Glycogen synthase kinase-3 plays a crucial role in tau exon 10 splicing and intranuclear distribution of SC35. Implications for Alzheimer's disease.
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GSK-3β: A Bifunctional Role in Cell Death PathwaysThe pathobiology of splicingSRp54 (SFRS11), a regulator for tau exon 10 alternative splicing identified by an expression cloning strategyGlycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeuticsRegulation of the alternative splicing of tau exon 10 by SC35 and Dyrk1AGSK-3: Functional Insights from Cell Biology and Animal Models.Alternative splicing of exon 10 in the tau gene as a target for treatment of tauopathies.Bioactive marine drugs and marine biomaterials for brain diseasesInhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivoQuantitative phosphoproteomics reveals link between Helicobacter pylori infection and RNA splicing modulation in host cells.Vitamin A metabolite, all-trans-retinoic acid, mediates alternative splicing of protein kinase C deltaVIII (PKCdeltaVIII) isoform via splicing factor SC35.Structural genomics analysis of alternative splicing and application to isoform structure modeling.Regulation of alternative splicing by reversible protein phosphorylation.Splicing factor SC35 promotes tau expression through stabilization of its mRNA.GSK-3 in Neurodegenerative Diseases.What Are the bona fide GSK3 Substrates?Truncation and activation of GSK-3β by calpain I: a molecular mechanism links to tau hyperphosphorylation in Alzheimer's disease.Advances in tau-based drug discovery.SC35 promotes splicing of the C5-V6-C6 isoform of CD44 pre-mRNAMicroRNAs and the Regulation of Tau MetabolismThe Akt-SRPK-SR axis constitutes a major pathway in transducing EGF signaling to regulate alternative splicing in the nucleus.Structural determinants for alternative splicing regulation of the MAPT pre-mRNAHIV-1-Tat Protein Inhibits SC35-mediated Tau Exon 10 Inclusion through Up-regulation of DYRK1A Kinase.Tau exon 10 alternative splicing and tauopathiesKnock-out and transgenic mouse models of tauopathies.Alternative splicing and tumor progression.Alternative splicing and disease.Phosphorylation of SRSF1 by SRPK1 regulates alternative splicing of tumor-related Rac1b in colorectal cells.Degrade, move, regroup: signaling control of splicing proteins.Functional implications of glycogen synthase kinase-3-mediated tau phosphorylationAlzheimer disease therapeutics: focus on the disease and not just plaques and tanglesRegulation of alternative splicing of tau exon 10.The Role of Glycogen Synthase Kinase 3 Beta in Neuroinflammation and Pain.C-terminal truncation of GSK-3β enhances its dephosphorylation by PP2A.Stimulation of EphB2 attenuates tau phosphorylation through PI3K/Akt-mediated inactivation of glycogen synthase kinase-3β.Increased dosage of Dyrk1A alters alternative splicing factor (ASF)-regulated alternative splicing of tau in Down syndromeNuclear speckles: molecular organization, biological function and role in disease.Regulation of cell survival mechanisms in Alzheimer's disease by glycogen synthase kinase-3Do astrocytes collaborate with neurons in spreading the "infectious" aβ and Tau drivers of Alzheimer's disease?Phosphoproteomics reveals that glycogen synthase kinase-3 phosphorylates multiple splicing factors and is associated with alternative splicing.
P2860
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P2860
Glycogen synthase kinase-3 plays a crucial role in tau exon 10 splicing and intranuclear distribution of SC35. Implications for Alzheimer's disease.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
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2003年學術文章
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2003年學術文章
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name
Glycogen synthase kinase-3 pla ...... tions for Alzheimer's disease.
@en
Glycogen synthase kinase-3 pla ...... tions for Alzheimer's disease.
@nl
type
label
Glycogen synthase kinase-3 pla ...... tions for Alzheimer's disease.
@en
Glycogen synthase kinase-3 pla ...... tions for Alzheimer's disease.
@nl
prefLabel
Glycogen synthase kinase-3 pla ...... tions for Alzheimer's disease.
@en
Glycogen synthase kinase-3 pla ...... tions for Alzheimer's disease.
@nl
P2093
P2860
P356
P1476
Glycogen synthase kinase-3 pla ...... tions for Alzheimer's disease.
@en
P2093
Ana M Mata
Félix Hernández
Jesús Avila
Ratan Bhat
P2860
P304
P356
10.1074/JBC.M311512200
P407
P577
2003-11-05T00:00:00Z