Model glycosulfopeptides from P-selectin glycoprotein ligand-1 require tyrosine sulfation and a core 2-branched O-glycan to bind to L-selectin.
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Endoglycan, a member of the CD34 family of sialomucins, is a ligand for the vascular selectinsN-glycans of core2 beta(1,6)-N-acetylglucosaminyltransferase-I (C2GnT-I) but not those of alpha(1,3)-fucosyltransferase-VII (FucT-VII) are required for the synthesis of functional P-selectin glycoprotein ligand-1 (PSGL-1): effects on P-, L- and E-sePodocalyxin-like protein is an E-/L-selectin ligand on colon carcinoma cells: comparative biochemical properties of selectin ligands in host and tumor cellsRegulation of PSGL-1 interactions with L-selectin, P-selectin, and E-selectin: role of human fucosyltransferase-IV and -VIIA structure-based sliding-rebinding mechanism for catch bonds.Flow-enhanced adhesion regulated by a selectin interdomain hinge.Heterotropic modulation of selectin affinity by allosteric antibodies affects leukocyte rolling.Evolutionary conservation of P-selectin glycoprotein ligand-1 primary structure and functionThe high affinity selectin glycan ligand C2-O-sLex and mRNA transcripts of the core 2 beta-1,6-N-acetylglucosaminyltransferase (C2GnT1) gene are highly expressed in human colorectal adenocarcinomas.Core 1-derived O-glycans are essential E-selectin ligands on neutrophils.Human L-selectin preferentially binds synthetic glycosulfopeptides modeled after endoglycan and containing tyrosine sulfate residues and sialyl Lewis x in core 2 O-glycansBiomechanics of leukocyte rollingLow force decelerates L-selectin dissociation from P-selectin glycoprotein ligand-1 and endoglycan.A novel fluorescent assay for T-synthase activity.Prominent expression of sialyl Lewis X-capped core 2-branched O-glycans on high endothelial venule-like vessels in gastric MALT lymphomaGlycopeptide analogues of PSGL-1 inhibit P-selectin in vitro and in vivo.Transport features, reaction kinetics and receptor biomechanics controlling selectin and integrin mediated cell adhesion.Tyrosine replacement of PSGL-1 reduces association kinetics with P- and L-selectin on the cell membrane.Human synovial lubricin expresses sialyl Lewis x determinant and has L-selectin ligand activityGlycoforms of human endothelial CD34 that bind L-selectin carry sulfated sialyl Lewis x capped O- and N-glycans.Rolling cell adhesionPSGL-1-dependent myeloid leukocyte activation.Selectin inhibitors: a patent review.Replacing a lectin domain residue in L-selectin enhances binding to P-selectin glycoprotein ligand-1 but not to 6-sulfo-sialyl Lewis xCritical functions of N-glycans in L-selectin-mediated lymphocyte homing and recruitment.Tyrosine sulfation as a protein post-translational modification.Recent progress in the field of neoglycoconjugate chemistry.Targeting P-selectin glycoprotein ligand-1/P-selectin interactions as a novel therapy for metabolic syndrome.Critical but divergent roles for CD62L and CD44 in directing blood monocyte trafficking in vivo during inflammation.Inhibition of P-Selectin and PSGL-1 Using Humanized Monoclonal Antibodies Increases the Sensitivity of Multiple Myeloma Cells to Bortezomib.The novel carbohydrate tumor antigen C2-O-sLe x is upregulated in canine gastric carcinomas.P-selectin glycoprotein ligand-1 decameric repeats regulate selectin-dependent rolling under flow conditions.Core 2 branching beta1,6-N-acetylglucosaminyltransferase and high endothelial venule-restricted sulfotransferase collaboratively control lymphocyte homing.Dimeric galectin-1 binds with high affinity to alpha2,3-sialylated and non-sialylated terminal N-acetyllactosamine units on surface-bound extended glycans.Epitope recognition of antibodies that define the sialomucin, endolyn (CD164), a negative regulator of haematopoiesis.Endothelial L-selectin ligands in sinus mucosa during chronic maxillary rhinosinusitis.Cytoskeletal interactions regulate inducible L-selectin clustering.Rescue of Drosophila Melanogaster l(2)35Aa lethality is only mediated by polypeptide GalNAc-transferase pgant35A, but not by the evolutionary conserved human ortholog GalNAc-transferase-T11.Multivalent interaction and selectivities in selectin binding of functionalized gold colloids decorated with carbohydrate mimetics.
P2860
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P2860
Model glycosulfopeptides from P-selectin glycoprotein ligand-1 require tyrosine sulfation and a core 2-branched O-glycan to bind to L-selectin.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
Model glycosulfopeptides from ...... -glycan to bind to L-selectin.
@en
Model glycosulfopeptides from ...... -glycan to bind to L-selectin.
@nl
type
label
Model glycosulfopeptides from ...... -glycan to bind to L-selectin.
@en
Model glycosulfopeptides from ...... -glycan to bind to L-selectin.
@nl
prefLabel
Model glycosulfopeptides from ...... -glycan to bind to L-selectin.
@en
Model glycosulfopeptides from ...... -glycan to bind to L-selectin.
@nl
P2093
P2860
P356
P1476
Model glycosulfopeptides from ...... -glycan to bind to L-selectin.
@en
P2093
Anne Leppänen
Richard D Cummings
Rodger P McEver
Tadayuki Yago
Vivianne I Otto
P2860
P304
26391-26400
P356
10.1074/JBC.M303551200
P407
P577
2003-05-07T00:00:00Z