DNA base damage by the antitumor agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine).
about
Quinoxaline 1,4-di-N-Oxides: Biological Activities and Mechanisms of ActionsInsight into mechanisms of 3'-5' exonuclease activity and removal of bulky 8,5'-cyclopurine adducts by apurinic/apyrimidinic endonucleasesInitiation of DNA strand cleavage by 1,2,4-benzotriazine 1,4-dioxide antitumor agents: mechanistic insight from studies of 3-methyl-1,2,4-benzotriazine 1,4-dioxideThe photochemistry of 8-bromo-2'-deoxyadenosine. A direct entry to cyclopurine lesions.The 8,5'-cyclopurine-2'-deoxynucleosides: candidate neurodegenerative DNA lesions in xeroderma pigmentosum, and unique probes of transcription and nucleotide excision repair.Isotopic labeling experiments that elucidate the mechanism of DNA strand cleavage by the hypoxia-selective antitumor agent 1,2,4-benzotriazine 1,4-di-N-oxideMechanisms of free radical-induced damage to DNA.Toward hypoxia-selective DNA-alkylating agents built by grafting nitrogen mustards onto the bioreductively activated, hypoxia-selective DNA-oxidizing agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine).Significant disparity in base and sugar damage in DNA resulting from neutron and electron irradiationActive transcriptomic and proteomic reprogramming in the C. elegans nucleotide excision repair mutant xpa-1.New functions of XPC in the protection of human skin cells from oxidative damageComplete release of (5'S)-8,5'-cyclo-2'-deoxyadenosine from dinucleotides, oligodeoxynucleotides and DNA, and direct comparison of its levels in cellular DNA with other oxidatively induced DNA lesions.Synthesis, Crystal Structure, and Rotational Energy Profile of 3-Cyclopropyl-1,2,4-benzotriazine 1,4-Di-N-oxide.DNA strand cleaving properties and hypoxia-selective cytotoxicity of 7-chloro-2-thienylcarbonyl-3-trifluoromethylquinoxaline 1,4-dioxide.Electronic structures and spin topologies of gamma-picoliniumyl radicals. A study of the homolysis of N-methyl-gamma-picolinium and of benzo-, dibenzo-, and naphthoannulated analogs.Replication of 2-hydroxyadenine-containing DNA and recognition by human MutSalpha.Accumulation of (5'S)-8,5'-cyclo-2'-deoxyadenosine in organs of Cockayne syndrome complementation group B gene knockout mice.Altered 8-oxoguanine glycosylase in mild cognitive impairment and late-stage Alzheimer's disease brain.An overview of chemical processes that damage cellular DNA: spontaneous hydrolysis, alkylation, and reactions with radicals.Enzymatic conversion of 6-nitroquinoline to the fluorophore 6-aminoquinoline selectively under hypoxic conditions.Purine 5',8-cyclonucleoside lesions: chemistry and biology.Development of novel benzotriazines for drug discovery.Biomarkers of oxidatively induced DNA damage in dreissenid mussels: A genotoxicity assessment tool for the Laurentian Great Lakes.Measurement of oxidatively induced DNA damage and its repair, by mass spectrometric techniques.NIST gold nanoparticle reference materials do not induce oxidative DNA damage.Divergent effects of oxidatively induced modification to the C8 of 2'-deoxyadenosine on transcription factor binding: 8,5'(S)-cyclo-2'-deoxyadenosine inhibits the binding of multiple sequence specific transcription factors, while 8-oxo-2'-deoxyadenoMulti-level Quantum Mechanics and Molecular Mechanics Study of Ring Opening Process of Guanine Damage by Hydroxyl Radical in Aqueous Solution.DNA strand damage product analysis provides evidence that the tumor cell-specific cytotoxin tirapazamine produces hydroxyl radical and acts as a surrogate for O(2).Tandem mass spectrometry-based detection of c4'-oxidized abasic sites at specific positions in DNA fragments.A real-time QCM-D approach to monitoring mammalian DNA damage using DNA adsorbed to a polyelectrolyte surface.Increased oxidative damage in nuclear and mitochondrial DNA in mild cognitive impairment.Characterisation of radicals formed by the triazine 1,4-dioxide hypoxia-activated prodrug, SN30000.Increased oxidative damage in nuclear and mitochondrial DNA in Alzheimer's disease.Application of Suzuki-Miyaura and Buchwald-Hartwig Cross-coupling Reactions to the Preparation of Substituted 1,2,4-Benzotriazine 1-Oxides Related to the Antitumor Agent Tirapazamine.
P2860
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P2860
DNA base damage by the antitumor agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine).
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
DNA base damage by the antitum ...... ne 1,4-dioxide (tirapazamine).
@en
DNA base damage by the antitum ...... ne 1,4-dioxide (tirapazamine).
@nl
type
label
DNA base damage by the antitum ...... ne 1,4-dioxide (tirapazamine).
@en
DNA base damage by the antitum ...... ne 1,4-dioxide (tirapazamine).
@nl
prefLabel
DNA base damage by the antitum ...... ne 1,4-dioxide (tirapazamine).
@en
DNA base damage by the antitum ...... ne 1,4-dioxide (tirapazamine).
@nl
P2093
P356
P1476
DNA base damage by the antitum ...... ne 1,4-dioxide (tirapazamine).
@en
P2093
Goutam Chowdhury
Henry Rodriguez
Kent S Gates
Miral Dizdaroglu
Mustafa Birincioglu
Pawel Jaruga
P304
11607-11615
P356
10.1021/JA0352146
P407
P577
2003-09-01T00:00:00Z