Role of specific muscarinic receptor subtypes in cholinergic parasympathomimetic responses, in vivo phosphoinositide hydrolysis, and pilocarpine-induced seizure activity.
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Nerve agent exposure elicits site-specific changes in protein phosphorylation in mouse brainSubtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disordersCentrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in ratsM1 receptors mediate cholinergic modulation of excitability in neocortical pyramidal neurons.Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity.Genome-wide association analysis of genetic generalized epilepsies implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32.Allosteric activators of muscarinic receptors as novel approaches for treatment of CNS disorders.Beyond the dopamine receptor: novel therapeutic targets for treating schizophrenia.A novel selective muscarinic acetylcholine receptor subtype 1 antagonist reduces seizures without impairing hippocampus-dependent learningSelective activation of the M1 muscarinic acetylcholine receptor achieved by allosteric potentiation.Convulsant bicuculline modifies CNS muscarinic receptor affinity.Combined scopolamine and ethanol treatment results in a locomotor stimulant response suggestive of synergism that is not blocked by dopamine receptor antagonists.Cortical M1 receptor concentration increases without a concomitant change in function in Alzheimer's disease.P2X7 receptor regulates leukocyte infiltrations in rat frontoparietal cortex following status epilepticus.M1 and M4 receptors modulate hippocampal pyramidal neurons.Muscarinic excitation of parvalbumin-positive interneurons contributes to the severity of pilocarpine-induced seizures.Muscarinic receptors: their distribution and function in body systems, and the implications for treating overactive bladderParkinson's disease therapeutics: new developments and challenges since the introduction of levodopa.Elimination of GRK2 from cholinergic neurons reduces behavioral sensitivity to muscarinic receptor activationTowards a muscarinic hypothesis of schizophrenia.Muscarinic receptors and ligands in cancer.The muscarinic acetylcholine receptor agonist BuTAC mediates antipsychotic-like effects via the M4 subtypeM-currents (Kv7.2-7.3/KCNQ2-KCNQ3) Are Responsible for Dysfunctional Autonomic Control in Hypertensive Rats.In vivo and in vitro effects of pilocarpine: relevance to ictogenesis.M5 receptor activation produces opposing physiological outcomes in dopamine neurons depending on the receptor's locationEmerging approaches for treatment of schizophrenia: modulation of cholinergic signaling.Activation of M1 and M4 muscarinic receptors as potential treatments for Alzheimer's disease and schizophreniaAllosteric Modulation of GPCRs: New Insights and Potential Utility for Treatment of Schizophrenia and Other CNS Disorders.Antipsychotic-like Effects of M4 Positive Allosteric Modulators Are Mediated by CB2 Receptor-Dependent Inhibition of Dopamine ReleaseMuscarinic receptor binding, plasma concentration and inhibition of salivation after oral administration of a novel antimuscarinic agent, solifenacin succinate in mice.Involvement of inward rectifier and M-type currents in carbachol-induced epileptiform synchronizationPhysiological roles of CNS muscarinic receptors gained from knockout mice.Muscarinic M1 receptor and cannabinoid CB1 receptor do not modulate paraoxon-induced seizures.Selectivity of agonists for the active state of M1 to M4 muscarinic receptor subtypes.M(3) muscarinic acetylcholine receptor plays a critical role in parasympathetic control of salivation in mice.Alterations in behavioral responses to a cholinergic agonist in post-pubertal rats with neonatal ventral hippocampal lesions: relationship to changes in muscarinic receptor levels.Chronic lithium chloride administration to unanesthetized rats attenuates brain dopamine D2-like receptor-initiated signaling via arachidonic acid.Pituitary-adrenal responses to oxotremorine and acute stress in male and female M1 muscarinic receptor knockout mice: comparisons to M2 muscarinic receptor knockout mice.Pituitary-adrenal responses to cholinergic stimulation and acute mild stress are differentially elevated in male and female M(2) muscarinic receptor knockout mice.Teaching an Old Drug New Tricks: Agonism, Antagonism, and Biased Signaling of Pilocarpine through M3 Muscarinic Acetylcholine Receptor.
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P2860
Role of specific muscarinic receptor subtypes in cholinergic parasympathomimetic responses, in vivo phosphoinositide hydrolysis, and pilocarpine-induced seizure activity.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
Role of specific muscarinic re ...... pine-induced seizure activity.
@en
Role of specific muscarinic re ...... pine-induced seizure activity.
@nl
type
label
Role of specific muscarinic re ...... pine-induced seizure activity.
@en
Role of specific muscarinic re ...... pine-induced seizure activity.
@nl
prefLabel
Role of specific muscarinic re ...... pine-induced seizure activity.
@en
Role of specific muscarinic re ...... pine-induced seizure activity.
@nl
P2093
P2860
P1476
Role of specific muscarinic re ...... pine-induced seizure activity.
@en
P2093
Christian C Felder
David L McKinzie
Frank P Bymaster
Jesus Gomeza
Jürgen Wess
Masahisa Yamada
Neil M Nathanson
Petra A Carter
Susan E Hamilton
P2860
P304
P356
10.1046/J.1460-9568.2003.02588.X
P407
P577
2003-04-01T00:00:00Z