DNA Damage Induces p53-dependent Down-regulation of hCHK1.
about
Gain of cellular adaptation due to prolonged p53 impairment leads to functional switchover from p53 to p73 during DNA damage in acute myeloid leukemia cellsDown regulation of Chk1 by p53 plays a role in synergistic induction of apoptosis by chemotherapeutics and inhibitors for Jak2 or BCR/ABL in hematopoietic cells.Distinct roles for p53 transactivation and repression in preventing UCN-01-mediated abrogation of DNA damage-induced arrest at S and G2 cell cycle checkpoints.A novel pathological role of p53 in kidney development revealed by gene-environment interactions.p21/CDKN1A mediates negative regulation of transcription by p53.p53-mediated downregulation of Chk1 abrogates the DNA damage-induced G2M checkpoint in K562 cells, resulting in increased apoptosis.
P2860
DNA Damage Induces p53-dependent Down-regulation of hCHK1.
description
2001 nî lūn-bûn
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2001年の論文
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2001年学术文章
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name
DNA Damage Induces p53-dependent Down-regulation of hCHK1.
@en
DNA Damage Induces p53-dependent Down-regulation of hCHK1.
@nl
type
label
DNA Damage Induces p53-dependent Down-regulation of hCHK1.
@en
DNA Damage Induces p53-dependent Down-regulation of hCHK1.
@nl
prefLabel
DNA Damage Induces p53-dependent Down-regulation of hCHK1.
@en
DNA Damage Induces p53-dependent Down-regulation of hCHK1.
@nl
P2093
P2860
P356
P1476
DNA Damage Induces p53-dependent Down-regulation of hCHK1.
@en
P2093
P2860
P304
10641-10645
P356
10.1074/JBC.M007178200
P407
P577
2001-01-04T00:00:00Z