Generation of an adenoviral vector containing an addition of a heterologous ligand to the serotype 3 fiber knob.
about
Mutation of the fiber shaft heparan sulphate binding site of a 5/3 chimeric adenovirus reduces liver tropism.Virotherapy using a novel chimeric oncolytic adenovirus prolongs survival in a human pancreatic cancer xenograft model.A phase I clinical trial of Ad5/3-Δ24, a novel serotype-chimeric, infectivity-enhanced, conditionally-replicative adenovirus (CRAd), in patients with recurrent ovarian cancerTargeting of adenovirus serotype 5 pseudotyped with short fiber from serotype 41 to c-erbB2-positive cells using bispecific single-chain diabody.Tropism modification of adenovirus vectors by peptide ligand insertion into various positions of the adenovirus serotype 41 short-fiber knob domain.Complex mosaicism is a novel approach to infectivity enhancement of adenovirus type 5-based vectors.
P2860
Generation of an adenoviral vector containing an addition of a heterologous ligand to the serotype 3 fiber knob.
description
2003 nî lūn-bûn
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name
Generation of an adenoviral ve ...... to the serotype 3 fiber knob.
@en
Generation of an adenoviral ve ...... to the serotype 3 fiber knob.
@nl
type
label
Generation of an adenoviral ve ...... to the serotype 3 fiber knob.
@en
Generation of an adenoviral ve ...... to the serotype 3 fiber knob.
@nl
prefLabel
Generation of an adenoviral ve ...... to the serotype 3 fiber knob.
@en
Generation of an adenoviral ve ...... to the serotype 3 fiber knob.
@nl
P2093
P2860
P356
P1433
P1476
Generation of an adenoviral ve ...... to the serotype 3 fiber knob.
@en
P2093
Elena Kashentseva
Igor Dmitriev
Joanne T Douglas
Marianne G Rots
Taco G Uil
Toshiro Seki
P2860
P2888
P304
P356
10.1038/SJ.CGT.7700543
P577
2003-02-01T00:00:00Z