An antisense oligodeoxynucleotide to the delta opioid receptor (DOR-1) inhibits morphine tolerance and acute dependence in mice.
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Standard opioid agonists activate heteromeric opioid receptors: evidence for morphine and [d-Ala(2)-MePhe(4)-Glyol(5)]enkephalin as selective μ-δ agonistsOpioid ligands with mixed mu/delta opioid receptor interactions: an emerging approach to novel analgesicsMu and Delta opioid receptors activate the same G proteins in human neuroblastoma SH-SY5Y cellsAnti-analgesic effect of the mu/delta opioid receptor heteromer revealed by ligand-biased antagonismEvolution of the Bifunctional Lead μ Agonist / δ Antagonist Containing the Dmt-Tic Opioid PharmacophoreBi- or multifunctional opioid peptide drugs.The TIPP opioid peptide family: development of delta antagonists, delta agonists, and mixed mu agonist/delta antagonists.Putative kappa opioid heteromers as targets for developing analgesics free of adverse effects.How to design an opioid drug that causes reduced tolerance and dependence.Opioid-induced tolerance and dependence in mice is modulated by the distance between pharmacophores in a bivalent ligand seriesMitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2.Stabilization of morphine tolerance with long-term dosing: association with selective upregulation of mu-opioid receptor splice variant mRNAs.Recent advances on the δ opioid receptor: from trafficking to function.Implication of delta opioid receptor subtype 2 but not delta opioid receptor subtype 1 in the development of morphine analgesic tolerance in a rat model of chronic inflammatory pain.Development and in vitro characterization of a novel bifunctional μ-agonist/δ-antagonist opioid tetrapeptide.Synthesis and pharmacology of halogenated δ-opioid-selective [d-Ala(2)]deltorphin II peptide analoguesNaltrindole inhibits human multiple myeloma cell proliferation in vitro and in a murine xenograft model in vivoOpioid peptide-derived analgesicsDifferential involvement of enkephalins in analgesic tolerance, locomotor sensitization, and conditioned place preference induced by morphineAcute and chronic heroin dependence in mice: contribution of opioid and excitatory amino acid receptors.A survey of acute and chronic heroin dependence in ten inbred mouse strains: evidence of genetic correlation with morphine dependence.Potent and nontoxic antisense oligonucleotides containing locked nucleic acidsOn the g-protein-coupled receptor heteromers and their allosteric receptor-receptor interactions in the central nervous system: focus on their role in pain modulationMolecular Pharmacology of δ-Opioid Receptors.Discovery of novel triazole-based opioid receptor antagonists.Mu opioids and their receptors: evolution of a concept.Delta-opioid receptor antagonists prevent sensitization to the conditioned rewarding effects of morphine.Targeting endogenous mu- and delta-opioid receptor systems for the treatment of drug addiction.Pharmacological Profiles of Oligomerized μ-Opioid Receptors.Endomorphins: potential roles and therapeutic indications in the development of opioid peptide analgesic drugs.G-protein-coupled receptor type A heteromers as an emerging therapeutic target.The R7 subfamily of RGS proteins assists tachyphylaxis and acute tolerance at mu-opioid receptors.Plasma membrane cholesterol level and agonist-induced internalization of δ-opioid receptors; colocalization study with intracellular membrane markers of Rab family.Tuned-Affinity Bivalent Ligands for the Characterization of Opioid Receptor Heteromers.Pentapeptides displaying mu opioid receptor agonist and delta opioid receptor partial agonist/antagonist propertiesDevelopment of a universal high-throughput calcium assay for G-protein- coupled receptors with promiscuous G-protein Galpha15/16.Asymmetric synthesis and in vitro and in vivo activity of tetrahydroquinolines featuring a diverse set of polar substitutions at the 6 position as mixed-efficacy μ opioid receptor/δ opioid receptor ligands.An immunocytochemical-derived correlate for evaluating the bridging of heteromeric mu-delta opioid protomers by bivalent ligands.Disruption of δ-opioid receptor phosphorylation at threonine 161 attenuates morphine tolerance in rats with CFA-induced inflammatory hypersensitivity.Mediation of buprenorphine analgesia by a combination of traditional and truncated mu opioid receptor splice variants.
P2860
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P2860
An antisense oligodeoxynucleotide to the delta opioid receptor (DOR-1) inhibits morphine tolerance and acute dependence in mice.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh
1996年學術文章
@zh-hant
name
An antisense oligodeoxynucleot ...... and acute dependence in mice.
@en
An antisense oligodeoxynucleotide to the delta opioid receptor
@nl
type
label
An antisense oligodeoxynucleot ...... and acute dependence in mice.
@en
An antisense oligodeoxynucleotide to the delta opioid receptor
@nl
prefLabel
An antisense oligodeoxynucleot ...... and acute dependence in mice.
@en
An antisense oligodeoxynucleotide to the delta opioid receptor
@nl
P2093
P1476
An antisense oligodeoxynucleot ...... and acute dependence in mice.
@en
P2093
P304
P356
10.1016/0361-9230(95)02092-6
P577
1996-01-01T00:00:00Z