The core domain of chemokines binds CCR5 extracellular domains while their amino terminus interacts with the transmembrane helix bundle. - Wikidata - awgldk - TriplyDB

The core domain of chemokines binds CCR5 extracellular domains while their amino terminus interacts with the transmembrane helix bundle.

The core domain of chemokines binds CCR5 extracellular domains while their amino terminus interacts with the transmembrane helix bundle.

http://www.wikidata.org/entity/Q44238580

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NMR mapping of RANTES surfaces interacting with CCR5 using linked extracellular domains A microdomain formed by the extracellular ends of the transmembrane domains promotes activation of the G protein-coupled alpha-factor receptor Binding modes of CCR5-targetting HIV entry inhibitors: partial and full antagonists Chemokines in Wound Healing and as Potential Therapeutic Targets for Reducing Cutaneous Scarring Elucidating a key anti-HIV-1 and cancer-associated axis: the structure of CCL5 (Rantes) in complex with CCR5.Human Macrophage Inflammatory Protein 3 : Protein and Peptide Nuclear Magnetic Resonance Solution Structures, Dimerization, Dynamics, and Anti-Infective Properties Structure of the CCR5 Chemokine Receptor-HIV Entry Inhibitor Maraviroc Complex A Model of GAG/MIP-2/CXCR2 Interfaces and Its Functional Effects Constitutive activation of CCR5 and CCR2 induced by conformational changes in the conserved TXP motif in transmembrane helix 2.Small molecule receptor agonists and antagonists of CCR3 provide insight into mechanisms of chemokine receptor activation.Evidence of positive selection at codon sites localized in extracellular domains of mammalian CC motif chemokine receptor proteins.First pharmacophore model of CCR3 receptor antagonists and its homology model-assisted, stepwise virtual screening.Chemokine receptor oligomerization and allostery.Targeting spare CC chemokine receptor 5 (CCR5) as a principle to inhibit HIV-1 entry.Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery.Pharmacological characterization of a small-molecule agonist for the chemokine receptor CXCR3 Distinct functional sites for human immunodeficiency virus type 1 and stromal cell-derived factor 1alpha on CXCR4 transmembrane helical domains CCR5 antagonists: host-targeted antivirals for the treatment of HIV infection.Structures of human CCL18, CCL3, and CCL4 reveal molecular determinants for quaternary structures and sensitivity to insulin-degrading enzyme.Allosteric model of maraviroc binding to CC chemokine receptor 5 (CCR5).The attraction of chemokines as a target for specific anti-inflammatory therapy.CCR1 antagonists in clinical development.CCR5 mutations distinguish N-terminal modifications of RANTES (CCL5) with agonist versus antagonist activity.New concepts in drug discovery: collateral efficacy and permissive antagonism.Structure of human MIP-3alpha chemokine.Genetic and phenotypic analyses of human immunodeficiency virus type 1 escape from a small-molecule CCR5 inhibitor.Structural basis of chemokine receptor function--a model for binding affinity and ligand selectivity Rational design of novel HIV-1 entry inhibitors by RANTES engineering The differential sensitivity of human and rhesus macaque CCR5 to small-molecule inhibitors of human immunodeficiency virus type 1 entry is explained by a single amino acid difference and suggests a mechanism of action for these inhibitors The lupane-type triterpene 30-oxo-calenduladiol is a CCR5 antagonist with anti-HIV-1 and anti-chemotactic activities.Promiscuous drugs as therapeutics for chemokine receptors.Staphylococcus aureus Leukocidin LukED and HIV-1 gp120 Target Different Sequence Determinants on CCR5.Biology and clinical relevance of chemokines and chemokine receptors CXCR4 and CCR5 in human diseases.Chemokine oligomerization in cell signaling and migration.topPTM: a new module of dbPTM for identifying functional post-translational modifications in transmembrane proteins.Medicinal chemistry applied to a synthetic protein: development of highly potent HIV entry inhibitors.Chemokine oligomerization and interactions with receptors and glycosaminoglycans: the role of structural dynamics in function Targeting chemokine receptors in allergic disease.Pharmacological modulation of chemokine receptor function.HIV-1 Entry, Inhibitors, and Resistance

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P2860

The core domain of chemokines binds CCR5 extracellular domains while their amino terminus interacts with the transmembrane helix bundle.

http://www.wikidata.org/entity/Q44238580

description

2002 nî lūn-bûn

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2002年の論文

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年學術文章

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name

The core domain of chemokines ...... he transmembrane helix bundle.

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The core domain of chemokines ...... he transmembrane helix bundle.

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type

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The core domain of chemokines ...... he transmembrane helix bundle.

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The core domain of chemokines ...... he transmembrane helix bundle.

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The core domain of chemokines ...... he transmembrane helix bundle.

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The core domain of chemokines ...... he transmembrane helix bundle.

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Journal of Biological Chemistry

P1476

The core domain of chemokines ...... he transmembrane helix bundle.

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P2093

Amanda Proudfoot

http://www.w3.org/2001/XMLSchema#string

Anne De Leener

http://www.w3.org/2001/XMLSchema#string

Antoine Bondue

http://www.w3.org/2001/XMLSchema#string

Benjamin J Doranz

http://www.w3.org/2001/XMLSchema#string

Cédric Blanpain

http://www.w3.org/2001/XMLSchema#string

Cédric Govaerts

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Gilbert Vassart

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Robert W Doms

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P2860

The TXP motif in the second transmembrane helix of CCR5. A structural determinant of chemokine-induced activation

Monocyte chemotactic protein-2 activates CCR5 and blocks CD4/CCR5-mediated HIV-1 entry/replication

Molecular cloning and functional expression of a new human CC-chemokine receptor gene

Chemokines and disease

New targets for inhibitors of HIV-1 replication

Distinct but overlapping epitopes for the interaction of a CC-chemokine with CCR1, CCR3 and CCR5

Natural proteolytic processing of hemofiltrate CC chemokine 1 generates a potent CC chemokine receptor (CCR)1 and CCR5 agonist with anti-HIV properties

Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene

Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection

Close contacts with the endoplasmic reticulum as determinants of mitochondrial Ca2+ responses

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5179-5187

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10.1074/JBC.M205684200

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7

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278

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11005605

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12466283

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P921

transmembrane protein