NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice.
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Ectopic PDX-1 expression directly reprograms human keratinocytes along pancreatic insulin-producing cells fateInduction of insulin secretion in engineered liver cells by nitric oxideThe diabetes-linked transcription factor PAX4 promotes {beta}-cell proliferation and survival in rat and human isletsCell therapies for pancreatic beta-cell replenishmentRecent Trends in Therapeutic Approaches for Diabetes Management: A Comprehensive UpdateMASH1/Ascl1a leads to GAP43 expression and axon regeneration in the adult CNSReversal of hyperglycemia by insulin-secreting rat bone marrow- and blastocyst-derived hypoblast stem cell-like cellsTranscription factor regulation of pancreatic organogenesis, differentiation and maturationEpigenetic Regulation of Islet Development and RegenerationGutless adenovirus: last-generation adenovirus for gene therapyNonvirally modified autologous primary hepatocytes correct diabetes and prevent target organ injury in a large preclinical modelAdult tissue sources for new β cells.A feat of metabolic proportions: Pdx1 orchestrates islet development and function in the maintenance of glucose homeostasis.Treatment of diabetes and long-term survival after insulin and glucokinase gene therapy.Reversal of hyperglycemia by protein transduction of NeuroD in vivo.Vector and helper genome rearrangements occur during production of helper-dependent adenoviral vectors.SiRNA Delivery with PEGylated Graphene Oxide Nanosheets for Combined Photothermal and Genetherapy for Pancreatic Cancer.Differentiation of human multipotent dermal fibroblasts into islet-like cell clusters.Protein therapy using MafA fused to a polyarginine transduction domain attenuates glucose levels of streptozotocin‑induced diabetic mice.Transplantation of betacellulin-transduced islets improves glucose intolerance in diabetic miceRegenerating pancreatic beta-cells: plasticity of adult pancreatic cells and the feasibility of in-vivo neogenesis.Hepatocyte nuclear factor-4alpha induces transdifferentiation of hematopoietic cells into hepatocytesBetacellulin induces increased retinal vascular permeability in miceA new method for generating insulin-secreting cells from human pancreatic epithelial cells after islet isolation transformed by NeuroD1.Cell-replacement therapy for diabetes: Generating functional insulin-producing tissue from adult human liver cells.Molecular engineering human hepatocytes into pancreatic beta cells for diabetes therapy.The fusion of bone-marrow-derived proinsulin-expressing cells with nerve cells underlies diabetic neuropathy.Stem cells as a therapeutic target for diabetes.Liver-directed gene therapy for dyslipidemia and diabetesRegeneration of pancreatic islets in vivo by ultrasound-targeted gene therapy.Stem cell approaches for the treatment of type 1 diabetes mellitus.Pancreatic stem/progenitor cells for the treatment of diabetes.Revealing transcription factors during human pancreatic β cell development.Direct lineage conversions: unnatural but useful?In vitro quantitative and relative gene expression analysis of pancreatic transcription factors Pdx-1, Ngn-3, Isl-1, Pax-4, Pax-6 and Nkx-6.1 in trans-differentiated human hepatic progenitorsA blueprint for engineering cell fate: current technologies to reprogram cell identity.Adenoviral vectors stimulate glucagon transcription in human mesenchymal stem cells expressing pancreatic transcription factors.Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity.Thyroid hormone potentiates insulin signaling and attenuates hyperglycemia and insulin resistance in a mouse model of type 2 diabetesMAFA controls genes implicated in insulin biosynthesis and secretion
P2860
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P2860
NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
NeuroD-betacellulin gene thera ...... and reverses diabetes in mice.
@en
NeuroD-betacellulin gene thera ...... and reverses diabetes in mice.
@nl
type
label
NeuroD-betacellulin gene thera ...... and reverses diabetes in mice.
@en
NeuroD-betacellulin gene thera ...... and reverses diabetes in mice.
@nl
prefLabel
NeuroD-betacellulin gene thera ...... and reverses diabetes in mice.
@en
NeuroD-betacellulin gene thera ...... and reverses diabetes in mice.
@nl
P2093
P356
P1433
P1476
NeuroD-betacellulin gene thera ...... and reverses diabetes in mice.
@en
P2093
Hideto Kojima
Hirotsugu Imaeda
Kazuhiro Matsumura
Lawrence Chan
Makiko Maeda
Mineko Fujimiya
Patrick Younan
P2888
P304
P356
10.1038/NM867
P407
P577
2003-04-21T00:00:00Z
P5875
P6179
1000982881