The absence of p53 is critical for the induction of apoptosis by 5-aza-2'-deoxycytidine.
about
Targeting epigenetic pathways in acute myeloid leukemia and myelodysplastic syndrome: a systematic review of hypomethylating agents trialsA new class of quinoline-based DNA hypomethylating agents reactivates tumor suppressor genes by blocking DNA methyltransferase 1 activity and inducing its degradation.Tumor heterogeneity: mechanisms and bases for a reliable application of molecular marker designp53 cooperates with DNA methylation and a suicidal interferon response to maintain epigenetic silencing of repeats and noncoding RNAsAlteration of the DNA methylation status of donor cells impairs the developmental competence of porcine cloned embryosDecreased expression of connective tissue growth factor in non-small cell lung cancer is associated with clinicopathological variables and can be restored by epigenetic modifiers.The epigenetics of adult (somatic) stem cells.Potential of DNMT and its Epigenetic Regulation for Lung Cancer Therapy.Identification of Predictive DNA Methylation Biomarkers for Chemotherapy Response in Colorectal Cancer.The p53 protein plays a central role in the mechanism of action of epigentic drugs that alter the methylation of cytosine residues in DNA.Epigenetic mechanisms in senescence, immortalisation and cancer.The cardiac glycoside convallatoxin inhibits the growth of colorectal cancer cells in a p53-independent manner.5-aza-2',2'-Difluroro Deoxycytidine (NUC013): A Novel Nucleoside DNA Methyl Transferase Inhibitor and Ribonucleotide Reductase Inhibitor for the Treatment of CancerDNA hypomethylation upregulates expression of the MGAT3 gene in HepG2 cells and leads to changes in N-glycosylation of secreted glycoproteins.The Role of the p53 Protein in Stem-Cell Biology and Epigenetic Regulation.Selected drugs that inhibit DNA methylation can preferentially kill p53 deficient cells.Decitabine induces delayed reactive oxygen species (ROS) accumulation in leukemia cells and induces the expression of ROS generating enzymes.SGI-110 and entinostat therapy reduces lung tumor burden and reprograms the epigenome.Combined treatment with low concentrations of decitabine and SAHA causes cell death in leukemic cell lines but not in normal peripheral blood lymphocytesThe DNA methyltransferase inhibitors zebularine and decitabine induce mitochondria-mediated apoptosis and DNA damage in p53 mutant leukemic T cells.DNA methylation inhibitor 5-Aza-2'-deoxycytidine induces reversible genome-wide DNA damage that is distinctly influenced by DNA methyltransferases 1 and 3B.Synergic antiproliferative effect of DNA methyltransferase inhibitor in combination with anticancer drugs in gastric carcinoma.5-Aza-2'-deoxycytidine induces p21WAF expression by demethylation of p73 leading to p53-independent apoptosis in myeloid leukemia.p53 and DNA methylation suppress the TRAIN to cell death.The interplay between epigenetic changes and the p53 protein in stem cells.P53 at the start of the 21st century: lessons from elephants.Putting p53 in Context.
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P2860
The absence of p53 is critical for the induction of apoptosis by 5-aza-2'-deoxycytidine.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh
2004年學術文章
@zh-hant
name
The absence of p53 is critical for the induction of apoptosis by 5-aza-2'-deoxycytidine.
@en
The absence of p53 is critical for the induction of apoptosis by 5-aza-2'-deoxycytidine.
@nl
type
label
The absence of p53 is critical for the induction of apoptosis by 5-aza-2'-deoxycytidine.
@en
The absence of p53 is critical for the induction of apoptosis by 5-aza-2'-deoxycytidine.
@nl
prefLabel
The absence of p53 is critical for the induction of apoptosis by 5-aza-2'-deoxycytidine.
@en
The absence of p53 is critical for the induction of apoptosis by 5-aza-2'-deoxycytidine.
@nl
P2093
P2860
P356
P1433
P1476
The absence of p53 is critical for the induction of apoptosis by 5-aza-2'-deoxycytidine.
@en
P2093
Enrique Samper
Gonzalo González de Buitrago
Mario F Fraga
María Nieto
P2860
P2888
P304
P356
10.1038/SJ.ONC.1207175
P407
P577
2004-01-01T00:00:00Z