Telomerase-deficient mice exhibit bone loss owing to defects in osteoblasts and increased osteoclastogenesis by inflammatory microenvironment.
about
The progress of early growth response factor 1 and leukemiaMesenchymal stem cells (MSCs) as skeletal therapeutics - an updateSkeletal stem cells and their contribution to skeletal fragility: senescence and rejuvenationMouse models of telomere dysfunction phenocopy skeletal changes found in human age-related osteoporosis.Mutations in CTC1, encoding the CTS telomere maintenance complex component 1, cause cerebroretinal microangiopathy with calcifications and cysts.Loss of the osteogenic differentiation potential during senescence is limited to bone progenitor cells and is dependent on p53.Bone marrow skeletal stem/progenitor cell defects in dyskeratosis congenita and telomere biology disorders.Aberrant gene expression profiles, during in vitro osteoblast differentiation, of telomerase deficient mouse bone marrow stromal stem cells (mBMSCs)Proliferation and differentiation of rat osteoporosis mesenchymal stem cells (MSCs) after telomerase reverse transcriptase (TERT) transfection.The convergence of fracture repair and stem cells: interplay of genes, aging, environmental factors and disease.Amlexanox Suppresses Osteoclastogenesis and Prevents Ovariectomy-Induced Bone Loss.Impairment of osteoblast differentiation due to proliferation-independent telomere dysfunction in mouse models of accelerated agingTelomerase activity promotes osteoblast differentiation by modulating IGF-signaling pathwayNa+/H+ exchanger regulatory factor 1 (NHERF1) directly regulates osteogenesis.The changing balance between osteoblastogenesis and adipogenesis in aging and its impact on hematopoiesisDNA damage drives accelerated bone aging via an NF-κB-dependent mechanism.From cellular senescence to age-associated diseases: the miRNA connection.The role of telomeres in musculoskeletal diseases.Advances in osteoimmunology: pathophysiologic concepts and treatment opportunities.Stem cell function and maintenance - ends that matter: role of telomeres and telomerase.Bone cell senescence: mechanisms and perspectives."Ins" and "Outs" of mesenchymal stem cell osteogenesis in regenerative medicine.Mouse embryonic fibroblasts (MEF) exhibit a similar but not identical phenotype to bone marrow stromal stem cells (BMSC).Mitochondrial metabolic failure in telomere attrition-provoked aging of bone marrow mesenchymal stem cells.Mammalian telomeres and their partnership with lamins.Implants for the aged patient: biological, clinical and sociological considerations.Abnormal Bone Acquisition With Early-Life HIV Infection: Role of Immune Activation and Senescent Osteogenic Precursors.DNA damage and senescence in osteoprogenitors expressing Osx1 may cause their decrease with age.Mice with reduced expression of the telomere-associated protein Ft1 develop p53-sensitive progeroid traits.
P2860
Q26748151-940281A2-EC80-426D-9332-3B2A11BF3665Q26753086-17C291D6-B257-4C41-A08E-C12AF6C04AD2Q26778170-E4B30972-7D96-4317-A35F-AB46D249287FQ33556010-C00B5772-5CE4-4E03-82F7-E336C230F6CDQ34258372-76A520BF-7273-46AC-9757-9CA4F3054349Q34979749-922D4517-970F-47DE-94D9-7276E4093FDCQ35029446-F68AB707-D234-4F4F-8D08-FA1240EAA715Q35052715-6DF5FBB1-3D10-4F86-BF5B-777923076D72Q35239972-2F5746A7-25FE-482B-994B-BC9827BD02ACQ35683050-4F2E0EA8-4409-4C0F-A32F-62E3E7D3CE43Q36026720-2C0CACA4-43C7-47D8-82C8-9A346D7ED0CBQ36103691-A818C5E8-7DEC-4158-AA96-B3EC8330D709Q36149431-70EE2399-0787-442E-8351-2880BBFDCD45Q36481723-3E345504-9DDE-411C-B0CA-6770A53C36F0Q36815204-73C206D4-A1C0-4BD3-9FFD-159D75E1EF62Q36872092-AD9137FA-672F-409D-9020-3F77C4A94197Q37581213-EACFEA27-D3B3-4A01-AC93-B902F3AEC816Q38042771-7ABD3632-5909-4FBC-9303-628FD0A1DCA1Q38047183-652ACDDF-04B7-4EC2-8499-FA333ED707FCQ38128471-82517275-FF1F-4EBD-9E38-718E037FE595Q38185298-3E6A93D2-DA7E-4DDA-A49F-1B313239E14CQ38207596-DC2BF011-71E8-4296-9335-808AB76AA86EQ38331808-80E52321-1F6A-4694-A428-8D328716F65CQ38590777-1264E53F-1FCA-4A22-AEDA-F07A806C3B9CQ38818114-C32AFF63-0532-42A0-915C-9787AF585B35Q38921860-E4CF4BEC-D5EC-442F-AC88-FBC533E308E3Q40708846-7D15D2C3-2C6D-49C8-9C73-04992AD08521Q40988880-CEE2F943-E076-401C-A81F-CCBFC977D3CFQ52595866-9F9E289F-1464-4609-A33A-27BFDFCA289A
P2860
Telomerase-deficient mice exhibit bone loss owing to defects in osteoblasts and increased osteoclastogenesis by inflammatory microenvironment.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
@zh-hant
name
Telomerase-deficient mice exhi ...... inflammatory microenvironment.
@en
Telomerase-deficient mice exhi ...... inflammatory microenvironment.
@nl
type
label
Telomerase-deficient mice exhi ...... inflammatory microenvironment.
@en
Telomerase-deficient mice exhi ...... inflammatory microenvironment.
@nl
prefLabel
Telomerase-deficient mice exhi ...... inflammatory microenvironment.
@en
Telomerase-deficient mice exhi ...... inflammatory microenvironment.
@nl
P2093
P2860
P356
P1476
Telomerase-deficient mice exhi ...... inflammatory microenvironment.
@en
P2093
Hamid Saeed
Michael Amling
Nicholas Ditzel
Philip Catala-Lehnen
Weimin Qiu
P2860
P304
P356
10.1002/JBMR.349
P577
2011-07-01T00:00:00Z