Chemical synthesis of MT1 and MT7 muscarinic toxins: critical role of Arg-34 in their interaction with M1 muscarinic receptor.
about
Engineering of three-finger fold toxins creates ligands with original pharmacological profiles for muscarinic and adrenergic receptorsStructural model of ligand-G protein-coupled receptor (GPCR) complex based on experimental double mutant cycle data: MT7 snake toxin bound to dimeric hM1 muscarinic receptorIsolation and pharmacological characterization of AdTx1, a natural peptide displaying specific insurmountable antagonism of the alpha1A-adrenoceptor.Identification of a novel snake peptide toxin displaying high affinity and antagonist behaviour for the α2-adrenoceptors.Short- versus Long-Sarafotoxins: Two Structurally Related Snake Toxins with Very Different in vivo Haemodynamic EffectsMambalgin-1 Pain-relieving Peptide, Stepwise Solid-phase Synthesis, Crystal Structure, and Functional Domain for Acid-sensing Ion Channel 1a InhibitionRespiratory Effects of Sarafotoxins from the Venom of Different Atractaspis Genus Snake Species.Orthosteric binding of ρ-Da1a, a natural peptide of snake venom interacting selectively with the α1A-adrenoceptorFunctional M3 muscarinic acetylcholine receptors in mammalian heartsAdrenoceptor activity of muscarinic toxins identified from mamba venoms.Ancestral protein resurrection and engineering opportunities of the mamba aminergic toxinsSelective targeting of G-protein-coupled receptor subtypes with venom peptides.The three-finger toxin fold: a multifunctional structural scaffold able to modulate cholinergic functions.Molecular conversion of muscarinic acetylcholine receptor M(5) to muscarinic toxin 7 (MT7)-binding protein.Muscarinic toxin 7 selectivity is dictated by extracellular receptor loops.Structural determinants for the interactions between muscarinic toxin 7 and muscarinic acetylcholine receptors.Influence of MT7 toxin on the oligomerization state of the M1 muscarinic receptor.Green mamba peptide targets type-2 vasopressin receptor against polycystic kidney disease.Interaction of Synthetic Human SLURP-1 with the Nicotinic Acetylcholine Receptors.Interpreting the structural mechanism of action for MT7 and human muscarinic acetylcholine receptor 1 complex by modeling protein-protein interaction.Echocardiographic Evaluation of the Acute Cardiovascular Effects of an Endothelin-Like Peptide Extracted from the Venom of Atractaspis irregularis.A straightforward method for automated Fmoc-based synthesis of bio-inspired peptide crypto-thioesters.
P2860
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P2860
Chemical synthesis of MT1 and MT7 muscarinic toxins: critical role of Arg-34 in their interaction with M1 muscarinic receptor.
description
2003 nî lūn-bûn
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2003年の論文
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2003年学术文章
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name
Chemical synthesis of MT1 and ...... n with M1 muscarinic receptor.
@en
Chemical synthesis of MT1 and ...... n with M1 muscarinic receptor.
@nl
type
label
Chemical synthesis of MT1 and ...... n with M1 muscarinic receptor.
@en
Chemical synthesis of MT1 and ...... n with M1 muscarinic receptor.
@nl
prefLabel
Chemical synthesis of MT1 and ...... n with M1 muscarinic receptor.
@en
Chemical synthesis of MT1 and ...... n with M1 muscarinic receptor.
@nl
P2093
P356
P1476
Chemical synthesis of MT1 and ...... on with M1 muscarinic receptor
@en
P2093
André Ménez
Carole Fruchart-Gaillard
Gilles Mourier
P356
10.1124/MOL.63.1.26
P577
2003-01-01T00:00:00Z