review. SUR1: a unique ATP-binding cassette protein that functions as an ion channel regulator.Regulation of insulin synthesis and secretion and pancreatic Beta-cell dysfunction in diabetes.Molecular physiology of glucagon-like peptide-1 insulin secretagogue action in pancreatic β cells.K(ATP) channels and islet hormone secretion: new insights and controversies.Exendin-(9-39) corrects fasting hypoglycemia in SUR-1-/- mice by lowering cAMP in pancreatic beta-cells and inhibiting insulin secretion.Restitution of defective glucose-stimulated insulin release of sulfonylurea type 1 receptor knockout mice by acetylcholine.Glucose stimulates Ca2+ influx and insulin secretion in 2-week-old beta-cells lacking ATP-sensitive K+ channels.Overnight culture unmasks glucose-induced insulin secretion in mouse islets lacking ATP-sensitive K+ channels by improving the triggering Ca2+ signal.A mutation in KCNJ11 causing human hyperinsulinism (Y12X) results in a glucose-intolerant phenotype in the mouse.A cAMP and Ca2+ coincidence detector in support of Ca2+-induced Ca2+ release in mouse pancreatic beta cells.Epinephrine-induced hyperpolarization of islet cells without KATP channels.Oscillations of membrane potential and cytosolic Ca(2+) concentration in SUR1(-/-) beta cells.Docking and fusion of insulin secretory granules in SUR1 knock out mouse beta-cells observed by total internal reflection fluorescence microscopy.Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men.Regulation of KATP Channel Trafficking in Pancreatic β Cells by Protein Histidine Phosphorylation.Mouse Models of β-cell KATP Channel Dysfunction.Sulphonylurea receptor-1, sulphonylureas and amplification of insulin secretion by Epac activation in β cells.
P2860
Q21145700-4C4D2ACB-EED5-4B41-97BF-DAA15FA7E5FFQ24563430-524EE9BE-C56A-43D5-9307-7A7AAEA7E85BQ24619138-79AD2C83-F3AA-4303-9FEC-62DDBC63518BQ27863919-F36AA6AF-3001-4A30-B2ED-F3829FE14D6DQ27863934-B77FEBA3-345E-43A1-B10C-D1355C4122A4Q28594896-4BAF2733-357B-4EB2-9CEE-8F24F77DAECFQ33727405-A55C594E-7DB3-49AA-83BA-0E11A25D40AEQ34037472-9244D208-AC42-48FB-8CD3-E670A0550AE5Q34270706-480FA614-B5BB-40F1-AD2B-897FDF4A5317Q34436421-E28736D1-DB81-4E1F-9EF2-97B221E00AE0Q34453808-EBC3F885-CFB9-418A-B1E0-5922E87EB503Q34901533-19FB0587-EBED-4B71-8D84-AA617E842DACQ35035803-025F24A1-0E3F-43BD-9AFD-21D745166A63Q35055522-665DD25E-AB04-4045-AAFB-EB0933CBE902Q36339543-496AD766-D606-43C0-8573-47A76043781BQ36412388-67C8BE71-F432-40B9-8485-90AC3D520FBBQ36756556-4316C1B3-468A-4835-849E-7789048B8308Q37251122-513F7A40-0CF9-42C3-B4FD-EC4BCAB7D56FQ37319861-1E940083-7421-4D34-9DA0-87AC227783C5Q37603286-4789B483-D375-443F-A8C2-130DDDF2FB24Q37904176-D6F8B3ED-BD94-4257-9FAC-5FC2D4BE4B01Q38138370-F849D6B7-D855-4953-81BE-E3D07B95F2AFQ40420025-B1BA220A-0A81-4329-996F-4C9C29714A98Q42455931-58A696DB-F3D0-471A-B125-4A35E9308C3EQ42504895-F8361230-73D0-44DB-8ECA-7F841C0515F0Q42510214-FF1498F4-8C1D-45A5-9A71-FBBD3A0C470DQ42943015-10AE8122-EDD4-4D70-A8B7-030408AF64F0Q43239185-7F57FC98-882C-444B-B837-8B006D9B70EFQ44653222-4ECA8FB3-2B63-4BA2-B73A-57E0D810856DQ44762040-467ECAF8-DA88-4309-A825-BFAFA0B6C39BQ46367417-ECA853B8-C618-461A-A981-EF8DFFB754D6Q47322426-EAB704C2-9ECC-482D-A5ED-18D5EDCFDCF6Q50027125-D1330A2E-0F00-486B-8167-2791ECF943B2Q53324606-97F7F8D8-AB8B-4B15-9BCF-08371C4ADA94Q54233121-88D8448E-ACEB-46A3-9FD3-79372033C4BE
P2860
cAMP-activated protein kinase-independent potentiation of insulin secretion by cAMP is impaired in SUR1 null islets.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh-hant
name
cAMP-activated protein kinase- ...... impaired in SUR1 null islets.
@en
cAMP-activated protein kinase- ...... impaired in SUR1 null islets.
@nl
type
label
cAMP-activated protein kinase- ...... impaired in SUR1 null islets.
@en
cAMP-activated protein kinase- ...... impaired in SUR1 null islets.
@nl
prefLabel
cAMP-activated protein kinase- ...... impaired in SUR1 null islets.
@en
cAMP-activated protein kinase- ...... impaired in SUR1 null islets.
@nl
P2093
P1433
P1476
cAMP-activated protein kinase- ...... impaired in SUR1 null islets.
@en
P2093
Joseph Bryan
Lydia Aguilar-Bryan
Mitsuhiro Nakazaki
Susanne Ullrich
Victor Seghers
P304
P356
10.2337/DIABETES.51.12.3440
P407
P577
2002-12-01T00:00:00Z