Mithramycin induces fetal hemoglobin production in normal and thalassemic human erythroid precursor cells.
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HIF prolyl hydroxylase inhibition results in endogenous erythropoietin induction, erythrocytosis, and modest fetal hemoglobin expression in rhesus macaquesMithramycin forms a stable dimeric complex by chelating with Fe(II): DNA-interacting characteristics, cellular permeation and cytotoxicityConformational changes in DNA upon ligand binding monitored by circular dichroismDocking of molecules identified in bioactive medicinal plants extracts into the p50 NF-kappaB transcription factor: correlation with inhibition of NF-kappaB/DNA interactions and inhibitory effects on IL-8 gene expressionVirtual screening against p50 NF-kappaB transcription factor for the identification of inhibitors of the NF-kappaB-DNA interaction and expression of NF-kappaB upregulated genes.Crystal structure of the [Mg2+-(chromomycin A3)2]-d(TTGGCCAA)2 complex reveals GGCC binding specificity of the drug dimer chelated by a metal ionPLC-beta 1 regulates the expression of miR-210 during mithramycin-mediated erythroid differentiation in K562 cells3-Deazaneplanocin A (DZNep), an inhibitor of S-adenosylmethionine-dependent methyltransferase, promotes erythroid differentiation.Novel GC-rich DNA-binding compound produced by a genetically engineered mutant of the mithramycin producer Streptomyces argillaceus exhibits improved transcriptional repressor activity: implications for cancer therapy.Induction of human fetal hemoglobin via the NRF2 antioxidant response signaling pathwayIncrease of microRNA-210, decrease of raptor gene expression and alteration of mammalian target of rapamycin regulated proteins following mithramycin treatment of human erythroid cells.Generation of new derivatives of the antitumor antibiotic mithramycin by altering the glycosylation pattern through combinatorial biosynthesis.β-Globin-Expressing Definitive Erythroid Progenitor Cells Generated from Embryonic and Induced Pluripotent Stem Cell-Derived Sacs.Comparison of in-vitro and in-vivo response to fetal hemoglobin production and γ-mRNA expression by hydroxyurea in Hemoglobinopathies.Fetal Hemoglobin Inducers from the Natural World: A Novel Approach for Identification of Drugs for the Treatment of {beta}-Thalassemia and Sickle-Cell Anemia.Involvement of miRNA in erythroid differentiation.Alternative options for DNA-based experimental therapy of β-thalassemia.Erythroid induction of K562 cells treated with mithramycin is associated with inhibition of raptor gene transcription and mammalian target of rapamycin complex 1 (mTORC1) functionsRecent trends in the gene therapy of β-thalassemia.Natural Remedies for the Treatment of Beta-Thalassemia and Sickle Cell Anemia-Current Status and Perspectives in Fetal Hemoglobin Reactivation.Peptide nucleic acids targeting β-globin mRNAs selectively inhibit hemoglobin production in murine erythroleukemia cellsSynthesis and antiproliferative activity of quinolone nucleosides against the human myelogenous leukemia k-562 cell line.Piceatannol: a potential futuristic natural stilbene as fetal haemoglobin inducer.Efficient Generation of β-Globin-Expressing Erythroid Cells Using Stromal Cell-Derived Induced Pluripotent Stem Cells from Patients with Sickle Cell Disease.In vitro evaluation of the anti-proliferative activities of the wood essential oils of three Cedrus species against K562 human chronic myelogenous leukaemia cells.Modulation of the biological activity of microRNA-210 with peptide nucleic acids (PNAs).C(5) modified uracil derivatives showing antiproliferative and erythroid differentiation inducing activities on human chronic myelogenous leukemia K562 cells.Elucidation of the DNA-interacting properties and anticancer activity of a Ni(II)-coordinated mithramycin dimer complex.The chromomycin CmmA acetyltransferase: a membrane-bound enzyme as a tool for increasing structural diversity of the antitumour mithramycin.KSHV/HHV-8 infection of human hematopoietic progenitor (CD34+) cells: persistence of infection during hematopoiesis in vitro and in vivo.Rapamycin-mediated induction of gamma-globin mRNA accumulation in human erythroid cells.Mithramycin encapsulated in polymeric micelles by microfluidic technology as novel therapeutic protocol for beta-thalassemia.Generation and Characterization of a Transgenic Mouse Carrying a Functional Human β -Globin Gene with the IVSI-6 Thalassemia Mutation.An Aγ-globin G->A gene polymorphism associated with β039 thalassemia globin gene and high fetal hemoglobin production.Premithramycinone G, an early shunt product of the mithramycin biosynthetic pathway accumulated upon inactivation of oxygenase MtmOIIA combined approach for β-thalassemia based on gene therapy-mediated adult hemoglobin (HbA) production and fetal hemoglobin (HbF) induction.Targeting pre-miRNA by peptide nucleic acids: a new strategy to interfere in the miRNA maturation.Inhibitory Effects of Bangladeshi Medicinal Plant Extracts on Interactions between Transcription Factors and Target DNA Sequences.Entropically-driven binding of mithramycin in the minor groove of C/G-rich DNA sequences.Development and characterization of K562 cell clones expressing BCL11A-XL: Decreased hemoglobin production with fetal hemoglobin inducers and its rescue with mithramycin.
P2860
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P2860
Mithramycin induces fetal hemoglobin production in normal and thalassemic human erythroid precursor cells.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
Mithramycin induces fetal hemo ...... man erythroid precursor cells.
@en
Mithramycin induces fetal hemo ...... man erythroid precursor cells.
@nl
type
label
Mithramycin induces fetal hemo ...... man erythroid precursor cells.
@en
Mithramycin induces fetal hemo ...... man erythroid precursor cells.
@nl
prefLabel
Mithramycin induces fetal hemo ...... man erythroid precursor cells.
@en
Mithramycin induces fetal hemo ...... man erythroid precursor cells.
@nl
P2093
P1433
P1476
Mithramycin induces fetal hemo ...... man erythroid precursor cells.
@en
P2093
Eitan Fibach
Eugenia Prus
Monica Borgatti
Roberto Gambari
P304
P356
10.1182/BLOOD-2002-10-3096
P407
P577
2003-05-08T00:00:00Z