Inhibition of Th1- and Th2-mediated airway inflammation by the sphingosine 1-phosphate receptor agonist FTY720.
about
FTY720 story. Its discovery and the following accelerated development of sphingosine 1-phosphate receptor agonists as immunomodulators based on reverse pharmacologyThe immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptorsTargeting the molecular and cellular interactions of the bone marrow niche in immunologic diseaseTreatment of allergic asthma: modulation of Th2 cells and their responsesSphingosine-1-phosphate receptor 1 agonism attenuates lung ischemia-reperfusion injury.Targeting sphingosine 1 phosphate receptor type 1 receptors in acute kidney injury.The S1P-analog FTY720 differentially modulates T-cell homing via HEV: T-cell-expressed S1P1 amplifies integrin activation in peripheral lymph nodes but not in Peyer patches.An investigation of the impact of the location and timing of antigen-specific T cell division on airways inflammation.Treatment with a sphingosine analog does not alter the outcome of a persistent virus infection.Clonal Expansion of Allergen-specific CD4+ T Cell in the Lung in the Absence of Lymph NodesOral tolerance in the absence of naturally occurring TregsFTY720 regulates bone marrow egress of eosinophils and modulates late-phase skin reaction in miceModulation of chemokines and allergic airway inflammation by selective local sphingosine-1-phosphate receptor 1 agonism in lungsSphingosine-1-phosphate signaling and the skin.Regulation of mammalian physiology, development, and disease by the sphingosine 1-phosphate and lysophosphatidic acid receptors.Effects of lysophospholipids on tumor microenvironmentRegulation of immunity by lysosphingolipids and their G protein-coupled receptorsAberrant ORM (yeast)-like protein isoform 3 (ORMDL3) expression dysregulates ceramide homeostasis in cells and ceramide exacerbates allergic asthma in miceSphingosine-1-phosphate in allergic responses, asthma and anaphylaxis.T regulatory cells and the control of allergic disease.New drugs targeting Th2 lymphocytes in asthma.Analysis of naïve lung CD4 T cells provides evidence of functional lung to lymph node migrationThe role of sphingosine-1-phosphate and its receptors in asthma.Moving targets: cell migration inhibitors as new anti-inflammatory therapies.Sphingosine-1-phosphate synthesis and functions in mast cells.Activation of the lung S1P(1) receptor reduces allergen-induced plasma leakage in miceSphingolipids in inflammation: pathological implications and potential therapeutic targets.Anti-Inflammatory Effects of Ginsenoside Rg3 via NF-κB Pathway in A549 Cells and Human Asthmatic Lung Tissue.Sphingosine kinase and sphingosine 1-phosphate in asthma.The role of sphingolipids in respiratory disease.Perspectives on immunomodulation early in life.Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.Therapeutic Strategies and Pharmacological Tools Influencing S1P Signaling and Metabolism.Sphingosine 1-Phosphate: A Novel Target for Lung Disorders.Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin.The other T helper cells in asthma pathogenesis.Differential sensitivity to Itk kinase signals for T helper 2 cytokine production and chemokine-mediated migrationSphingosine analogue AAL-R increases TLR7-mediated dendritic cell responses via p38 and type I IFN signaling pathways.A common cortactin gene variation confers differential susceptibility to severe asthmaSphingolipids in the lungs.
P2860
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P2860
Inhibition of Th1- and Th2-mediated airway inflammation by the sphingosine 1-phosphate receptor agonist FTY720.
description
2003 nî lūn-bûn
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2003年の論文
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2003年学术文章
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2003年学术文章
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2003年学术文章
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@zh-hans
2003年学术文章
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2003年学术文章
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2003年學術文章
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2003年學術文章
@zh-hant
name
Inhibition of Th1- and Th2-med ...... phate receptor agonist FTY720.
@en
Inhibition of Th1- and Th2-med ...... phate receptor agonist FTY720.
@nl
type
label
Inhibition of Th1- and Th2-med ...... phate receptor agonist FTY720.
@en
Inhibition of Th1- and Th2-med ...... phate receptor agonist FTY720.
@nl
prefLabel
Inhibition of Th1- and Th2-med ...... phate receptor agonist FTY720.
@en
Inhibition of Th1- and Th2-med ...... phate receptor agonist FTY720.
@nl
P2093
P1476
Inhibition of Th1- and Th2-med ...... phate receptor agonist FTY720.
@en
P2093
Alexandre Trifilieff
Christoph Walker
Claudia Zuany-Amorim
Corinne Manlius
David M Kemeny
Elzbieta Sawicka
Volker Brinkmann
P304
P356
10.4049/JIMMUNOL.171.11.6206
P407
P577
2003-12-01T00:00:00Z