A multiscale simulation system for the prediction of drug-induced cardiotoxicity.
about
Top-down, Bottom-up and Middle-out Strategies for Drug Cardiac Safety Assessment via Modeling and SimulationsRecent developments in using mechanistic cardiac modelling for drug safety evaluationInroads to predict in vivo toxicology-an introduction to the eTOX ProjectComputer-based prediction of the drug proarrhythmic effect: problems, issues, known and suspected challengesTowards structural systems pharmacology to study complex diseases and personalized medicineGenetic variants in Alzheimer disease - molecular and brain network approachesThe eTOX data-sharing project to advance in silico drug-induced toxicity predictionEvaluation of an in silico cardiac safety assay: using ion channel screening data to predict QT interval changes in the rabbit ventricular wedge.Model of the distribution of diastolic left ventricular posterior wall thickness in healthy adults and its impact on the behavior of a string of virtual cardiomyocytes.Slow delayed rectifying potassium current (IKs ) - analysis of the in vitro inhibition data and predictive model development.The innovative medicines initiative: a European response to the innovation challenge.The effect of network biology on drug toxicology.Tuning HERG out: antitarget QSAR models for drug developmentReviewing ligand-based rational drug design: the search for an ATP synthase inhibitor.Modelling the Transport of Nanoparticles under Blood Flow using an Agent-based ApproachInter-individual variability in the pre-clinical drug cardiotoxic safety assessment--analysis of the age-cardiomyocytes electric capacitance dependence.Finding the rhythm of sudden cardiac death: new opportunities using induced pluripotent stem cell-derived cardiomyocytesApplication of cardiac electrophysiology simulations to pro-arrhythmic safety testing.Public-private partnerships as driving forces in the quest for innovative medicinesComputational methods of studying the binding of toxins from venomous animals to biological ion channels: theory and applications.Circadian models of serum potassium, sodium, and calcium concentrations in healthy individuals and their application to cardiac electrophysiology simulations at individual levelThe innovative medicines initiative: a public private partnership model to foster drug discovery.In silico assessment of drug safety in human heart applied to late sodium current blockersCombining wet and dry research: experience with model development for cardiac mechano-electric structure-function studies.Multiscale Modeling in the Clinic: Drug Design and DevelopmentQuantitative Evaluation and Prediction of Drug Effects and Toxicological Risk Using Mechanistic Multiscale Models.Toward a unifying strategy for the structure-based prediction of toxicological endpoints.Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment.Flexible composition and execution of high performance, high fidelity multiscale biomedical simulations.Computational Models for Predictive Cardiac Ion Channel Pharmacology.2D- and 3D-QSAR studies of a series of benzopyranes and benzopyrano[3,4b][1,4]-oxazines as inhibitors of the multidrug transporter P-glycoprotein.Early Drug Discovery Prediction of Proarrhythmia Potential and Its CovariatesAdverse outcome pathways: opportunities, limitations and open questionsLegacy data sharing to improve drug safety assessment: the eTOX project.Virtual population generator for human cardiomyocytes parameters: in silico drug cardiotoxicity assessment.Integrative Modeling Strategies for Predicting Drug Toxicities at the eTOX Project.In-silico assessment of the dynamic effects of amiodarone and dronedarone on human atrial patho-electrophysiology.
P2860
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P2860
A multiscale simulation system for the prediction of drug-induced cardiotoxicity.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
@zh-hant
name
A multiscale simulation system for the prediction of drug-induced cardiotoxicity.
@en
A multiscale simulation system for the prediction of drug-induced cardiotoxicity.
@nl
type
label
A multiscale simulation system for the prediction of drug-induced cardiotoxicity.
@en
A multiscale simulation system for the prediction of drug-induced cardiotoxicity.
@nl
prefLabel
A multiscale simulation system for the prediction of drug-induced cardiotoxicity.
@en
A multiscale simulation system for the prediction of drug-induced cardiotoxicity.
@nl
P50
P356
P1476
A multiscale simulation system for the prediction of drug-induced cardiotoxicity.
@en
P2093
Cristian Obiol-Pardo
P304
P356
10.1021/CI100423Z
P577
2011-01-20T00:00:00Z