Rational design of alkylene-linked bis-pyridiniumaldoximes as improved acetylcholinesterase reactivators.
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Structure of HI-6*sarin-acetylcholinesterase determined by X-ray crystallography and molecular dynamics simulation: reactivator mechanism and designA conformational change in the peripheral anionic site of Torpedo californica acetylcholinesterase induced by a bis-imidazolium oximeAlterations of serum cholinesterase in patients with gastric cancerEnergetics of Ortho-7 (oxime drug) translocation through the active-site gorge of tabun conjugated acetylcholinesteraseDesign, evaluation and structure-activity relationship studies of the AChE reactivators against organophosphorus pesticides.Kinetic prerequisites of oximes as effective reactivators of organophosphate-inhibited acetylcholinesterase: a theoretical approach.Toxicological considerations of acetylcholinesterase reactivators.Potency of novel oximes to reactivate sarin inhibited human cholinesterases.Russian VX: inhibition and reactivation of acetylcholinesterase compared with VX agent.Reactivation of sarin-inhibited pig brain acetylcholinesterase using oxime antidotesNew series of monoquaternary pyridinium oximes: Synthesis and reactivation potency for paraoxon-inhibited electric eel and recombinant human acetylcholinesterase.Structural bioinformatics and QSAR analysis applied to the acetylcholinesterase and bispyridinium aldoximes.Two step synthesis of a non-symmetric acetylcholinesterase reactivator.Potency of five structurally different acetylcholinesterase reactivators to reactivate human brain cholinesterases inhibited by cyclosarin.Potency of new structurally different oximes to reactivate cyclosarin-inhibited human brain acetylcholinesterases.In vitro evaluation of acetylcholinesterase reactivators as potential antidotes against tabun nerve agent poisonings.The reactivation of tabun-inhibited mutant AChE with Ortho-7: steered molecular dynamics and quantum chemical studies.Synthesis of a novel series of non-symmetrical bispyridinium compounds bearing a xylene linker and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase.
P2860
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P2860
Rational design of alkylene-linked bis-pyridiniumaldoximes as improved acetylcholinesterase reactivators.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
Rational design of alkylene-li ...... ylcholinesterase reactivators.
@en
Rational design of alkylene-li ...... ylcholinesterase reactivators.
@nl
type
label
Rational design of alkylene-li ...... ylcholinesterase reactivators.
@en
Rational design of alkylene-li ...... ylcholinesterase reactivators.
@nl
prefLabel
Rational design of alkylene-li ...... ylcholinesterase reactivators.
@en
Rational design of alkylene-li ...... ylcholinesterase reactivators.
@nl
P2093
P1476
Rational design of alkylene-li ...... ylcholinesterase reactivators.
@en
P2093
Jong-Cheol Lee
Pamela I Hammond
Sharie P Haugabouk
Stephen Brimijoin
Thomas M Kollmeyer
P304
P356
10.1016/S1074-5521(03)00126-1
P577
2003-06-01T00:00:00Z