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Design, Synthesis, Crystallographic Studies, and Preliminary Biological Appraisal of New Substituted Triazolo[4,3- b ]pyridazin-8-amine Derivatives as Tankyrase InhibitorsAhR-Mediated, Non-Genomic Modulation of IDO1 FunctionPharmacophore-Based Virtual Screening to Discover New Active Compounds for Human Choline Kinase α1Identification by virtual screening and in vitro testing of human DOPA decarboxylase inhibitorsRat brain guanosine binding site. Biological studies and pseudo-receptor construction.Synthesis, molecular modeling studies, and preliminary pharmacological characterization of all possible 2-(2'-sulfonocyclopropyl)glycine stereoisomers as conformationally constrained L-homocysteic acid analogs.Molecular interaction fields and 3D-QSAR studies of p53-MDM2 inhibitors suggest additional features of ligand-target interaction.Aryl hydrocarbon receptor control of a disease tolerance defence pathwayMetabotropic glutamate receptors: a structural view point.Metabotropic glutamate receptors: structure and new subtype-selective ligands.Targeting glucocorticoid side effects: selective glucocorticoid receptor modulator or glucocorticoid-induced leucine zipper? A perspective.Fitting the complexity of GPCRs modulation into simple hypotheses of ligand design.Exploring the effect of PARP-1 flexibility in docking studies.Scaffold hopping approach on the route to selective tankyrase inhibitors.Very-long-chain fatty acid sphingomyelin in nuclear lipid microdomains of hepatocytes and hepatoma cells: can the exchange from C24:0 to C16:0 affect signal proteins and vitamin D receptor?Distinct roles of immunoreceptor tyrosine-based motifs in immunosuppressive indoleamine 2,3-dioxygenase 1.A Relay Pathway between Arginine and Tryptophan Metabolism Confers Immunosuppressive Properties on Dendritic Cells.Puzzling over MDM4-p53 network.Patented TGR5 modulators: a review (2006 - present).Concepts and Molecular Aspects in the Polypharmacology of PARP-1 Inhibitors.Mechanistic Aspects and Applications of Chiral Ligand-Exchange Chromatography.Immunotherapy… a pursuit race to tomorrow's medicines.Binding properties of different categories of IDO1 inhibitors: a microscale thermophoresis study.The Janus-faced nature of IDO1 in infectious diseases: challenges and therapeutic opportunities.Signal Transducer and Activator of Transcription 1 Plays a Pivotal Role in RET/PTC3 Oncogene-induced Expression of Indoleamine 2,3-Dioxygenase 1.Targeting the MDM2/MDM4 interaction interface as a promising approach for p53 reactivation therapy.Laboratory-Scale Preparative Enantioseparations of Pharmaceutically Relevant Compounds on Commercially Available Chiral Stationary Phases for HPLC.Indoleamine 2,3-dioxygenase 1 (IDO1) is up-regulated in thyroid carcinoma and drives the development of an immunosuppressant tumor microenvironment.Protective effects of Commiphora erythraea resin constituents against cellular oxidative damage.Avicholic Acid: A Lead Compound from Birds on the Route to Potent TGR5 Modulators.Probing the Binding Site of Bile Acids in TGR5.TGR5-mediated bile acid sensing controls glucose homeostasisQuantum mechanics/molecular mechanics (QM/MM) modeling of the irreversible transamination of L-kynurenine to kynurenic acid: the round dance of kynurenine aminotransferase II.Glucocorticoid-induced leucine zipper (GILZ)/NF-kappaB interaction: role of GILZ homo-dimerization and C-terminal domain.Biochemical and molecular characterization of the novel BRAF(V599Ins) mutation detected in a classic papillary thyroid carcinoma.Ligand binding and functional selectivity of L-tryptophan metabolites at the mouse aryl hydrocarbon receptor (mAhR).Poly(ADP-ribose) catabolism triggers AMP-dependent mitochondrial energy failure.Novel polymorphisms of nuclear receptor SHP associated with functional and structural changesChiral ligand-exchange separation and resolution of extremely rigid glutamate analogs: 1-aminospiro[2.2]pentyl-1,4-dicarboxylic acids.Discovery of 6alpha-ethyl-23(S)-methylcholic acid (S-EMCA, INT-777) as a potent and selective agonist for the TGR5 receptor, a novel target for diabesity.
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Antonio Macchiarulo
@ast
Antonio Macchiarulo
@en
Antonio Macchiarulo
@es
Antonio Macchiarulo
@nl
Antonio Macchiarulo
@sl
type
label
Antonio Macchiarulo
@ast
Antonio Macchiarulo
@en
Antonio Macchiarulo
@es
Antonio Macchiarulo
@nl
Antonio Macchiarulo
@sl
prefLabel
Antonio Macchiarulo
@ast
Antonio Macchiarulo
@en
Antonio Macchiarulo
@es
Antonio Macchiarulo
@nl
Antonio Macchiarulo
@sl
P1053
L-2846-2017
P106
P1153
6603748103
P21
P2456
P2798
P31
P3829
P496
0000-0001-9535-4183