Somatic mutations in MLH1 and MSH2 are a frequent cause of mismatch-repair deficiency in Lynch syndrome-like tumors.
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Deficient mismatch repair: Read all about it (Review)Lynch syndrome and Lynch syndrome mimics: The growing complex landscape of hereditary colon cancerOpportunities for immunotherapy in microsatellite instable colorectal cancerThe genetic heterogeneity of colorectal cancer predisposition - guidelines for gene discoveryGenetics and Genetic Biomarkers in Sporadic Colorectal CancerCombined mismatch repair and POLE/POLD1 defects explain unresolved suspected Lynch syndrome cancersEndometrial cancer gene panels: clinical diagnostic vs research germline DNA testing.Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burdenScreening for mismatch repair deficiency in colorectal cancer: data from three academic medical centers.Patients with colorectal cancer associated with Lynch syndrome and MLH1 promoter hypermethylation have similar prognoses.Consequences of universal MSI/IHC in screening ENDOMETRIAL cancer patients for Lynch syndrome.The genetic basis of Lynch syndrome and its implications for clinical practice and risk management.Role of tumour molecular and pathology features to estimate colorectal cancer risk for first-degree relatives.Clinical problems of colorectal cancer and endometrial cancer cases with unknown cause of tumor mismatch repair deficiency (suspected Lynch syndrome)Colon and endometrial cancers with mismatch repair deficiency can arise from somatic, rather than germline, mutations.Germline variants in POLE are associated with early onset mismatch repair deficient colorectal cancerMismatch repair-deficient crypt foci in Lynch syndrome--molecular alterations and association with clinical parameters.Impact of an immunohistochemistry-based universal screening protocol for Lynch syndrome in endometrial cancer on genetic counseling and testing.Microsatellite instability use in mismatch repair gene sequence variant classificationWhole Gene Capture Analysis of 15 CRC Susceptibility Genes in Suspected Lynch Syndrome Patients.Molecular Features and Methylation Status in Early Onset (≤40 Years) Colorectal Cancer: A Population Based, Case-Control Study.Somatic mutations of the coding microsatellites within the beta-2-microglobulin gene in mismatch repair-deficient colorectal cancers and adenomas.Validation of Prediction Models for Mismatch Repair Gene Mutations in KoreansColorectal cancer carcinogenesis: a review of mechanismsUpdate on Lynch syndrome genomics.Screening adherence and cancer risk perceptions in colorectal cancer survivors with Lynch-like syndrome.Is it all Lynch syndrome?: An assessment of family history in individuals with mismatch repair-deficient tumors.Frequent PIK3CA Mutations in Colorectal and Endometrial Tumors With 2 or More Somatic Mutations in Mismatch Repair GenesEvolving approach and clinical significance of detecting DNA mismatch repair deficiency in colorectal carcinoma.Colorectal Choriocarcinoma in a Patient with Probable Lynch Syndrome.HEREDITARY, SPORADIC AND METASTATIC COLORECTAL CANCER ARE COMMONLY DRIVEN BY SPECIFIC SPECTRUMS OF DEFECTIVE DNA MISMATCH REPAIR COMPONENTS.Recent advances in understanding Lynch syndromeNovel Implications in Molecular Diagnosis of Lynch Syndrome.Molecular genetics of microsatellite-unstable colorectal cancer for pathologists.Next generation diagnostic molecular pathology: critical appraisal of quality assurance in Europe.Genetics, biomarkers, hereditary cancer syndrome diagnosis, heterogeneity and treatment: a review.Lynch syndrome: five unanswered questions.Lynch syndrome in the 21st century: clinical perspectives.Using Genetics to Identify Hereditary Colorectal Polyposis and Cancer Syndromes in Your Patient.DNA mismatch repair deficiency and hereditary syndromes in Latino patients with colorectal cancer.
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P2860
Somatic mutations in MLH1 and MSH2 are a frequent cause of mismatch-repair deficiency in Lynch syndrome-like tumors.
description
2013 nî lūn-bûn
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2013年の論文
@ja
2013年学术文章
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2013年学术文章
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2013年学术文章
@zh-cn
2013年学术文章
@zh-hans
2013年学术文章
@zh-my
2013年学术文章
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2013年學術文章
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name
Somatic mutations in MLH1 and ...... in Lynch syndrome-like tumors.
@en
Somatic mutations in MLH1 and ...... in Lynch syndrome-like tumors.
@nl
type
label
Somatic mutations in MLH1 and ...... in Lynch syndrome-like tumors.
@en
Somatic mutations in MLH1 and ...... in Lynch syndrome-like tumors.
@nl
prefLabel
Somatic mutations in MLH1 and ...... in Lynch syndrome-like tumors.
@en
Somatic mutations in MLH1 and ...... in Lynch syndrome-like tumors.
@nl
P2093
P50
P1433
P1476
Somatic mutations in MLH1 and ...... in Lynch syndrome-like tumors.
@en
P2093
Hicham Ouchene
Marjolijn J L Ligtenberg
Michael P Kwint
Monique Goossens
Sandra J B Hendriks-Cornelissen
Wendy A G van Zelst-Stams
P304
643-646.e8
P356
10.1053/J.GASTRO.2013.12.002
P407
P577
2013-12-10T00:00:00Z