about
Morphine induces endocytosis of neuronal mu-opioid receptors through the sustained transfer of Galpha subunits to RGSZ2 proteinsRGS9 proteins facilitate acute tolerance to mu-opioid effectsEffector antagonism by the regulators of G protein signalling (RGS) proteins causes desensitization of mu-opioid receptors in the CNSRGS-Rz and RGS9-2 proteins control mu-opioid receptor desensitisation in CNS: the role of activated Galphaz subunitsActivation of mu-opioid receptors transfers control of Galpha subunits to the regulator of G-protein signaling RGS9-2: role in receptor desensitizationSupersensitivity to mu-opioid receptor-mediated inhibition of the adenylyl cyclase pathway involves pertussis toxin-resistant Galpha protein subunitsBehavioral, neurochemical and morphological changes induced by the overexpression of munc18-1a in brain of mice: relevance to schizophrenia.Myr+-Gi2 alpha and Go alpha subunits restore the efficacy of opioids, clonidine and neurotensin giving rise to antinociception in G-protein knock-down mice.Mu-opioid receptors transiently activate the Akt-nNOS pathway to produce sustained potentiation of PKC-mediated NMDAR-CaMKII signaling.SUMO-SIM interactions regulate the activity of RGSZ2 proteins.RGS14 prevents morphine from internalizing Mu-opioid receptors in periaqueductal gray neurons.Calcium/calmodulin-dependent protein kinase II supports morphine antinociceptive tolerance by phosphorylation of glycosylated phosducin-like protein.HINT1 protein cooperates with cannabinoid 1 receptor to negatively regulate glutamate NMDA receptor activity.Opiates as antidepressants.Direct association of Mu-opioid and NMDA glutamate receptors supports their cross-regulation: molecular implications for opioid tolerance.The plasticity of the association between mu-opioid receptor and glutamate ionotropic receptor N in opioid analgesic tolerance and neuropathic pain.Nitric oxide and zinc-mediated protein assemblies involved in mu opioid receptor signaling.In vivo modulation of G proteins and opioid receptor function by antisense oligodeoxynucleotides.The mu-opioid receptor and the NMDA receptor associate in PAG neurons: implications in pain control.NO-released zinc supports the simultaneous binding of Raf-1 and PKCγ cysteine-rich domains to HINT1 protein at the mu-opioid receptor.Antibodies and antisense oligodeoxynucleotides to mu-opioid receptors, selectively block the effects of mu-opioid agonists on intestinal transit and permeability in mice.RGSZ2 binds to the neural nitric oxide synthase PDZ domain to regulate mu-opioid receptor-mediated potentiation of the N-methyl-D-aspartate receptor-calmodulin-dependent protein kinase II pathway.Administration of myr(+)-G(i2)alpha subunits prevents acute tolerance (tachyphylaxis) to mu-opioid effects in mice.Agonists determine the pattern of G-protein activation in mu-opioid receptor-mediated supraspinal analgesia.Intrathecal pertussis toxin attenuates the morphine withdrawal syndrome in normal but not in arthritic rats.Sumoylated RGS-Rz proteins act as scaffolds for Mu-opioid receptors and G-protein complexes in mouse brain.Intrinsic analgesic activity of human beta lipotropin in rats: comparison with other opioid peptides.Mastoparan reduces the supraspinal analgesia mediated by mu/delta-opioid receptors in mice.NMDAR-nNOS generated zinc recruits PKCgamma to the HINT1-RGS17 complex bound to the C terminus of Mu-opioid receptors.The GBeta5 subunit that associates with the R7 subfamily of RGS proteins regulates mu-opioid effects.Brain-specific Galphaz interacts with Src tyrosine kinase to regulate Mu-opioid receptor-NMDAR signaling pathway.The delta2-opioid receptor subtype stimulates phosphoinositide metabolism in mouse periaqueductal gray matter.The histidine triad nucleotide-binding protein 1 supports mu-opioid receptor-glutamate NMDA receptor cross-regulation.Influence of Gz and Gi2 transducer proteins in the affinity of opioid agonists to mu receptors.Stimulation of mu- and delta-opioid receptors enhances phosphoinositide metabolism in mouse spinal cord: evidence for subtypes of delta-receptors.Expression of neural RGS-R7 and Gbeta5 Proteins in Response to Acute and Chronic Morphine.Transport of CSF antibodies to Galpha subunits across neural membranes requires binding to the target protein and protein kinase C activity.Local changes in GTP-binding protein immunoreactivities in human epileptogenic neocortex.GPCRs promote the release of zinc ions mediated by nNOS/NO and the redox transducer RGSZ2 protein.Dynorphin-(1-13): the effect of in vivo treatment on opiate bindings in vitro.
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Javier Garzón
@ast
Javier Garzón
@en
Javier Garzón
@es
Javier Garzón
@nl
Javier Garzón
@sl
type
label
Javier Garzón
@ast
Javier Garzón
@en
Javier Garzón
@es
Javier Garzón
@nl
Javier Garzón
@sl
prefLabel
Javier Garzón
@ast
Javier Garzón
@en
Javier Garzón
@es
Javier Garzón
@nl
Javier Garzón
@sl
P106
P108
P1153
7006191368
P21
P31
P496
0000-0002-0053-258X