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Functional Selectivity and Antidepressant Activity of Serotonin 1A Receptor LigandsA linear combination of pharmacophore hypotheses as a new tool in search of new active compounds--an application for 5-HT1A receptor ligandsThe Comparison of MTT and CVS Assays for the Assessment of Anticancer Agent InteractionsMolecular structure of some 3-amino-2-oxazolidinone derivatives.New validated HPLC methodology for the determination of (-)-trans-paroxetine and its enantiomer in pharmaceutical formulations with use of ovomucoid chiral stationary phase.Mass-spectrometric studies of new 6-nitroquipazines-serotonin transporter inhibitorsMolecular mechanism of serotonin transporter inhibition elucidated by a new flexible docking protocol.Synthesis, in vitro binding studies and docking of long-chain arylpiperazine nitroquipazine analogues, as potential serotonin transporter inhibitors.Proapoptotic effects of novel pentabromobenzylisothioureas in human leukemia cell lines.Conformational flexibility of serotonin1A receptor ligands from crystallographic data. Updated model of the receptor pharmacophore.Synthesis, antidepressant evaluation and docking studies of long-chain alkylnitroquipazines as serotonin transporter inhibitors.Identification of novel serotonin transporter compounds by virtual screening.From Homology Models to a Set of Predictive Binding Pockets-a 5-HT1A Receptor Case Study.Ligand-directed trafficking of receptor stimulus.Up-regulation of glutathione-related genes, enzyme activities and transport proteins in human cervical cancer cells treated with doxorubicin.New benzimidazole-derived isothioureas as potential antileukemic agents--studies in vitro.Proapoptotic activity of heterocyclic compounds containing succinimide moiety in the promyelocytic leukemia cell line HL-60.Serotonin transporter and receptor ligands with antidepressant activity as neuroprotective and proapoptotic agents.Proapoptotic effects of new pentabromobenzylisothiouronium salts in a human prostate adenocarcinoma cell line.Synthesis and proapoptotic properties of new casein kinase II inhibitors.Genotoxicity of alpha-asarone analogues.Models of 5-hydroxytryptamine receptors. A review.The development and validation of a novel virtual screening cascade protocol to identify potential serotonin 5-HT(7)R antagonists.Molecular dynamics of 5-HT1A and 5-HT2A serotonin receptors with methylated buspirone analogues.Interaction of 1,2,4-substituted piperazines, new serotonin receptor ligands, with 5-HT1A and 5-HT2A receptors.Pharmacological properties and SAR of new 1,4-disubstituted piperazine derivatives with hypnotic-sedative activity.Rigid analogues of buspirone and gepirone, 5-HT1A receptors partial agonists.Intrinsic activity and comparative molecular dynamics of buspirone analogues at the 5-HT(1A) receptors.The molecular interactions of buspirone analogues with the serotonin transporter.Structure-retention relationship in a series of chiral 1,4-disubstituted piperazine derivatives on carbohydrate chiral stationary phases.3D QSAR study of hypolipidemic asarones by comparative molecular surface analysis.Deoxynucleosides with benzimidazoles as aglycone moiety are potent anticancer agents.Autophagic cell death and premature senescence: New mechanism of 5-fluorouracil and sulforaphane synergistic anticancer effect in MDA-MB-231 triple negative breast cancer cell line.New enantiomeric fluorine-containing derivatives of sulforaphane: synthesis, absolute configurations and biological activity.Sulforaphane Regulates NFE2L2/Nrf2-Dependent Xenobiotic Metabolism Phase II and Phase III Enzymes Differently in Human Colorectal Cancer and Untransformed Epithelial Colon Cells.Organofluorine Isoselenocyanate Analogues of Sulforaphane: Synthesis and Anticancer Activity.The ligand-binding site of buspirone analogues at the 5-HT1A receptor.13C cross-polarization magic angle spinning NMR and gauge-independent atomic orbital, coupled Hartree-Fock calculations of buspirone analogues. Part 2. Hydrochlorides and perchlorates of 1-arylpiperazine-4-alkylimidesBuspirone Analogs as Ligands of the 5-HT1A Receptor. 1. The Molecular Structure of Buspirone and Its Two AnalogsSome analogues of 1,4-disubstituted piperazines as hypnotic and sedative agents
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P50
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Pools onderzoeker
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Zdzisław Chilmonczyk
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Zdzisław Chilmonczyk
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