Reduced affinity for Isoniazid in the S315T mutant of Mycobacterium tuberculosis KatG is a key factor in antibiotic resistance.
about
An oxyferrous heme/protein-based radical intermediate is catalytically competent in the catalase reaction of Mycobacterium tuberculosis catalase-peroxidase (KatG)Access channel residues Ser315 and Asp137 in Mycobacterium tuberculosis catalase-peroxidase (KatG) control peroxidatic activation of the pro-drug isoniazidCrystal structure of the catalase-peroxidase KatG W78F mutant from Synechococcus elongatus PCC7942 in complex with the antitubercular pro-drug isoniazidCrystal structure of Mycobacterium tuberculosis catalase-peroxidaseMechanisms of action of isoniazidMolecular patterns of multidrug resistance of Mycobacterium tuberculosis in Georgia.The Influence of HIV on the Evolution of Mycobacterium tuberculosis.Three-dimensional model and molecular mechanism of Mycobacterium tuberculosis catalase-peroxidase (KatG) and isoniazid-resistant KatG mutantsIsoniazid-resistance conferring mutations in Mycobacterium tuberculosis KatG: catalase, peroxidase, and INH-NADH adduct formation activitiesNovel katG mutations causing isoniazid resistance in clinical M. tuberculosis isolates.MolAxis: a server for identification of channels in macromoleculesAntibiotic resistance in Mycobacterium tuberculosis: peroxidase intermediate bypass causes poor isoniazid activation by the S315G mutant of M. tuberculosis catalase-peroxidase (KatG)Tackling Threats and Future Problems of Multidrug-Resistant Bacteria.Rifampin-isoniazid oligonucleotide typing: an alternative format for rapid detection of multidrug-resistant Mycobacterium tuberculosis.Isoniazid and thioacetazone may exhibit antitubercular activity by binding directly with the active site of mycolic acid cyclopropane synthase: Hypothesis based on computational analysis.Preliminary investigations of the effect of lipophilic analogues of the active metabolite of isoniazid toward bacterial and plasmodial strains.Rapid formation of compound II and a tyrosyl radical in the Y229F mutant of Mycobacterium tuberculosis catalase-peroxidase disrupts catalase but not peroxidase function.Relationship between mutation of serine residue at 315th position in M. tuberculosis catalase-peroxidase enzyme and Isoniazid susceptibility: an in silico analysis.Role of the main access channel of catalase-peroxidase in catalysis.Isoniazid metal complex reactivity and insights for a novel anti-tuberculosis drug design.
P2860
Q24644161-03A6806D-934D-47A5-A4C8-D3759F098327Q27680507-9D38A7F3-0D3D-4AC7-9F34-A62CF410598CQ27696333-BB8BD6EB-71D9-4EAD-8F1F-71A11A1622BDQ28487119-2D55E9C7-9236-4474-9298-C308378D2389Q29026436-FCA09DC0-B48D-4389-8154-97E30D8B47F9Q33703858-54B316A9-A870-4FA8-820F-6B4345E994C8Q33757201-43039707-4234-4CAB-9E06-C2CDFC6F21B3Q33832195-3934AD3A-DF3F-40F8-978C-B9AECBC6B5D2Q33836289-B2CF693B-6CFA-4E86-93BC-22925B78060EQ35909558-5E0F9847-9328-4F06-B3B1-AFDAD83A8812Q36749375-E3AD121D-ED99-41A9-B969-0E6DF0549F9FQ37269089-9D8E69D9-4B10-4E00-8D5F-34F9F75BCE67Q38842620-730A6FF0-F923-4396-911E-9691CAC99846Q39065330-84E856B3-8286-4E58-A548-5BEC8568D50EQ41911157-6DF2867F-0F9E-4023-9B61-7591B2D421EDQ42720655-60193BBC-75F1-44E6-BD32-C0DDDA62B2DBQ44565956-C78A6736-E746-430C-B9D1-363E29C98769Q46000312-C4809717-78EF-4053-9E80-4AF0D409CDDCQ50122764-E55DDF36-610B-4895-B351-5D0AC26073A9Q52616818-2B49DBC8-5D1D-470D-AD7C-E8C3AB93382B
P2860
Reduced affinity for Isoniazid in the S315T mutant of Mycobacterium tuberculosis KatG is a key factor in antibiotic resistance.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
Reduced affinity for Isoniazid ...... ctor in antibiotic resistance.
@en
Reduced affinity for Isoniazid ...... ctor in antibiotic resistance.
@nl
type
label
Reduced affinity for Isoniazid ...... ctor in antibiotic resistance.
@en
Reduced affinity for Isoniazid ...... ctor in antibiotic resistance.
@nl
prefLabel
Reduced affinity for Isoniazid ...... ctor in antibiotic resistance.
@en
Reduced affinity for Isoniazid ...... ctor in antibiotic resistance.
@nl
P2093
P2860
P356
P1476
Reduced affinity for Isoniazid ...... ctor in antibiotic resistance.
@en
P2093
Chiuhong Lee
Richard S Magliozzo
Shengwei Yu
Stefania Girotto
P2860
P304
14769-14775
P356
10.1074/JBC.M300326200
P407
P577
2003-02-13T00:00:00Z