Differential effects of amino acid substitutions in the beta-sheet floor and alpha-2 helix of HLA-A2 on recognition by alloreactive viral peptide-specific cytotoxic T lymphocytes.

Differential effects of amino acid substitutions in the beta-sheet floor and alpha-2 helix of HLA-A2 on recognition by alloreactive viral peptide-specific cytotoxic T lymphocytes.

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http://www.wikidata.org/entity/Q44516823
HMT, encoded by H-2M3, is a neoclassical major histocompatibility class I antigenHLA-B37 and HLA-A2.1 molecules bind largely nonoverlapping sets of peptidesAlloreactivity studied with mutants of HLA-A2.Alloreactive cytotoxic T lymphocytes recognize epitopes determined by both the alpha helices and beta sheets of the class I peptide binding site.Identification of a crucial energetic footprint on the alpha1 helix of human histocompatibility leukocyte antigen (HLA)-A2 that provides functional interactions for recognition by tax peptide/HLA-A2-specific T cell receptors.Amino acid substitution at peptide-binding pockets of HLA class I molecules increases risk of severe acute GVHD and mortalityExtensive conservation of alpha and beta chains of the human T-cell antigen receptor recognizing HLA-A2 and influenza A matrix peptideThe structure of the antigen-binding groove of major histocompatibility complex class I molecules determines specific selection of self-peptidesPositioning of a peptide in the cleft of HLA-A2 by complementing amino acid changes.Presentation of human minor histocompatibility antigens by HLA-B35 and HLA-B38 molecules.A Micropolymorphism Altering the Residue Triad 97/114/156 Determines the Relative Levels of Tapasin Independence and Distinct Peptide Profiles for HLA-A(*)24 Allotypes.Position 156 influences the peptide repertoire and tapasin dependency of human leukocyte antigen B*44 allotypes.On the nature of peptides involved in T cell alloreactivity.Molecular comparisons of the beta 2-microglobulin-binding site in class I major-histocompatibility-complex alpha-chains and proteins of related sequences
P2860

Differential effects of amino acid substitutions in the beta-sheet floor and alpha-2 helix of HLA-A2 on recognition by alloreactive viral peptide-specific cytotoxic T lymphocytes.

Item
http://www.wikidata.org/entity/Q44516823
description
1989 nî lūn-bûn
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1989年の論文
@ja
1989年学术文章
@wuu
1989年学术文章
@zh
1989年学术文章
@zh-cn
1989年学术文章
@zh-hans
1989年学术文章
@zh-my
1989年学术文章
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1989年學術文章
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1989年學術文章
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name
Differential effects of amino ...... cific cytotoxic T lymphocytes.
@en
Differential effects of amino ...... cific cytotoxic T lymphocytes.
@nl
type
label
Differential effects of amino ...... cific cytotoxic T lymphocytes.
@en
Differential effects of amino ...... cific cytotoxic T lymphocytes.
@nl
prefLabel
Differential effects of amino ...... cific cytotoxic T lymphocytes.
@en
Differential effects of amino ...... cific cytotoxic T lymphocytes.
@nl
P1433
P1476
P2093
P304
P31
P407
P433
P478
P577
P698
P921
P1433
P1476
Differential effects of amino ...... ecific cytotoxic T lymphocytes
@en
P2093
P304
P31
P407
P433
P478
P577
P698
P921