Residue Asp-189 controls both substrate binding and the monovalent cation specificity of thrombin.
about
Structural basis of Na+ activation mimicry in murine thrombinEngineering Protein Allostery: 1.05 Å Resolution Structure and Enzymatic Properties of a Na+-activated TrypsinMutant N143P Reveals How Na+ Activates ThrombinRigidification of the autolysis loop enhances Na+ binding to thrombinAutoactivation of Thrombin PrecursorsLoop Electrostatics Asymmetry Modulates the Preexisting Conformational Equilibrium in ThrombinStructure-based predictive models for allosteric hot spots.Engineering thrombin for selective specificity toward protein C and PAR1.Redesigning allosteric activation in an enzyme.Why Ser and not Thr brokers catalysis in the trypsin foldDeterminants of specificity in coagulation proteases.Expression of allosteric linkage between the sodium ion binding site and exosite I of thrombin during prothrombin activation.Role of Na+ and K+ in enzyme function.Factor Va alters the conformation of the Na+-binding loop of factor Xa in the prothrombinase complexThrombin.A propeptide-independent protease from Tannerella sp.6_1_58FAA_CT1 displays trypsin-like specificity.Crystal structure of wild-type human thrombin in the Na+-free state.Comparative binding energy analysis for binding affinity and target selectivity prediction.Thrombin functions through its RGD sequence in a non-canonical conformation.Molecular dissection of Na+ binding to thrombin.Murine thrombin lacks Na+ activation but retains high catalytic activity.
P2860
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P2860
Residue Asp-189 controls both substrate binding and the monovalent cation specificity of thrombin.
description
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name
Residue Asp-189 controls both ...... ation specificity of thrombin.
@en
Residue Asp-189 controls both ...... ation specificity of thrombin.
@nl
type
label
Residue Asp-189 controls both ...... ation specificity of thrombin.
@en
Residue Asp-189 controls both ...... ation specificity of thrombin.
@nl
prefLabel
Residue Asp-189 controls both ...... ation specificity of thrombin.
@en
Residue Asp-189 controls both ...... ation specificity of thrombin.
@nl
P2093
P2860
P356
P1476
Residue Asp-189 controls both ...... ation specificity of thrombin.
@en
P2093
Angelene M Cantwell
Enrico Di Cera
Leslie A Bush
Peter Shih
Swati Prasad
P2860
P304
10103-10108
P356
10.1074/JBC.M312614200
P407
P577
2003-12-16T00:00:00Z