Tariquidar, a selective P-glycoprotein inhibitor, does not potentiate loperamide's opioid brain effects in humans despite full inhibition of lymphocyte P-glycoprotein.

Tariquidar, a selective P-glycoprotein inhibitor, does not potentiate loperamide's opioid brain effects in humans despite full inhibition of lymphocyte P-glycoprotein.

Item
http://www.wikidata.org/entity/Q44340794
Membrane transporters in drug developmentN-desmethyl-loperamide is selective for P-glycoprotein among three ATP-binding cassette transporters at the blood-brain barrierEffects of HM30181, a P-glycoprotein inhibitor, on the pharmacokinetics and pharmacodynamics of loperamide in healthy volunteers.Increased permeability-glycoprotein inhibition at the human blood-brain barrier can be safely achieved by performing PET during peak plasma concentrations of tariquidar.Factors Governing P-Glycoprotein-Mediated Drug-Drug Interactions at the Blood-Brain Barrier Measured with Positron Emission Tomography.A pilot study to assess the efficacy of tariquidar to inhibit P-glycoprotein at the human blood-brain barrier with (R)-11C-verapamil and PETSynthesis and in vivo evaluation of [11C]tariquidar, a positron emission tomography radiotracer based on a third-generation P-glycoprotein inhibitor.Imaging the function of P-glycoprotein with radiotracers: pharmacokinetics and in vivo applications.Drug interactions at the blood-brain barrier: fact or fantasy?P-glycoprotein related drug interactions: clinical importance and a consideration of disease states.Novel and emerging strategies in drug delivery for overcoming the blood-brain barrier.Efflux pump-mediated resistance in chemotherapy.The impact of P-gp functionality on non-steady state relationships between CSF and brain extracellular fluid.
P2860

Tariquidar, a selective P-glycoprotein inhibitor, does not potentiate loperamide's opioid brain effects in humans despite full inhibition of lymphocyte P-glycoprotein.

Item
http://www.wikidata.org/entity/Q44340794
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Tariquidar, a selective P-glyc ...... of lymphocyte P-glycoprotein.
@en
Tariquidar, a selective P-glyc ...... of lymphocyte P-glycoprotein.
@nl
type
label
Tariquidar, a selective P-glyc ...... of lymphocyte P-glycoprotein.
@en
Tariquidar, a selective P-glyc ...... of lymphocyte P-glycoprotein.
@nl
prefLabel
Tariquidar, a selective P-glyc ...... of lymphocyte P-glycoprotein.
@en
Tariquidar, a selective P-glyc ...... of lymphocyte P-glycoprotein.
@nl
P1433
P1476
P2093
P304
P31
P356
P407
P433
P478
P50
P577
P698
P921
P356
P1433
P1476
Tariquidar, a selective P-glyc ...... of lymphocyte P-glycoprotein.
@en
P2093
P304
P31
P356
10.1097/ALN.0B013E31818D8F28
P407
P433
P478
P50
P577
P698
P921