Leuprorelin rescues polyglutamine-dependent phenotypes in a transgenic mouse model of spinal and bulbar muscular atrophy.
about
Androgen-modulating agents for spinal bulbar muscular atrophy/Kennedy's diseaseAndrogen-dependent pathology demonstrates myopathic contribution to the Kennedy disease phenotype in a mouse knock-in modelMouse models of polyglutamine diseases in therapeutic approaches: review and data table. Part II.Pathogenic mechanisms and therapeutic strategies in spinobulbar muscular atrophyDeveloping treatment for spinal and bulbar muscular atrophydnc-1/dynactin 1 knockdown disrupts transport of autophagosomes and induces motor neuron degenerationDrosophila as an In Vivo Model for Human Neurodegenerative DiseaseProtein arginine methyltransferase 6 enhances polyglutamine-expanded androgen receptor function and toxicity in spinal and bulbar muscular atrophy.Small ubiquitin-like modifier (SUMO) modification of the androgen receptor attenuates polyglutamine-mediated aggregationPrenatal flutamide enhances survival in a myogenic mouse model of spinal bulbar muscular atrophySpinal and bulbar muscular atrophy: pathogenesis and clinical managementProteome analysis of soluble nuclear proteins reveals that HMGB1/2 suppress genotoxic stress in polyglutamine diseases.Increased mitophagy in the skeletal muscle of spinal and bulbar muscular atrophy patientsDisruption of nongenomic testosterone signaling in a model of spinal and bulbar muscular atrophy.Identification of neuron selective androgen receptor inhibitors.Antiandrogen flutamide protects male mice from androgen-dependent toxicity in three models of spinal bulbar muscular atrophy.The Role of the Heat Shock Protein B8 (HSPB8) in Motoneuron Diseases.Mutant huntingtin impairs Ku70-mediated DNA repair.Animal models of Kennedy disease.Absence of behavioral abnormalities and neurodegeneration in vivo despite widespread neuronal huntingtin inclusions.Pharmacological induction of heat-shock proteins alleviates polyglutamine-mediated motor neuron disease.An interdomain interaction of the androgen receptor is required for its aggregation and toxicity in spinal and bulbar muscular atrophy.Spinal and Bulbar Muscular Atrophy.Pathogenesis and molecular targeted therapy of spinal and bulbar muscular atrophy (SBMA).Insulinlike growth factor (IGF)-1 administration ameliorates disease manifestations in a mouse model of spinal and bulbar muscular atrophyClinical features of spinal and bulbar muscular atrophy.Human adipose-derived mesenchymal stem cells as a new model of spinal and bulbar muscular atrophy.Protein aggregation in motor neurone disorders.Testosterone treatment fails to accelerate disease in a transgenic mouse model of spinal and bulbar muscular atrophyKennedy's disease: pathogenesis and clinical approaches.Post-translational modifications of nuclear receptors and human diseaseThe hnRNP-Htt axis regulates necrotic cell death induced by transcriptional repression through impaired RNA splicing.Current status of treatment of spinal and bulbar muscular atrophy.Transcriptional repression induces a slowly progressive atypical neuronal death associated with changes of YAP isoforms and p73New prospects and strategies for drug target discovery in neurodegenerative disordersThe genetics of neurodegenerative diseases.Convenient diagnosis of spinal and bulbar muscular atrophy using a microchip electrophoresis system.Enhanced aggregation of androgen receptor in induced pluripotent stem cell-derived neurons from spinal and bulbar muscular atrophySex steroid-related candidate genes in psychiatric disorders.Pathogenesis and molecular targeted therapy of spinal and bulbar muscular atrophy.
P2860
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P2860
Leuprorelin rescues polyglutamine-dependent phenotypes in a transgenic mouse model of spinal and bulbar muscular atrophy.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
Leuprorelin rescues polyglutam ...... l and bulbar muscular atrophy.
@en
Leuprorelin rescues polyglutam ...... l and bulbar muscular atrophy.
@nl
type
label
Leuprorelin rescues polyglutam ...... l and bulbar muscular atrophy.
@en
Leuprorelin rescues polyglutam ...... l and bulbar muscular atrophy.
@nl
prefLabel
Leuprorelin rescues polyglutam ...... l and bulbar muscular atrophy.
@en
Leuprorelin rescues polyglutam ...... l and bulbar muscular atrophy.
@nl
P2093
P2860
P356
P1433
P1476
Leuprorelin rescues polyglutam ...... l and bulbar muscular atrophy.
@en
P2093
Akira Inukai
Makoto Minamiyama
Manabu Doyu
Masahisa Katsuno
Yasushi Kobayashi
P2860
P2888
P304
P356
10.1038/NM878
P407
P577
2003-05-18T00:00:00Z
P5875
P6179
1003579949