about
Large-scale production and protein engineering of G protein-coupled receptors for structural studiesCrystal structure of rhodopsin bound to arrestin by femtosecond X-ray laserCrystal Structure of a Thermally Stable Rhodopsin MutantThe structural basis of agonist-induced activation in constitutively active rhodopsinStabilized G protein binding site in the structure of constitutively active metarhodopsin-IIStructural role of the T94I rhodopsin mutation in congenital stationary night blindnessFunctional role of positively selected amino acid substitutions in mammalian rhodopsin evolutionG-protein-coupled receptor structures were not built in a dayCharacteristics affecting expression and solubilization of yeast membrane proteinsMolecular assembly of rhodopsin with G protein-coupled receptor kinases.Rhodopsin TM6 can interact with two separate and distinct sites on arrestin: evidence for structural plasticity and multiple docking modes in arrestin-rhodopsin bindingMutations of the opsin gene (Y102H and I307N) lead to light-induced degeneration of photoreceptors and constitutive activation of phototransduction in mice.Photoactivation-induced instability of rhodopsin mutants T4K and T17M in rod outer segments underlies retinal degeneration in X. laevis transgenic models of retinitis pigmentosaRelocating the active-site lysine in rhodopsin and implications for evolution of retinylidene proteins.Conformational selection and equilibrium governs the ability of retinals to bind opsin.Crystallization scale preparation of a stable GPCR signaling complex between constitutively active rhodopsin and G-protein.Effect of channel mutations on the uptake and release of the retinal ligand in opsin.Low aqueous solubility of 11-cis-retinal limits the rate of pigment formation and dark adaptation in salamander rods.Preparation of an activated rhodopsin/transducin complex using a constitutively active mutant of rhodopsin.Constitutively active rhodopsin mutants causing night blindness are effectively phosphorylated by GRKs but differ in arrestin-1 bindingA constitutively activating mutation alters the dynamics and energetics of a key conformational change in a ligand-free G protein-coupled receptorDimerization deficiency of enigmatic retinitis pigmentosa-linked rhodopsin mutantsRetinitis pigmentosa mutants provide insight into the role of the N-terminal cap in rhodopsin folding, structure, and function.Decay of an active GPCR: Conformational dynamics govern agonist rebinding and persistence of an active, yet empty, receptor state.Assembly of an activated rhodopsin-transducin complex in nanoscale lipid bilayersLifting the lid on GPCRs: the role of extracellular loops.The Energetics of Chromophore Binding in the Visual Photoreceptor Rhodopsin.Stabilization of the human beta2-adrenergic receptor TM4-TM3-TM5 helix interface by mutagenesis of Glu122(3.41), a critical residue in GPCR structure.Nanoscale high-content analysis using compositional heterogeneities of single proteoliposomes.Constitutive phospholipid scramblase activity of a G protein-coupled receptorRelocating the Active-Site Lysine in Rhodopsin: 2. Evolutionary Intermediates.Structural impact of the E113Q counterion mutation on the activation and deactivation pathways of the G protein-coupled receptor rhodopsin.An improved rhodopsin/EGFP fusion protein for use in the generation of transgenic Xenopus laevis.Opsin activation as a cause of congenital night blindness.Role of the retinal hydrogen bond network in rhodopsin Schiff base stability and hydrolysis.The molecular and cellular basis of rhodopsin retinitis pigmentosa reveals potential strategies for therapy.Convergent selection pressures drive the evolution of rhodopsin kinetics at high altitudes via nonparallel mechanisms.Gi- and Gs-coupled GPCRs show different modes of G-protein binding.Deep-sea and pelagic rod visual pigments identified in the mysticete whales.Improved conformational stability of the visual G protein-coupled receptor rhodopsin by specific interaction with docosahexaenoic acid phospholipid.
P2860
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P2860
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
An opsin mutant with increased thermal stability.
@en
An opsin mutant with increased thermal stability.
@nl
type
label
An opsin mutant with increased thermal stability.
@en
An opsin mutant with increased thermal stability.
@nl
prefLabel
An opsin mutant with increased thermal stability.
@en
An opsin mutant with increased thermal stability.
@nl
P2093
P356
P1433
P1476
An opsin mutant with increased thermal stability.
@en
P2093
Alecia K Gross
Daniel D Oprian
P304
P356
10.1021/BI020611Z
P407
P577
2003-02-01T00:00:00Z