Glucose-induced translational control of proinsulin biosynthesis is proportional to preproinsulin mRNA levels in islet beta-cells but not regulated via a positive feedback of secreted insulin.
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Loss of sugar detection by GLUT2 affects glucose homeostasis in miceNuclear translocation of an ICA512 cytosolic fragment couples granule exocytosis and insulin expression in {beta}-cellsInsulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteomeGLP-1 receptor activated insulin secretion from pancreatic β-cells: mechanism and glucose dependenceSynergy of glucose and growth hormone signalling in islet cells through ICA512 and STAT5Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasisGlucose regulation of insulin gene transcription and pre-mRNA processing in human islets.Expedited approaches to whole cell electron tomography and organelle mark-up in situ in high-pressure frozen pancreatic isletsPancreatic β-Cell Adaptive Plasticity in Obesity Increases Insulin Production but Adversely Affects Secretory Function.Insulin gene expression is regulated by DNA methylationAcute insulin signaling in pancreatic beta-cells is mediated by multiple Raf-1 dependent pathwaysNkx6.1 is essential for maintaining the functional state of pancreatic beta cells.A model of insulin resistance in mice, born to diabetic pregnancy, is associated with alterations of transcription-related genes in pancreas and epididymal adipose tissueEvaluation of the INS-1 832/13 cell line as a beta-cell based screening system to assess pollutant effects on beta-cell function.Islet beta cell failure in type 2 diabetesNovel insulin sensitizer modulates nutrient sensing pathways and maintains β-cell phenotype in human islets.FoxO feedback control of basal IRS-2 expression in pancreatic β-cells is distinct from that in hepatocytesPancreatic islet cell therapy for type I diabetes: understanding the effects of glucose stimulation on islets in order to produce better islets for transplantation.The IRE1α/XBP1s Pathway Is Essential for the Glucose Response and Protection of β Cells.Translational control of glucose-induced islet amyloid polypeptide production in pancreatic isletsIslet autoantigens: structure, function, localization, and regulation.GAD65 autoantibodies and its role as biomarker of Type 1 diabetes and Latent Autoimmune Diabetes in Adults (LADA).Antidiabetic effect and mode of action of cytopiloyneThe unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetesDifferences in insulin biosynthesis pathway between small and large islets do not correspond to insulin secretionDirect autocrine action of insulin on β-cells: does it make physiological sense?Effects of Tocotrienols on Insulin Secretion-Associated Genes Expression of Rat Pancreatic Islets in a Dynamic Culture.Emerging roles for the ubiquitin-proteasome system and autophagy in pancreatic beta-cells.Involvement of Per-Arnt-Sim Kinase and extracellular-regulated kinases-1/2 in palmitate inhibition of insulin gene expression in pancreatic beta-cells.Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells.In vitro differentiation potential of human haematopoietic CD34(+) cells towards pancreatic β-cells.Noncanonical activation of Akt/protein kinase B in {beta}-cells by the incretin hormone glucose-dependent insulinotropic polypeptide.Microassay for glucose-induced preproinsulin mRNA expression to assess islet functional potency for islet transplantation.Reduced expression of the insulin receptor in mouse insulinoma (MIN6) cells reveals multiple roles of insulin signaling in gene expression, proliferation, insulin content, and secretion.Glucose-stimulated protein synthesis in pancreatic beta-cells parallels an increase in the availability of the translational ternary complex (eIF2-GTP.Met-tRNAi) and the dephosphorylation of eIF2 alpha.The dynamic plasticity of insulin production in β-cells.Glucose effects on beta-cell growth and survival require activation of insulin receptors and insulin receptor substrate 2.Mitochondrial oxidative stress contributes differently to rat pancreatic islet cell apoptosis and insulin secretory defects after prolonged culture in a low non-stimulating glucose concentration.Pancreatic islet overproduction of H2S and suppressed insulin release in Zucker diabetic rats.Hedgehog signals inhibit postnatal beta cell neogenesis from adult rat exocrine pancreas in vitro.
P2860
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P2860
Glucose-induced translational control of proinsulin biosynthesis is proportional to preproinsulin mRNA levels in islet beta-cells but not regulated via a positive feedback of secreted insulin.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
Glucose-induced translational ...... feedback of secreted insulin.
@en
Glucose-induced translational ...... feedback of secreted insulin.
@nl
type
label
Glucose-induced translational ...... feedback of secreted insulin.
@en
Glucose-induced translational ...... feedback of secreted insulin.
@nl
prefLabel
Glucose-induced translational ...... feedback of secreted insulin.
@en
Glucose-induced translational ...... feedback of secreted insulin.
@nl
P2093
P2860
P356
P1476
Glucose-induced translational ...... feedback of secreted insulin.
@en
P2093
Barton Wicksteed
Christopher J Rhodes
Cristina Alarcon
Isabelle Briaud
Melissa K Lingohr
P2860
P304
42080-42090
P356
10.1074/JBC.M303509200
P407
P577
2003-08-18T00:00:00Z