L-homocysteine sulfinic acid and other acidic homocysteine derivatives are potent and selective metabotropic glutamate receptor agonists.
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Discovery of heterobicyclic templates for novel metabotropic glutamate receptor subtype 5 antagonistsChronic Glutamate Toxicity in Neurodegenerative Diseases-What is the Evidence?In silico molecular comparisons of C. elegans and mammalian pharmacology identify distinct targets that regulate feedingExcitotoxicity triggered by Neurobasal culture mediumThe cystine/glutamate antiporter system x(c)(-) in health and disease: from molecular mechanisms to novel therapeutic opportunities.Radiosynthesis and evaluation of an 18F-labeled positron emission tomography (PET) radioligand for metabotropic glutamate receptor subtype 4 (mGlu4).The glutamate agonist homocysteine sulfinic acid stimulates glucose uptake through the calcium-dependent AMPK-p38 MAPK-protein kinase C zeta pathway in skeletal muscle cellsAssociation between plasma homocysteine status and hypothyroidism: a meta-analysisIs hyperhomocysteinemia an Alzheimer's disease (AD) risk factor, an AD marker, or neither?Pharmacological characterization of mGlu1 receptors in cerebellar granule cells reveals biased agonism.Design and synthesis of novel heterobiaryl amides as metabotropic glutamate receptor subtype 5 antagonistsNitrative stress in cerebral endothelium is mediated by mGluR5 in hyperhomocysteinemiaEmerging evidence for a similar role of glutamate receptors in the nervous and immune systems.Screening the receptorome reveals molecular targets responsible for drug-induced side effects: focus on 'fen-phen'.Homocysteine-NMDA receptor-mediated activation of extracellular signal-regulated kinase leads to neuronal cell death.Synthesis and evaluation in monkey of [(18)F]4-fluoro-N-methyl-N-(4-(6-(methylamino)pyrimidin-4-yl)thiazol-2-yl)benzamide ([(18)F]FIMX): a promising radioligand for PET imaging of brain metabotropic glutamate receptor 1 (mGluR1)Motor complications, levodopa metabolism and progression of Parkinson's disease.Astroglial amino acid-based transmitter receptors.Glutamate receptors in the kidney.GluN2A Subunit-Containing NMDA Receptors Are the Preferential Neuronal Targets of Homocysteine.Metabotropic glutamate receptor 5 mediates phosphorylation of vascular endothelial cadherin and nuclear localization of β-catenin in response to homocysteineA metabolomic study on high-risk stroke patients determines low levels of serum lysine metabolites: a retrospective cohort study.Plasma low-molecular-weight thiol/disulphide homeostasis as an early indicator of global and focal cerebral ischaemia.Synthesis and evaluation of N-(methylthiophenyl)picolinamide derivatives as PET radioligands for metabotropic glutamate receptor subtype 4.The role of NMDA and mGluR5 receptors in calcium mobilization and neurotoxicity of homocysteine in trigeminal and cortical neurons and glial cells.Regulation of homocysteine-induced MMP-9 by ERK1/2 pathway.Anxiety-related behavior in hyperhomocysteinemia induced by methionine nutritional overload in rats: role of the brain oxidative stress.Hyperhomocysteinemia induced by methionine dietary nutritional overload modulates acetylcholinesterase activity in the rat brain.Homocysteine levels in schizophrenia patients newly admitted to an acute psychiatric ward.Glutamate Receptor Agonists and Glutamate Transporter Antagonists Regulate Differentiation of Osteoblast Lineage Cells.
P2860
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P2860
L-homocysteine sulfinic acid and other acidic homocysteine derivatives are potent and selective metabotropic glutamate receptor agonists.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
L-homocysteine sulfinic acid a ...... c glutamate receptor agonists.
@en
L-homocysteine sulfinic acid a ...... c glutamate receptor agonists.
@nl
type
label
L-homocysteine sulfinic acid a ...... c glutamate receptor agonists.
@en
L-homocysteine sulfinic acid a ...... c glutamate receptor agonists.
@nl
prefLabel
L-homocysteine sulfinic acid a ...... c glutamate receptor agonists.
@en
L-homocysteine sulfinic acid a ...... c glutamate receptor agonists.
@nl
P2093
P356
P1476
L-homocysteine sulfinic acid a ...... ic glutamate receptor agonists
@en
P2093
Bryan L Roth
Ewa Grajkowska
Jarda T Wroblewski
Jason E Savage
Joseph H Nadeau
Laura Rauser
Sandra J Hufeisen
P304
P356
10.1124/JPET.102.047092
P407
P577
2003-04-01T00:00:00Z