The amyloid beta peptide (Abeta(1-40)) is thermodynamically soluble at physiological concentrations.
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Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs)Requirement of aggregation propensity of Alzheimer amyloid peptides for neuronal cell surface binding.Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide.Effect of metals on kinetic pathways of amyloid-β aggregationIntrinsic linear heterogeneity of amyloid β protein fibrils revealed by higher resolution mass-per-length determinations.Stem cell models of Alzheimer's disease: progress and challenges.The 37kDa/67kDa laminin receptor acts as a receptor for Aβ42 internalization.Heterogeneous diffusion of a membrane-bound pHLIP peptide.Cell surface binding and internalization of aβ modulated by degree of aggregationTwo distinct amyloid beta-protein (Abeta) assembly pathways leading to oligomers and fibrils identified by combined fluorescence correlation spectroscopy, morphology, and toxicity analyses.Environmental factors preceding aβ40 monomer to oligomers and the detection of oligomers in Alzheimer's disease patient serumAntiamyloidogenic Activity of Aβ42-Binding Peptoid in Modulating Amyloid Oligomerization.Steric Crowding of the Turn Region Alters the Tertiary Fold of Amyloid-β18-35 and Makes It Soluble.Amyloid-beta aggregation.Polymorph-specific kinetics and thermodynamics of β-amyloid fibril growth.Distinct Membrane Disruption Pathways Are Induced by 40-Residue β-Amyloid Peptides.Plug-based microfluidics with defined surface chemistry to miniaturize and control aggregation of amyloidogenic peptides.Metabolite-initiated protein misfolding may trigger Alzheimer's disease.Bioinorganic chemistry of copper and zinc ions coordinated to amyloid-beta peptide.Oxidative stress and cell membranes in the pathogenesis of Alzheimer's disease.The use of mass spectrometry to study amyloid-β peptides.Glucose directs amyloid-beta into membrane-active oligomers.A kinetic model for beta-amyloid adsorption at the air/solution interface and its implication to the beta-amyloid aggregation process.Aggregation of Beta-Amyloid Peptides Proximal to Zwitterionic Lipid Bilayers.Structure-activity relationships in peptide modulators of β-amyloid protein aggregation: variation in α,α-disubstitution results in altered aggregate size and morphologyDetecting amyloid-beta aggregation with fiber-based fluorescence correlation spectroscopyTwo distinct conformations of Abeta aggregates on the surface of living PC12 cells.Crown ethers attenuate aggregation of amyloid beta of Alzheimer's disease.Anomalous diffusion of proteins due to molecular crowding.Nature of the amyloid-beta monomer and the monomer-oligomer equilibrium.Measurement of the attachment and assembly of small amyloid-β oligomers on live cell membranes at physiological concentrations using single-molecule tools.On the stability of the soluble amyloid aggregates.Reversal of temperature-induced conformational changes in the amyloid-beta peptide, Abeta40, by the beta-sheet breaker peptides 16-23 and 17-24.Two pyridine derivatives as potential Cu(II) and Zn(II) chelators in therapy for Alzheimer's disease.Amyloid-beta protofibrils differ from amyloid-beta aggregates induced in dilute hexafluoroisopropanol in stability and morphology.Protein aggregation probed by two-photon fluorescence correlation spectroscopy of native tryptophan.Single-molecule assays for investigating protein misfolding and aggregation.Development of multifunctional heterocyclic Schiff base as a potential metal chelator: a comprehensive spectroscopic approach towards drug discovery.A peptide probe for detection of various beta-amyloid oligomers.Theory of amyloid fibril nucleation from folded proteins.
P2860
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P2860
The amyloid beta peptide (Abeta(1-40)) is thermodynamically soluble at physiological concentrations.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
The amyloid beta peptide (Abet ...... physiological concentrations.
@en
The amyloid beta peptide
@nl
type
label
The amyloid beta peptide (Abet ...... physiological concentrations.
@en
The amyloid beta peptide
@nl
prefLabel
The amyloid beta peptide (Abet ...... physiological concentrations.
@en
The amyloid beta peptide
@nl
P2093
P356
P1433
P1476
The amyloid beta peptide (Abet ...... physiological concentrations.
@en
P2093
David J E Callaway
Parijat Sengupta
P304
10506-10513
P356
10.1021/BI0341410
P407
P577
2003-09-01T00:00:00Z